DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Keap1 and klhl5

DIOPT Version :9

Sequence 1:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_001164413.1	Gene:	klhl5 / 560697	ZFINID:	ZDB-GENE-080424-7	Length:	769	Species:	Danio rerio

Alignment Length:	638	Identity:	221/638 - (34%)
Similarity:	335/638 - (52%)	Gaps:	50/638 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQTQMHSPMQ--YETHISDMPNHKGYPCRPEEAEMSNTSESCSISCGGRFGSAHSTLDDHDATD- 62
            :|.|...|.|  .:...:..|:..|    |.:.|.:|..||.|.||  |..::..||....:.:
Zfish   146 LQQQPQQPQQQPQKQQSTRAPDASG----PGDEENNNNVESDSSSC--RTSNSSVTLSSCASMEP 204

  Fly    63 --DDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKE 125
              .|..|...::|:...:.|........|.||||.......|||::|||:.|.||.||||..::|
Zfish   205 CVSDEHFQAHSHAEHTFRRMEAYLRTRKLCDVVLLAGDRRIPAHRLVLSSVSDYFAAMFTSDVRE 269

  Fly   126 SEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPT 190
            ::...::::||.|.|:..::.:.|||::.:.|.|:..||..:.:.|:..|:.|||::|.:||.|:
Zfish   270 AKQEEIKMEGVDPDALWVLVQYAYTGRLELREDTIESLLSGSCLLQLSAVVQACCSYLMKQLHPS 334

  Fly   191 NAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYN 255
            |.:||..||:..||::|.|.|:.:...:|.:|.:.:|||.|.:.::..|:..|::||.||..|..
Zfish   335 NCLGIRSFADAQGCLDLHKVAHNYTMEHFMEVMRHQEFLLLPSCEVEKLLASDDMNVPEEETVVT 399

  Fly   256 AVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHK 320
            |:|.||::|...|..::..:|..:|...|.|.||.:...| .:||....|:..:.:..|   .|.
Zfish   400 ALLSWVRHDVTTRQSQLSALLAHIRLPLLKPQFLADMEAN-PLLRDSVECQRLVMEAMK---YHL 460

  Fly   321 CPGVKERTP-----------NTTRMIFVAGGFFRHSLDI------LEAYNVDDMTWTTLANLRIP 368
            .|   ||.|           .|...:|..||     :|.      :|.|.:...||..:|.:...
Zfish   461 LP---ERRPLLQSPRTRPRKATVGALFAVGG-----MDATKGATSIEQYCLRRDTWRQVAVMSGR 517

  Fly   369 RSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMY 433
            |...|.|.|..:.|.||||:    .....:.|:.|:..:::|....|||..||.:||||::..||
Zfish   518 RLQFGVAVLDDRLYVVGGRD----GLKTLNTVECYNPRSKSWSVMPPMSTHRHGLGVAVLEGPMY 578

  Fly   434 AVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYH 498
            ||||..|..|.:|||.:||...:|:.|..|...|..|||.|:|..|||:||.||:..|.||||:.
Zfish   579 AVGGHDGWSYLSTVERWDPQARQWSFVASMATPRSTVGVAVLNSKLYAVGGRDGSSCLKSVECFD 643

  Fly   499 PENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFD------GTRQLATVERYDTENDTWDMVAPI 557
            |..|:||...|:...|.|.|||..|.::|.:||.|      .:|....|||||.:.|.|..|||:
Zfish   644 PHTNKWSSCAPMSKRRGGVGVATWNGFLYAIGGHDAPASSLASRLSDCVERYDPKTDMWTAVAPM 708

  Fly   558 QIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSG 610
            .::|.|:.:..|.::|||:||:||..:|:.||.|||:||.||...||..||:|
Zfish   709 SLSRDAVGVCLLGDRLYAVGGYDGQVYLNTVEAYDPQTNEWTQVAPLCLGRAG 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	36/102 (35%)
		PHA03098	92..599	CDD:222983	191/529 (36%)
		BACK	192..294	CDD:285009	34/101 (34%)
		Kelch	335..379	CDD:128874	13/49 (27%)
		KELCH repeat	369..416	CDD:276965	12/46 (26%)
		Kelch	382..430	CDD:128874	17/47 (36%)
		KELCH repeat	420..463	CDD:276965	21/42 (50%)
		Kelch	433..476	CDD:128874	20/42 (48%)
		KELCH repeat	467..510	CDD:276965	22/42 (52%)
		Kelch	478..523	CDD:128874	22/44 (50%)
		KELCH repeat	514..558	CDD:276965	21/49 (43%)
		Kelch_1	514..556	CDD:279660	19/47 (40%)
		KELCH repeat	561..606	CDD:276965	22/44 (50%)
		Kelch	572..616	CDD:128874	22/39 (56%)
klhl5	NP_001164413.1	BTB	224..327	CDD:279045	36/102 (35%)
		PHA03098	225..756	CDD:222983	196/546 (36%)
		BACK	336..435	CDD:285009	34/98 (35%)
		Kelch	483..528	CDD:128874	13/49 (27%)
		KELCH repeat	518..561	CDD:276965	12/46 (26%)
		Kelch	529..575	CDD:128874	17/49 (35%)
		KELCH repeat	565..609	CDD:276965	21/43 (49%)
		Kelch	578..621	CDD:128874	20/42 (48%)
		KELCH repeat	612..655	CDD:276965	22/42 (52%)
		Kelch	623..669	CDD:128874	22/45 (49%)
		KELCH repeat	659..709	CDD:276965	21/49 (43%)
		Kelch	671..722	CDD:128874	18/50 (36%)
		KELCH repeat	712..755	CDD:276965	20/42 (48%)
		Kelch	723..767	CDD:128874	22/39 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820