DRSC/TRiP Functional Genomics Resources

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Protein Alignment Keap1 and KLHL8

DIOPT Version :10

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_065854.3 Gene:KLHL8 / 57563 HGNCID:18644 Length:620 Species:Homo sapiens


Alignment Length:610 Identity:188/610 - (30%)
Similarity:317/610 - (51%) Gaps:46/610 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 STLDDHDATDDDMTFCMSNYAKEALKMMY--MMR--SHGMLTDVVLEVKKELFPAHKVVLSAASP 113
            |::.|.|. :|...|    .|.||.|..:  ::|  .:|.|.||.|:|..:|...||:||:...|
Human    31 SSISDGDG-EDSFIF----EANEAWKDFHGSLLRFYENGELCDVTLKVGSKLISCHKLVLACVIP 90

  Fly   114 YFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDA 178
            ||:|||...:.|::.:.::::.....|:..::.|:|:.::.:|...|..||.||.:.||..|..|
Human    91 YFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARA 155

  Fly   179 CCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRD 243
            ||.:::....|:|.:.:..|||.|..::|...|:.:...:||:|.:.|:|:.:|...|..|:...
Human   156 CCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSS 220

  Fly   244 ELNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREY 308
            :||::.|::||||.:||:..:..:....::..|..||...|..:||...:....::::...||:.
Human   221 DLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDL 285

  Fly   309 LAKIFKDLTLH----KCPGVK---ERTP--NTTRMIFVAGGF------FRHSLDILEAYNVDDMT 358
            |.:. ::..||    ..|..:   ..||  :|..::|..||.      ||.    :|.|:::..:
Human   286 LDEA-RNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRS----IECYSINKNS 345

  Fly   359 WTTLANLRIPRSGLGAAFLKGKFYAVGGR--NNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRH 421
            |.....:...|..:|...::||.|||||.  |.::||      ::.:..:|..|...|.|:..|.
Human   346 WFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGS------MEMFDPLTNKWMMKASMNTKRR 404

  Fly   422 RVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFD 486
            .:.:|.:...:||:||.......|.||.||.:.|:|:.|.||:..|.|||.|.:...:||:||.|
Human   405 GIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGND 469

  Fly   487 GNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTW 551
            |...|:|||.|.|..::|..:..:...|:|.||:.::..:|||||||....|::|||||..::.|
Human   470 GMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKW 534

  Fly   552 DMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVI 616
            |.||.:...|..:.:..:..|::|:||.:||.:|:.||.:||..|.|.....:...|:|...||.
Human   535 DYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVC 599

  Fly   617 YQPACSTTFMDYEDSDAPHPDGSNN 641
               :|.|:    :..|..|  ||||
Human   600 ---SCLTS----QIRDVGH--GSNN 615

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 PHA03098 92..599 CDD:222983 162/523 (31%)
KELCH repeat 369..416 CDD:276965 15/48 (31%)
KELCH repeat 420..463 CDD:276965 14/42 (33%)
KELCH repeat 467..510 CDD:276965 18/42 (43%)
KELCH repeat 514..558 CDD:276965 21/43 (49%)
KELCH repeat 561..606 CDD:276965 14/44 (32%)
KLHL8NP_065854.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..35 1/3 (33%)
BTB_POZ_KLHL8 52..171 CDD:349547 36/118 (31%)
PHA03098 60..535 CDD:222983 148/485 (31%)
Kelch 1 319..366 10/50 (20%)
KELCH repeat 356..399 CDD:276965 15/48 (31%)
Kelch 2 367..413 15/51 (29%)
KELCH repeat 403..447 CDD:276965 15/43 (35%)
Kelch 3 415..460 19/44 (43%)
KELCH repeat 450..495 CDD:276965 18/44 (41%)
Kelch 4 462..507 17/44 (39%)
KELCH repeat 497..542 CDD:276965 21/44 (48%)
Kelch 5 508..554 18/45 (40%)
KELCH repeat 544..586 CDD:276965 14/41 (34%)
Kelch 555..599 CDD:128874 16/43 (37%)
Kelch 6 556..601 16/47 (34%)

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