Protein Alignment Keap1 and Klhl30

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_081827.1
• Gene: Klhl30 / 70788
• MGIID: 1918038
• Length: 581
• Species: Mus musculus
• Alignment Length: 587
• Identity: 164/587 - (27%)
• Similarity: 265/587 - (45%)
• Gaps: 49/587 - (8%)

  Fly    63 DDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESE 127
            ||:.|.:.::|::.|:.:..:||...|.||.|.|..:..|.|:.:|:..||||.|||.|...||.
Mouse     6 DDLDFHLPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFTESF 70

  Fly   128 MSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNA 192
            ::||:|:.|.|..:.:::.|:|||::.:|:..|..|..:|:....|.|...|..:|::|||.||.
Mouse    71 LARVELRDVEPAMVGQLVDFVYTGRLTITQANVEALTRSASRLNFPTVQKVCGRYLQQQLDATNC 135

  Fly   193 IGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAV 257
            :||..|.||.|.:.:..||..|:..||..|.||:|||||:..:|...:..|.|.||.|:....|:
Mouse   136 LGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLARDRLATCLASDLLQVQPEQSRLEAL 200

  Fly   258 LKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCP 322
            |:||::|..:|...:..:|..|....:....:::.:....::::..||:|.|::...:    :.|
Mouse   201 LRWVRHDPQDRAAHLPELLSLVHLDAVPRPCVQQLLATEPLIQESEACQEALSQGHSE----ELP 261

  Fly   323 GVKERTPNTTRMIFVAGGFF-----------RHSLDILEAYNVDDMTWTTLANLRIP---RSGLG 373
            |:.::   ...::.|.||..           .|.......||.....|..|.:  .|   :.|..
Mouse   262 GLPQK---MQEVLVVVGGRALEEDEDGGEEPSHHTGNFAFYNTKARQWMALPD--FPDYHKWGFS 321

  Fly   374 AAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGS 438
            .|.|....|..||.......::.:.....:......|:|.|||...|.......::..:||:||:
Mouse   322 LAALNSDVYVTGGSRGTKTDTWSTTQAWCFPLKEAIWKPVAPMLKARTNHASTALNGEIYAIGGT 386

  Fly   439 A--GMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPEN 501
            |  .:|    ||.|||..|.|..|.|................||.:|.......:.:::||.|..
Mouse   387 ALDAVE----VERYDPYTDSWAPVGPAPKYVSNFSAAGCQGRLYLVGSSACKYNMLALQCYSPVT 447

  Fly   502 NEWSFL--PPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSAL 564
            :.||.:  |.|....|....||:|..:|::|  |.|::   |..||...:.|..|..........
Mouse   448 DAWSVIASPFLPKYLSSPRCAALNGALYLIG--DNTKK---VYVYDPGANLWQKVQSQHSLHENG 507

  Fly   565 SLTPLDEKLYAIG----GFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVIYQPACSTTF 625
            :|.||.:.||..|    |.||:..:. :|.||...:.|        .|.|....:......||.|
Mouse   508 ALVPLGDLLYVTGGRWQGMDGDYHVE-MEAYDTVRDAW--------ARHGSLPRLWLYHGASTIF 563

  Fly   626 MD 627
            :|
Mouse   564 LD 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	148/528 (28%)
		KELCH repeat	369..416	CDD:276965	9/46 (20%)
		KELCH repeat	420..463	CDD:276965	15/44 (34%)
		KELCH repeat	467..510	CDD:276965	9/44 (20%)
		KELCH repeat	514..558	CDD:276965	13/43 (30%)
		KELCH repeat	561..606	CDD:276965	13/48 (27%)
Klhl30	NP_081827.1	BTB_POZ	1..137	CDD:453885	47/130 (36%)
		PHA03098	29..494	CDD:222983	136/482 (28%)
		BACK_KLHL30	128..231	CDD:350544	38/102 (37%)
		Kelch 1	280..327		9/48 (19%)
		KELCH repeat	319..364	CDD:276965	9/44 (20%)
		Kelch 2	328..378		9/49 (18%)
		KELCH repeat	368..410	CDD:276965	16/45 (36%)
		Kelch 3	379..423		15/47 (32%)
		KELCH repeat	413..455	CDD:276965	8/41 (20%)
		Kelch 4	425..472		13/46 (28%)
		KELCH repeat	462..499	CDD:276965	13/41 (32%)
		Kelch 5	474..514		12/44 (27%)
		KELCH repeat	504..551	CDD:276965	15/55 (27%)
		Kelch 6	515..564		14/57 (25%)