Protein Alignment Keap1 and klhl2

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_021331972.1
• Gene: klhl2 / 567966
• ZFINID: ZDB-GENE-090312-193
• Length: 590
• Species: Danio rerio
• Alignment Length: 562
• Identity: 207/562 - (36%)
• Similarity: 309/562 - (54%)
• Gaps: 21/562 - (3%)

  Fly    72 YAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGV 136
            :.|:|.::|..:||..:|.||.:..:.....||:|||:|.||||.|||||.:.||...:|:::.:
Zfish    35 HMKKAFRIMNELRSQSVLCDVTIIAEDVEIAAHRVVLAAGSPYFHAMFTGEMTESRQKKVRIKEI 99

  Fly   137 CPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQ 201
            ....:..::.::||.:|:|||..|..|||||.:.|:..|..|||.||..||.|||.:||..||:.
Zfish   100 DGWTLGMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQEVKKACCEFLITQLHPTNCLGIRAFADL 164

  Fly   202 HGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDED 266
            |.|.||...||.:.|::|::|.|.||||.|...|:.:||..|:|.:..|.:|:.||:.||.:|:|
Zfish   165 HACTELLNLANTYAEQHFSEVVQSEEFLNLGMDQVCSLIASDKLTIPSEEKVFEAVIAWVMHDKD 229

  Fly   267 NRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCPG-------- 323
            .|...:.|::..||...|:..:|.::::...:::...||::||.:..|   .|..|.
Zfish   230 VRQEHLAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMK---YHLLPADQRSMMKT 291

  Fly   324 --VKERTP-NTTRMIFVAGGFFRHSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVG 385
              .:.||| :..:::.|.||....::..:|.|:.::..|..:|.|...|...|..|:.|..||||
Zfish   292 IRTRVRTPISYPKVMMVVGGQAPKAIRSVECYDFEEERWFQVAELPSRRCRAGVVFMGGVVYAVG 356

  Fly   386 GRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYY 450
            |.|.::...    .||.|..|.:.|...:.|...|..:|.|.:..|:|||||..|.....|||.|
Zfish   357 GFNGSLRVR----TVDAYDPVKDEWCCVSSMQDRRSTLGCAFLSGLLYAVGGFDGSTGLATVEAY 417

  Fly   451 DPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNER--LASVECYHPENNEWSFLPPLQTG 513
            :...:.|..|.||:.:|..|||.||..||||:||:||..|  |::||.|:|..||||:...:.|.
Zfish   418 NAKANEWFHVNPMNTRRSSVGVGVVGGLLYAVGGYDGATRQCLSTVEAYNPNTNEWSYTAEMGTR 482

  Fly   514 RSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGG 578
            ||||||..:...:|.|||.||.....:.|.:|...:||..||.:.:.|....:..|...||.|||
Zfish   483 RSGAGVGVLKGLLYAVGGHDGPLVRKSCEVFDPATNTWKQVADMNMCRRNAGVCALSNLLYVIGG 547

  Fly   579 FDGNNFLSIVEVYDPRTNTWT-TGTPLKSGRSGHASAVIYQP 619
            .||:..|:.||.|:|.|:.|| ..|.:.:|||.....||.:|
Zfish   548 DDGSCNLASVEFYNPNTDKWTLLPTCMSTGRSYAGVTVIDKP 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	191/519 (37%)
		KELCH repeat	369..416	CDD:276965	15/46 (33%)
		KELCH repeat	420..463	CDD:276965	16/42 (38%)
		KELCH repeat	467..510	CDD:276965	24/44 (55%)
		KELCH repeat	514..558	CDD:276965	18/43 (42%)
		KELCH repeat	561..606	CDD:276965	18/45 (40%)
klhl2	XP_021331972.1	BTB_POZ	32..152	CDD:453885	47/116 (41%)
		PHA03098	53..569	CDD:222983	193/522 (37%)
		BACK_KLHL2_Mayven	150..279	CDD:350587	47/131 (36%)
		KELCH repeat	340..383	CDD:276965	15/46 (33%)
		KELCH repeat	483..527	CDD:276965	18/43 (42%)
		KELCH repeat	530..571	CDD:276965	17/40 (43%)