DRSC/TRiP Functional Genomics Resources

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Protein Alignment Keap1 and KLHL1

DIOPT Version :10

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_065917.1 Gene:KLHL1 / 57626 HGNCID:6352 Length:748 Species:Homo sapiens


Alignment Length:617 Identity:214/617 - (34%)
Similarity:334/617 - (54%) Gaps:22/617 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 PNHKGYPCRPEEAEMSNTSESCSISCGGRFGS-AHSTL--DDHDATDDDMTFCMSNYAKEALKMM 80
            |:.||...:..:.|..|:|::....||.|..| .||..  .|.|::..:..:...::|::..:.|
Human   138 PHEKGLVLQELKVEPDNSSQATGEGCGHRLSSTGHSMTPQSDLDSSSSEEFYQAVHHAEQTFRKM 202

  Fly    81 YMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRIL 145
            ........|.||:|.|.....|||::|||:.|.||.||||..:.|::...::::|:.|.|:..::
Human   203 ESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLV 267

  Fly   146 YFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKK 210
            .|.|||.:.:.|.|:..||.||.:.|:|.|::.||.||.:.|.|:|.:||..||:..||:||.|.
Human   268 QFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKV 332

  Fly   211 ANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHI 275
            |:.:...|..:|.:.:|||.|.|.:|..|:..|::||.:|..:::|::.|||||..:|...:..:
Human   333 AHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSML 397

  Fly   276 LGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFK------DLTLHKCPGVKERTPNTTRM 334
            |..:|...|.|..|.: ::|..:.:....|::.:.:..|      ..||.:.|..|.| .:|...
Human   398 LAFIRLPLLPPQILAD-LENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPR-KSTVGT 460

  Fly   335 IFVAGGFFRH-SLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSD 398
            ::..||...: ....:|.|::....|.....:...|...|.|.:..|.:.:|||:    .....:
Human   461 LYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRD----GLKTLN 521

  Fly   399 WVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPM 463
            .|:.|:..|:||....|||..||.:||.|::..:|||||..|..|.||||.:||...:||.|..|
Human   522 TVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASM 586

  Fly   464 HAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYV 528
            ...|..|||..:|..||::||.||:..|:|:|.|.|..|:|:...|:...|.|.|||..:.::|.
Human   587 SIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYA 651

  Fly   529 VGGFDG------TRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSI 587
            |||.|.      :|.|..|||||.:.|||.||||:.:.|.|:.:..|.::|||:||:||..:|:.
Human   652 VGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNT 716

  Fly   588 VEVYDPRTNTWTTGTPLKSGRSGHASAVIYQP 619
            :|.|||:||.||....|..||:|....||.||
Human   717 MESYDPQTNEWTQMASLNIGRAGACVVVIKQP 748

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 PHA03098 92..599 CDD:222983 186/519 (36%)
KELCH repeat 369..416 CDD:276965 12/46 (26%)
KELCH repeat 420..463 CDD:276965 21/42 (50%)
KELCH repeat 467..510 CDD:276965 18/42 (43%)
KELCH repeat 514..558 CDD:276965 24/49 (49%)
KELCH repeat 561..606 CDD:276965 20/44 (45%)
KLHL1NP_065917.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..93
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 151..182 10/30 (33%)
PHA03098 206..728 CDD:222983 188/527 (36%)
Kelch 1 460..506 8/45 (18%)
KELCH repeat 496..539 CDD:276965 12/46 (26%)
Kelch 2 507..553 17/49 (35%)
KELCH repeat 543..587 CDD:276965 21/43 (49%)
Kelch 3 555..600 21/44 (48%)
KELCH repeat 590..633 CDD:276965 18/42 (43%)
Kelch 4 601..647 19/45 (42%)
KELCH repeat 637..687 CDD:276965 24/49 (49%)
Kelch 5 649..700 22/50 (44%)
KELCH repeat 690..734 CDD:276965 19/43 (44%)
Kelch 6 701..747 22/45 (49%)
Blue background indicates that the domain is not in the aligned region.

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