Protein Alignment Keap1 and KLHL1

DIOPT Version :8

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_065917.1
• Gene: KLHL1 / 57626
• HGNCID: 6352
• Length: 748
• Species: Homo sapiens
• Alignment Length: 617
• Identity: 214/618 (35%)
• Similarity: 334/618 (54%)
• Gaps: 22/618 (4%)

  Fly    19 PNHKGYPCRPEEAEMSNTSESCSISCGGRFGS-AHSTL--DDHDATDDDMTFCMSNYAKEALKMM 80
            |:.||...:..:.|..|:|::....||.|..| .||..  .|.|::..:..:...::|::..:.|
Human   138 PHEKGLVLQELKVEPDNSSQATGEGCGHRLSSTGHSMTPQSDLDSSSSEEFYQAVHHAEQTFRKM 202

  Fly    81 YMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRIL 145
            ........|.||:|.|.....|||::|||:.|.||.||||..:.|::...::::|:.|.|:..::
Human   203 ESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLV 267

  Fly   146 YFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKK 210
            .|.|||.:.:.|.|:..||.||.:.|:|.|::.||.||.:.|.|:|.:||..||:..||:||.|.
Human   268 QFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKV 332

  Fly   211 ANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHI 275
            |:.:...|..:|.:.:|||.|.|.:|..|:..|::||.:|..:::|::.|||||..:|...:..:
Human   333 AHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSML 397

  Fly   276 LGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFK------DLTLHKCPGVKERTPNTTRM 334
            |..:|...|.|..|.: ::|..:.:....|::.:.:..|      ..||.:.|..|.| .:|...
Human   398 LAFIRLPLLPPQILAD-LENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPR-KSTVGT 460

  Fly   335 IFVAGGFFRH-SLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSD 398
            ::..||...: ....:|.|::....|.....:...|...|.|.:..|.:.:|||:    .....:
Human   461 LYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRD----GLKTLN 521

  Fly   399 WVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPM 463
            .|:.|:..|:||....|||..||.:||.|::..:|||||..|..|.||||.:||...:||.|..|
Human   522 TVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASM 586

  Fly   464 HAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYV 528
            ...|..|||..:|..||::||.||:..|:|:|.|.|..|:|:...|:...|.|.|||..:.::|.
Human   587 SIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYA 651

  Fly   529 VGGFDG------TRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSI 587
            |||.|.      :|.|..|||||.:.|||.||||:.:.|.|:.:..|.::|||:||:||..:|:.
Human   652 VGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNT 716

  Fly   588 VEVYDPRTNTWTTGTPLKSGRSGHASAVIYQP 619
            :|.|||:||.||....|..||:|....||.||
Human   717 MESYDPQTNEWTQMASLNIGRAGACVVVIKQP 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	39/103 (38%)
		PHA03098	92..599	CDD:222983	187/520 (36%)
		BACK	192..294	CDD:285009	35/102 (34%)
		Kelch	335..379	CDD:128874	8/45 (18%)
		KELCH repeat	369..416	CDD:276965	13/47 (28%)
		Kelch	382..430	CDD:128874	16/48 (33%)
		KELCH repeat	420..463	CDD:276965	21/43 (49%)
		Kelch	433..476	CDD:128874	21/43 (49%)
		KELCH repeat	467..510	CDD:276965	19/43 (44%)
		Kelch	478..523	CDD:128874	19/45 (42%)
		KELCH repeat	514..558	CDD:276965	24/50 (48%)
		Kelch_1	514..556	CDD:279660	23/48 (48%)
		KELCH repeat	561..606	CDD:276965	20/45 (44%)
		Kelch	572..616	CDD:128874	21/44 (48%)
KLHL1	NP_065917.1	BTB	202..305	CDD:279045	39/103 (38%)
		PHA03098	206..728	CDD:222983	189/528 (36%)
		BACK	314..413	CDD:285009	35/99 (35%)
		Kelch 1	460..506		8/46 (17%)
		Kelch	461..506	CDD:128874	8/45 (18%)
		Kelch_1	495..540	CDD:279660	14/49 (29%)
		KELCH repeat	496..539	CDD:276965	13/47 (28%)
		Kelch 2	507..553		17/50 (34%)
		KELCH repeat	543..587	CDD:276965	22/44 (50%)
		Kelch	555..600	CDD:128874	22/45 (49%)
		Kelch 3	555..600		22/45 (49%)
		KELCH repeat	590..633	CDD:276965	19/43 (44%)
		Kelch	601..647	CDD:128874	19/46 (41%)
		Kelch 4	601..647		19/46 (41%)
		KELCH repeat	637..687	CDD:276965	24/50 (48%)
		Kelch	649..700	CDD:128874	22/51 (43%)
		Kelch 5	649..700		22/51 (43%)
		KELCH repeat	690..734	CDD:276965	20/44 (45%)
		Kelch 6	701..747		22/46 (48%)
		Kelch	701..745	CDD:128874	21/44 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010