Protein Alignment Keap1 and KLHL18

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Alignment Length: 568
• Identity: 204/568 - (35%)
• Similarity: 305/568 - (53%)
• Gaps: 55/568 - (9%)

  Fly    55 LDDHDATDDDMTFCMSNYAK---EALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFK 116
            |.|:...:|.  :.:..:.|   |:..:...:|..|.|.||.|:|:.:.|.||:|||:|..|||.
  Fly     3 LSDNSQVEDQ--YFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFY 65

  Fly   117 AMFTGGLKESEMSRVQLQ--GVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDAC 179
            ||||..:.||.:..:.::  .:.|:|:..::.::|:||:|:....|..|:..|:..|:.||.|||
  Fly    66 AMFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDAC 130

  Fly   180 CAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDE 244
            .:||..:..|.|.:||..||:...|.:|...|:.:|::||.:|.|.||||.|...||:.|:||||
  Fly   131 ASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDE 195

  Fly   245 LNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYL 309
            |||:.|..::.|.:|||||.||.|......:|.|||...|:|.||.:::...:::|....||:.|
  Fly   196 LNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLL 260

  Fly   310 --AKIFKDLTLHKCPGVKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDMTWTTLANLRIPRSGL 372
              ||.|     |..|   ||.                  .:|:::....            |||
  Fly   261 DEAKDF-----HLMP---ERR------------------GLLQSFRTRQ------------RSG- 286

  Fly   373 GAAFLKGKFYAVGGRNNNIGSSYDS-DWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVG 436
              .|..|:.|||||    :.|:.:| ..|:.|..:|:.|:....||:.|.||||||::..:||.|
  Fly   287 --EFFTGQIYAVGG----LASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFG 345

  Fly   437 GSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPEN 501
            |..|.|..:|||.|||..::|:....|..||..|||..::..:|..||:||...|.:||.|:|::
  Fly   346 GFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKS 410

  Fly   502 NEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSL 566
            |.|..:..:...||..||..:|.|:|.:||.||.....:|||||...|.|..::|:...|..|.:
  Fly   411 NTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGV 475

  Fly   567 TPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASA 614
            ..|:.|:|..||:.||:||..||.|||:|:||...||:...||..|.|
  Fly   476 ATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALA 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	188/511 (37%)
		KELCH repeat	369..416	CDD:276965	16/47 (34%)
		KELCH repeat	420..463	CDD:276965	20/42 (48%)
		KELCH repeat	467..510	CDD:276965	16/42 (38%)
		KELCH repeat	514..558	CDD:276965	19/43 (44%)
		KELCH repeat	561..606	CDD:276965	21/44 (48%)
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	42/116 (36%)
		PHA03098	36..510	CDD:222983	192/518 (37%)
		KELCH repeat	329..372	CDD:276965	20/42 (48%)
		KELCH repeat	376..417	CDD:276965	16/40 (40%)
		KELCH repeat	423..466	CDD:276965	18/42 (43%)
		KELCH repeat	470..514	CDD:276965	21/43 (49%)
		Kelch_1	517..560	CDD:396078	4/7 (57%)
		KELCH repeat	517..560	CDD:276965	4/7 (57%)