DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Non3 and RPF2

DIOPT Version :9

Sequence 1:	NP_650694.2	Gene:	Non3 / 42183	FlyBaseID:	FBgn0038585	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_115570.1	Gene:	RPF2 / 84154	HGNCID:	20870	Length:	306	Species:	Homo sapiens

Alignment Length:	303	Identity:	142/303 - (46%)
Similarity:	202/303 - (66%)	Gaps:	2/303 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SLLRIRKPKTRKGKKVLLAREPQLIESARTMLFLDGRKCGGNVKLCMKDLQALKKPLVKVLNRKN 66
            :|.|:.||||::.|:.|..|||:|.|:.:..:.:.|......|...:||:.|||||...:..:||
Human     3 TLDRVVKPKTKRAKRFLEKREPKLNENIKNAMLIKGGNANATVTKVLKDVYALKKPYGVLYKKKN 67

  Fly    67 DITPFDDPSSLEFLTMKNDAALFTFGSTSKKRPDNIILGRIFENEVLDMFELGIKRYQAISEFKN 131
            ...||:|.:||||.:.|:|.:||.|||.:||||:|:::||:::..||||.||||:.:.::.:.||
Human    68 ITRPFEDQTSLEFFSKKSDCSLFMFGSHNKKRPNNLVIGRMYDYHVLDMIELGIENFVSLKDIKN 132

  Fly   132 EKIGACVKPCLVFNGPKWAQTEELRRLRNLFIDTFQREKVDSIRLQGIEHVLSFTVTDDMNILMR 196
            .|.....||.|:|.|..:..||:.|||::|.||.|:...|.:|||.|:|:||.||..:. .|..|
Human   133 SKCPEGTKPMLIFAGDDFDVTEDYRRLKSLLIDFFRGPTVSNIRLAGLEYVLHFTALNG-KIYFR 196

  Fly   197 SYRILLKKSGQRTPRIELEEIGPSADFSIRRTKIASEDLYKQARKQPKQLKVGKKKNISTDALGN 261
            ||::||||||.|||||||||:|||.|..:|||.:||:||||.:.|.||.||..||||||.|..|.
Human   197 SYKLLLKKSGCRTPRIELEEMGPSLDLVLRRTHLASDDLYKLSMKMPKALKPKKKKNISHDTFGT 261

  Fly   262 TKGRVHLGKQQTGSIQTRRVKALRKTPEEK-KENRQRKKVALK 303
            |.||:|:.||....:|||::|.|:|.|.|: .|:.::|...:|
Human   262 TYGRIHMQKQDLSKLQTRKMKGLKKRPAERITEDHEKKSKRIK 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Non3	NP_650694.2	Brix	3..290	CDD:412658	138/286 (48%)
RPF2	NP_115570.1	Brix	6..297	CDD:321259	139/291 (48%)
RPF2	NP_115570.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	270..306		13/35 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147895
Domainoid	1	1.000	178	1.000	Domainoid score	I3595
eggNOG	1	0.900	-	-		E1_COG5106
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6404
Inparanoid	1	1.050	276	1.000	Inparanoid score	I2970
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53948
OrthoDB	1	1.010	-	-		D434863at33208
OrthoFinder	1	1.000	-	-		FOG0005406
OrthoInspector	1	1.000	-	-		oto91806
orthoMCL	1	0.900	-	-		OOG6_102220
Panther	1	1.100	-	-	LDO	PTHR12728
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1197
SonicParanoid	1	1.000	-	-		X3835
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800