Protein Alignment Keap1 and Kbtbd3

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_081238.2
• Gene: Kbtbd3 / 69149
• MGIID: 1916399
• Length: 607
• Species: Mus musculus
• Alignment Length: 592
• Identity: 134/592 - (22%)
• Similarity: 247/592 - (41%)
• Gaps: 97/592 - (16%)

  Fly    71 NYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQG 135
            ::.::.|.::...|...:..|..:.:|:|:.|.|:.||:|.|.:|:|||...:||.:...|.:..
Mouse    29 DHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITN 93

  Fly   136 VCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAE 200
            :...|:...|.:.|||:.|:|:..|......::..||..:..||..||.:.:...|.:.:...::
Mouse    94 LSSKAVKAFLDYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCLHLLSLSD 158

  Fly   201 QHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDE 265
            .:|..:|......|::.:|..:.:..:||:::...|...:..|||||.||..|..|||.|:||:.
Mouse   159 SYGSAQLFSHTLYFVQHHFHLLYKSSDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNL 223

  Fly   266 DNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCPGV-KERTP 329
            ::|...:.|::..||...|:.:.|::.:.|.:.|.|...|.:.:....|  .:....|: .:..|
Mouse   224 ESRQKHLPHLITKVRLHQLSEDTLQDYLLNEEYLLKSTNCFDIIVDAIK--CVQGSSGLFPDARP 286

  Fly   330 NTT-RMIFV----AGGFFRHSLDILEAYNVDDMTWTTLAN---LRIPRSGLGAAFLKGKFYAVGG 386
            :|| :.||:    ..|..:::.    .||:...:|..|..   :.:|.|.|.:  ...|.:..||
Mouse   287 STTEKYIFIHKTEENGENQYTF----CYNIKTDSWKILPQSHLIDLPGSSLSS--YGEKIFLTGG 345

  Fly   387 RNN--------NIGSSYDSDWVDRYSAVTETWRPC---------APMSVPR-HRVGVAVMDELMY 433
            ...        :|..||       :.|..:||..|         :.|..|| ....|..::.| :
Mouse   346 CKGKCCRRIRLHIAQSY-------HDATDQTWCYCPAKNEFFCVSAMKTPRTMHTSVMALNRL-F 402

  Fly   434 AVG----GSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIG-------GFDG 487
            .:|    ||..::....||.|:|....||.|.|:..............::|.:|       .|:
Mouse   403 VIGGKTRGSQDIKSLLDVESYNPLSREWTSVSPLPRGIYYPEASACQNIIYVLGSEVEIADAFN- 466

  Fly   488 NERLASVEC---YHPENNEWSFLPPLQTGRSGAGVAAINQY--------------IYVVGGFDGT 535
                .|::|   |:...::||.|           ||...|:              :|:.
Mouse   467 ----PSLDCFFKYNATTDQWSEL-----------VAEFGQFFHATLIKAVPVNCTLYIC------ 510

  Fly   536 RQLATVERYDTENDT--WDMVAPIQIARSALSLTPLDEKLYAIGG-FDGNNFLSIVEVYDPRTNT 597
             .|:|.:.|....||  |......:.|........:::|:|.:|| :..:.....|:||....:.
Mouse   511 -DLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGGDYAPDEITDEVQVYHSSRSE 574

  Fly   598 WTTGTPL 604
            |...:|:
Mouse   575 WEEVSPM 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	129/564 (23%)
		KELCH repeat	369..416	CDD:276965	12/63 (19%)
		KELCH repeat	420..463	CDD:276965	13/47 (28%)
		KELCH repeat	467..510	CDD:276965	9/52 (17%)
		KELCH repeat	514..558	CDD:276965	10/59 (17%)
		KELCH repeat	561..606	CDD:276965	9/45 (20%)
Kbtbd3	NP_081238.2	BTB_POZ_KBTBD3_BKLHD3	24..153	CDD:349580	33/123 (27%)
		PHA03098	38..582	CDD:222983	133/583 (23%)
		Kelch 1. /evidence=ECO:0000255	291..337		10/51 (20%)
		KELCH repeat	330..385	CDD:276965	12/63 (19%)
		Kelch 2. /evidence=ECO:0000255	339..390		12/57 (21%)
		KELCH repeat	389..437	CDD:276965	14/48 (29%)
		Kelch 3. /evidence=ECO:0000255	400..450		12/50 (24%)
		KELCH repeat	440..485	CDD:276965	8/49 (16%)
		Kelch 4. /evidence=ECO:0000255	452..502		12/65 (18%)
		KELCH repeat	537..582	CDD:276965	9/45 (20%)
		Kelch 5. /evidence=ECO:0000255	548..595		9/34 (26%)