DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Keap1 and KLHL1

DIOPT Version :9

Sequence 1:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_065917.1	Gene:	KLHL1 / 57626	HGNCID:	6352	Length:	748	Species:	Homo sapiens

Alignment Length:	617	Identity:	214/617 - (34%)
Similarity:	334/617 - (54%)	Gaps:	22/617 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PNHKGYPCRPEEAEMSNTSESCSISCGGRFGS-AHSTL--DDHDATDDDMTFCMSNYAKEALKMM 80
            |:.||...:..:.|..|:|::....||.|..| .||..  .|.|::..:..:...::|::..:.|
Human   138 PHEKGLVLQELKVEPDNSSQATGEGCGHRLSSTGHSMTPQSDLDSSSSEEFYQAVHHAEQTFRKM 202

  Fly    81 YMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRIL 145
            ........|.||:|.|.....|||::|||:.|.||.||||..:.|::...::::|:.|.|:..::
Human   203 ESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLV 267

  Fly   146 YFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKK 210
            .|.|||.:.:.|.|:..||.||.:.|:|.|::.||.||.:.|.|:|.:||..||:..||:||.|.
Human   268 QFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKV 332

  Fly   211 ANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHI 275
            |:.:...|..:|.:.:|||.|.|.:|..|:..|::||.:|..:::|::.|||||..:|...:..:
Human   333 AHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSML 397

  Fly   276 LGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFK------DLTLHKCPGVKERTPNTTRM 334
            |..:|...|.|..|.: ::|..:.:....|::.:.:..|      ..||.:.|..|.| .:|...
Human   398 LAFIRLPLLPPQILAD-LENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPR-KSTVGT 460

  Fly   335 IFVAGGFFRH-SLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSD 398
            ::..||...: ....:|.|::....|.....:...|...|.|.:..|.:.:|||:    .....:
Human   461 LYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRD----GLKTLN 521

  Fly   399 WVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPM 463
            .|:.|:..|:||....|||..||.:||.|::..:|||||..|..|.||||.:||...:||.|..|
Human   522 TVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASM 586

  Fly   464 HAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYV 528
            ...|..|||..:|..||::||.||:..|:|:|.|.|..|:|:...|:...|.|.|||..:.::|.
Human   587 SIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYA 651

  Fly   529 VGGFDG------TRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSI 587
            |||.|.      :|.|..|||||.:.|||.||||:.:.|.|:.:..|.::|||:||:||..:|:.
Human   652 VGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNT 716

  Fly   588 VEVYDPRTNTWTTGTPLKSGRSGHASAVIYQP 619
            :|.|||:||.||....|..||:|....||.||
Human   717 MESYDPQTNEWTQMASLNIGRAGACVVVIKQP 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	38/102 (37%)
		PHA03098	92..599	CDD:222983	186/519 (36%)
		BACK	192..294	CDD:285009	35/101 (35%)
		Kelch	335..379	CDD:128874	8/44 (18%)
		KELCH repeat	369..416	CDD:276965	12/46 (26%)
		Kelch	382..430	CDD:128874	16/47 (34%)
		KELCH repeat	420..463	CDD:276965	21/42 (50%)
		Kelch	433..476	CDD:128874	21/42 (50%)
		KELCH repeat	467..510	CDD:276965	18/42 (43%)
		Kelch	478..523	CDD:128874	19/44 (43%)
		KELCH repeat	514..558	CDD:276965	24/49 (49%)
		Kelch_1	514..556	CDD:279660	22/47 (47%)
		KELCH repeat	561..606	CDD:276965	20/44 (45%)
		Kelch	572..616	CDD:128874	20/43 (47%)
KLHL1	NP_065917.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..93
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..182		10/30 (33%)
		PHA03098	206..728	CDD:222983	188/527 (36%)
		Kelch 1	460..506		8/45 (18%)
		KELCH repeat	496..539	CDD:276965	12/46 (26%)
		Kelch 2	507..553		17/49 (35%)
		KELCH repeat	543..587	CDD:276965	21/43 (49%)
		Kelch 3	555..600		21/44 (48%)
		KELCH repeat	590..633	CDD:276965	18/42 (43%)
		Kelch 4	601..647		19/45 (42%)
		KELCH repeat	637..687	CDD:276965	24/49 (49%)
		Kelch 5	649..700		22/50 (44%)
		KELCH repeat	690..734	CDD:276965	19/43 (44%)
		Kelch 6	701..747		22/45 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820