DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osa and arid5b

DIOPT Version :9

Sequence 1:	NP_001163639.1	Gene:	osa / 42130	FlyBaseID:	FBgn0261885	Length:	2716	Species:	Drosophila melanogaster
Sequence 2:	XP_017214107.1	Gene:	arid5b / 100536827	ZFINID:	ZDB-GENE-121214-272	Length:	1079	Species:	Danio rerio

Alignment Length:	967	Identity:	192/967 - (19%)
Similarity:	294/967 - (30%)	Gaps:	305/967 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   971 VPVPQEPFRSTITTTKKSDSLCKLYEMDDNP----------DRRGWLDKLRAFMEERRTPITACP 1025
            |..|:.|          |...||..:.::.|          |.:.:|..|..:|:||:|||...|
Zfish   218 VSKPRNP----------STGSCKRVQSENKPKGDGGDECRTDEQAFLVALYKYMKERKTPIERIP 272

  Fly  1026 TISKQPLDLYRLYIYVKERGGFVEVTKSKTWKDIAGLLGIG-ASSSAAYTLRKHYTKNLLTFECH 1089
            .:..:.::|:.::...::.||:..:|..:.||::...||.. .|:|||...|:||.:.:|.:| .
Zfish   273 YLGFKQINLWTMFQAAQKLGGYEVITARRQWKNVYDELGGNPGSTSAATCTRRHYERLILPYE-R 336

  Fly  1090 FDRGDID-PLPII--QQVEAGSKKKTAKAASVP---------SPGGGH------LDAGTTNSTGS 1136
            |.:|:.| |||..  ::.|...::...||..:|         :|.|..      |:.|..:....
Zfish   337 FTKGEEDKPLPPAKPRKQEGSVQESIIKAKMMPIKRPKDEQKTPRGDKDASAKVLELGMEDMEEL 401

  Fly  1137 SNSQDS--FPAPPGSAPNAAIDGYPGYPGGSPYPVASGPQPDYATAGQMQRPPSQNNPQTPHPGA 1199
            ...|:|  ..||.                                  |..|.|  |:|.|.....
Zfish   402 QEKQNSQQLQAPT----------------------------------QTDRDP--NSPLTEDDEG 430

  Fly  1200 AAAVAAGDNISVSNPFEDPIAAGGG--PGSGTGPGPGQGPGPGAASGGAGAVGAVGGGPQPHPPP 1262
            ...:...|...:.|.:|.   |.||  |..     |..|....:....|..|.||   |..|..|
Zfish   431 VLVIKDEDQPVLHNAYEH---ANGGLLPSL-----PQDGAQLKSEDCDAFPVAAV---PLHHGHP 484

  Fly  1263 PHSPHTAAQQAAGQHQQQHPQHQHPGLPGPPPP------QQQQGQQGQQPPPSVGGGPPPAPQQH 1321
            ..:.||:            .|.:|..|....||      :|.:.::||.....|    .|..||.
Zfish   485 LPNSHTS------------DQWKHGILEYKVPPSALANVEQSRPKEGQNQVVMV----LPTLQQK 533

  Fly  1322 GPGQVPPSPQQHVRPAAGAP---------YPPGGSGYPTPVSRTPGSPYPSQPGAYGQYGSSDQY 1377
             |...|..|.:.|.|.....         ||.|..|..:|:::.......|..|....|
Zfish   534 -PVTSPEIPPERVEPLKKEESCFNFNPLLYPRGNPGIMSPLAKKKMLSQVSGTGLLNNY------ 591

  Fly  1378 NATGPPGQPFGQGPGQYPPQNRNMYPPYGPEGEAPPTGANQYG-------------------PYG 1423
             ..|||           ||.........|.|..:....::|..                   .:.
Zfish   592 -PYGPP-----------PPLVSRRLSSSGTEVSSAGQSSSQVSSSVETSIVIKRPSVIQHAQSFK 644

  Fly  1424 SRPYSQPPPGGPQPPTQTVAGGPPAGGAPGAPPSSAYPTGRPSQQDYYQPPPD-----QSPQPRR 1483
            ||        |.:....:..|....|.:.|.|...:....|........|...     :.|:|.:
Zfish   645 SR--------GSEDRRSSTEGSQKDGCSEGEPVHHSQTLIREPYLKRVDPHSSMEKSAEMPRPGQ 701

  Fly  1484 HPDFIKD--SQPYPGYNARPQIYGAWQSGTQQYRPQ------------YPSSPAPQNWG------ 1528
            .|.|:.:  |.|:.....|...:...:....:|..:            :|.|..|.|.|
Zfish   702 APSFLSEFYSSPHLHNLCRQTEHHLSKEQISKYLSRDVYTRDSETAQGFPPSQHPDNVGLNFSAR 766

  Fly  1529 ------GAPP-RGAAPPP---------------------GAPHGPPIQQ--------PAGVAQWD 1557
                  |.|| |.....|                     |.||. .|||        .||.:|..
Zfish   767 LSQKEKGPPPERVTEEQPTDLSLPKSSPLKLPLSTSTLGGIPHA-AIQQDIKNSPHFQAGNSQSS 830

  Fly  1558 QHRYPPQQGPPPP--------------------PQQQQQPQ-----QQQQQPPYQQVAGPPG--- 1594
            ...|.|:....||                    |..:.:..     .:..:|.....:.|..
Zfish   831 SVDYHPRACRVPPMTVSASKKVTESHSKVLEKTPNSRGEESMGFKIDEMSRPILSTKSSPQNICT 895

  Fly  1595 QQPPQAPPQWAQMNPGQTAQSGIAP---------PGSPLRPPSGPGQQNRMPGMPAQQQQSQQQG 1650
            .:|.:...:..:..|.:.....:.|         ||.|..|.:  ..::..|..||....|....
Zfish   896 ARPLKRNIEDLENGPTEKKIRAVTPLHCSTQRDLPGKPRTPEA--DSESVKPAEPAVHINSYTSE 958

  Fly  1651 GVPQPPPQQASHGGVPSPGLPQV-----GPGGMVKPPYAMPPPPSQGVGQQVGQGPPGGMMSQKP 1710
            |...|.......|..|...:.||     ..|..|.|.|:   .|.|.:..|       .::|
Zfish   959 GHKIPLHSHLFQGLYPGTFVSQVQDMCESLGSHVTPSYS---HPLQYLKNQ-------AVLS--- 1010

  Fly  1711 PPMPGQAMQQQPLQQQ----PPSHQHP-----------HPHQHPQ---HQHPHQMPP 1749
            |.||..|:....:|:|    .|:|.:.           ||..:|.   |..|...||
Zfish  1011 PLMPPFAIHSLMMQRQFLAANPAHMYRHQVGTSYGDILHPGLYPMSALHPQPAFSPP 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osa	NP_001163639.1	BRIGHT	1001..1092	CDD:128777	29/101 (29%)
osa	NP_001163639.1	DUF3518	2191..2451	CDD:288854
arid5b	XP_017214107.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940