Protein Alignment CG7156 and C8orf44-SGK3

DIOPT Version :10

• Sequence 1: NP_650697.1
• Gene: CG7156 / 42187
• FlyBaseID: FBgn0038588
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_001191102.1
• Gene: C8orf44-SGK3 / 100533105
• HGNCID: 48354
• Length: 496
• Species: Homo sapiens
• Alignment Length: 684
• Identity: 119/684 - (17%)
• Similarity: 211/684 - (30%)
• Gaps: 286/684 - (41%)

  Fly    11 SFTVTDTQEH---KGGYTIYKITSIVFPRSVPQALTCLVVWKRFHDVKRLHRELSRRHKSLQLPG 72
            |.::..:.||   |..:|:||:.       |....:...|::|:.:..:|:..|.::..::
Human    15 SVSIPSSDEHREKKKRFTVYKVL-------VSVGRSEWFVFRRYAEFDKLYNTLKKQFPAM---- 68

  Fly    73 KLPVPTDSTYFKRFDAAVIQRRKEYILQLLDFAAQHPALYKCSTFTQFFQ-ETPSPNGSPLKKLY 136
            .|.:|....:...||...|::|:..:.:.:....::|.||.......|.| ::|.....|.:...
Human    69 ALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSEDED 133

  Fly   137 VERSLRLQTEDNGCGSGGSETGTCAGAIADICDKLDLPYDPHDAGGITPLDPRCDKEQTNNESQA 201
            ...|.:|.:.......|.|.                   :||                      |
Human   134 ERSSQKLHSTSQNINLGPSG-------------------NPH----------------------A 157

  Fly   202 KETEIELETKQEPKTDVALTKRDYLRLLTPMASIESDDSDYIYEAALEFSHAVQAEVNLEYAEAH 266
            |.|:.                 |:|::
Human   158 KPTDF-----------------DFLKV-------------------------------------- 167

  Fly   267 ERYKHGVDLLLNGAKQDSSEERRFIAKAKIAKYLARAEEIHANFLANDCPTKKLQFQLSLDTTDG 331
                                    |.|....|.|....::...|.|    .|.||.::.|:..:
Human   168 ------------------------IGKGSFGKVLLAKRKLDGKFYA----VKVLQKKIVLNRKE- 203

  Fly   332 GSVSHLECPWNQLARYKVLQILQDRVMQVQCVTKSQQPAAIMKGVEKPASHSLTQSIFLPQQVPY 396
                                  |..:|..:.|        ::|.|:.                |:
Human   204 ----------------------QKHIMAERNV--------LLKNVKH----------------PF 222

  Fly   397 MVQLLAYFQSEQKIFLLLRQAEGGMLYDYLQSYTPTSSKSVNYGELFPSDQEPEEKEAEEPPLTS 461
            :|.|...||:.:|::.:|....||.|:.:||
Human   223 LVGLHYSFQTTEKLYFVLDFVNGGELFFHLQ---------------------------------- 253

  Fly   462 DSDVSDLVRSSQQLLKSVTNTLSNLQAGVVTPKRNKKVDQNRIRSKPIPEQCLRQWACELAIAIH 526
                                                       |.:..||...|.:|.|:|.|:.
Human   254 -------------------------------------------RERSFPEHRARFYAAEIASALG 275

  Fly   527 SLHGKGVILRDLHMGNILLGAKGQLLLTYFYQNEGLTSDDNYVHKALNLEAVANHFVAPE----R 587
            .||...::.|||...||||.:.|.::||.|    ||..:...:............::|||    :
Human   276 YLHSIKIVYRDLKPENILLDSVGHVVLTDF----GLCKEGIAISDTTTTFCGTPEYLAPEVIRKQ 336

  Fly   588 PLTFRSDWWSYGVVLYQLLLGVPYKVTHP----GQLDLYGCVQYPSESLE--ISDHAKDLLEQLL 646
            |.....|||..|.|||::|.|:|     |    ...::|..:.:...||.  :|..|..:||:||
Human   337 PYDNTVDWWCLGAVLYEMLYGLP-----PFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELL 396

  Fly   647 QLSPELRL----DYDQLQAHPFFKGIDWQAVLEQ 676
            :...:.||    |:.::|.||||:.:.|..::::
Human   397 EKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQK 430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7156	NP_650697.1	PX_SNX15_like	8..124	CDD:132791	23/116 (20%)
		MIT_SNX15	241..315	CDD:239140	6/73 (8%)
		Protein Kinases, catalytic domain	343..665	CDD:473864	70/335 (21%)
C8orf44-SGK3	NP_001191102.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		1/5 (20%)
		PX_CISK	12..120	CDD:132780	23/115 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..156		6/53 (11%)
		STKc_SGK3	165..490	CDD:270755	84/465 (18%)
		Nuclear localization signal. /evidence=ECO:0000250	195..205		1/32 (3%)