Protein Alignment Keap1 and klhl5

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_001164413.1
• Gene: klhl5 / 560697
• ZFINID: ZDB-GENE-080424-7
• Length: 769
• Species: Danio rerio
• Alignment Length: 638
• Identity: 221/638 - (34%)
• Similarity: 335/638 - (52%)
• Gaps: 50/638 - (7%)

  Fly     1 MQTQMHSPMQ--YETHISDMPNHKGYPCRPEEAEMSNTSESCSISCGGRFGSAHSTLDDHDATD- 62
            :|.|...|.|  .:...:..|:..|    |.:.|.:|..||.|.||  |..::..||....:.:
Zfish   146 LQQQPQQPQQQPQKQQSTRAPDASG----PGDEENNNNVESDSSSC--RTSNSSVTLSSCASMEP 204

  Fly    63 --DDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKE 125
              .|..|...::|:...:.|........|.||||.......|||::|||:.|.||.||||..::|
Zfish   205 CVSDEHFQAHSHAEHTFRRMEAYLRTRKLCDVVLLAGDRRIPAHRLVLSSVSDYFAAMFTSDVRE 269

  Fly   126 SEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPT 190
            ::...::::||.|.|:..::.:.|||::.:.|.|:..||..:.:.|:..|:.|||::|.:||.|:
Zfish   270 AKQEEIKMEGVDPDALWVLVQYAYTGRLELREDTIESLLSGSCLLQLSAVVQACCSYLMKQLHPS 334

  Fly   191 NAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYN 255
            |.:||..||:..||::|.|.|:.:...:|.:|.:.:|||.|.:.::..|:..|::||.||..|..
Zfish   335 NCLGIRSFADAQGCLDLHKVAHNYTMEHFMEVMRHQEFLLLPSCEVEKLLASDDMNVPEEETVVT 399

  Fly   256 AVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHK 320
            |:|.||::|...|..::..:|..:|...|.|.||.:...| .:||....|:..:.:..|   .|.
Zfish   400 ALLSWVRHDVTTRQSQLSALLAHIRLPLLKPQFLADMEAN-PLLRDSVECQRLVMEAMK---YHL 460

  Fly   321 CPGVKERTP-----------NTTRMIFVAGGFFRHSLDI------LEAYNVDDMTWTTLANLRIP 368
            .|   ||.|           .|...:|..||     :|.      :|.|.:...||..:|.:...
Zfish   461 LP---ERRPLLQSPRTRPRKATVGALFAVGG-----MDATKGATSIEQYCLRRDTWRQVAVMSGR 517

  Fly   369 RSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMY 433
            |...|.|.|..:.|.||||:    .....:.|:.|:..:::|....|||..||.:||||::..||
Zfish   518 RLQFGVAVLDDRLYVVGGRD----GLKTLNTVECYNPRSKSWSVMPPMSTHRHGLGVAVLEGPMY 578

  Fly   434 AVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYH 498
            ||||..|..|.:|||.:||...:|:.|..|...|..|||.|:|..|||:||.||:..|.||||:.
Zfish   579 AVGGHDGWSYLSTVERWDPQARQWSFVASMATPRSTVGVAVLNSKLYAVGGRDGSSCLKSVECFD 643

  Fly   499 PENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFD------GTRQLATVERYDTENDTWDMVAPI 557
            |..|:||...|:...|.|.|||..|.::|.:||.|      .:|....|||||.:.|.|..|||:
Zfish   644 PHTNKWSSCAPMSKRRGGVGVATWNGFLYAIGGHDAPASSLASRLSDCVERYDPKTDMWTAVAPM 708

  Fly   558 QIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSG 610
            .::|.|:.:..|.::|||:||:||..:|:.||.|||:||.||...||..||:|
Zfish   709 SLSRDAVGVCLLGDRLYAVGGYDGQVYLNTVEAYDPQTNEWTQVAPLCLGRAG 761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	191/529 (36%)
		KELCH repeat	369..416	CDD:276965	12/46 (26%)
		KELCH repeat	420..463	CDD:276965	21/42 (50%)
		KELCH repeat	467..510	CDD:276965	22/42 (52%)
		KELCH repeat	514..558	CDD:276965	21/49 (43%)
		KELCH repeat	561..606	CDD:276965	22/44 (50%)
klhl5	NP_001164413.1	PHA03098	225..756	CDD:222983	196/546 (36%)
		KELCH repeat	518..561	CDD:276965	12/46 (26%)
		KELCH repeat	565..609	CDD:276965	21/43 (49%)
		KELCH repeat	612..655	CDD:276965	22/42 (52%)
		KELCH repeat	659..709	CDD:276965	21/49 (43%)
		KELCH repeat	712..755	CDD:276965	20/42 (48%)