Protein Alignment Keap1 and kel-8

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_001300209.1
• Gene: kel-8 / 3565011
• WormBaseID: WBGene00020952
• Length: 727
• Species: Caenorhabditis elegans
• Alignment Length: 628
• Identity: 180/628 - (28%)
• Similarity: 307/628 - (48%)
• Gaps: 44/628 - (7%)

  Fly    20 NHKGY--PCRPEEAEMSNTSESCSISCGGRFGS-AHSTLDDHDATDDDMTFCM----SNYAKEAL 77
            |.||.  |.|.|..:..:|::..   ..|:... :::..::.:...:....||    ...:.:.:
 Worm    74 NEKGLYRPVRLENGDQISTTDDV---LNGKLARVSYTPFEEFELVSNSKGSCMEYENQEQSSKIM 135

  Fly    78 KMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMS 142
            :.|.::|....|.||.|.|...:..||:.:|:|||||||||||.|:.|.:...::||.:...::.
 Worm   136 EQMRILRQTEELCDVELLVAGSVIRAHRYILAAASPYFKAMFTNGMVEMKKLTIELQDIPEESVR 200

  Fly   143 RILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVEL 207
            .|:.::||.:|.:|...|.||:..||:.|:..::.||..||...:...|.:.:.||::.:.|..|
 Worm   201 IIVDYIYTDKIAITMNNVHQLIFTATVLQMDVIVVACQQFLATMITSHNCMSLYHFSDIYNCTNL 265

  Fly   208 QKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKM 272
            ......|....|..:.:..||..:|.:.|.:|:.|.:|||.||::|:..:::||..:..:|....
 Worm   266 ISSIEDFASSQFRCIRKSPEFNSISFHHLKSLLNRSDLNVSEEQDVFETIVQWVSSNPRDRQHHF 330

  Fly   273 EHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKD-LTLHK---------------- 320
            ..:...:|...:..|||.|.:.:...::....|||.::.:..| :|..|
 Worm   331 VQLFKTLRLHLVGWNFLCEAVNSNSYVKNSQECREIISAMVLDAMTPSKRKHPESNHENTSEYSA 395

  Fly   321 ---CPGVKERTPNTTR--------MIFVAGGFFRHS--LDILEAYNVDDMTWTTLANLRIPRSGL 372
               ||.:...:.::|.        .||.|||..:..  ...:|||:.....|..:.::...|..:
 Worm   396 SMACPSLTASSSSSTSTFRKSVAGAIFCAGGRGKAGGPFSSVEAYDWRRNQWIEVPDMMSQRRHV 460

  Fly   373 GAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGG 437
            |.....|..||:||.:   |:::.:. .:.:......|:..|.|...|..:.||.::.::|||||
 Worm   461 GVVSANGNLYAIGGHD---GTAHLAT-AEAFQPSIRQWKRIASMKTARRGIAVASIENVIYAVGG 521

  Fly   438 SAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENN 502
            ......:.|||.||.:.|.|:.|..|..:|.||||.|:.|.|:||||.||...|.:.|.:.|..:
 Worm   522 LDDTTCYKTVERYDIEEDEWSTVADMDVQRGGVGVAVIGRYLFAIGGNDGTSSLETCERFDPMID 586

  Fly   503 EWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLT 567
            :|..:..::..|:|:||..::.|:|.:||||....|.|.||||.:.|.|..:..:...|..:.:.
 Worm   587 KWKRIASMKNRRAGSGVCVLDGYLYAIGGFDDNAPLETCERYDPDADKWITLDKMSSPRGGVGVA 651

  Fly   568 PLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSG 610
            .|..|:|||||.||:::|:.||.|||..|.|.....:|..|:|
 Worm   652 ALGGKVYAIGGHDGSDYLNTVECYDPIANRWQPAAEIKECRAG 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	162/536 (30%)
		KELCH repeat	369..416	CDD:276965	10/46 (22%)
		KELCH repeat	420..463	CDD:276965	16/42 (38%)
		KELCH repeat	467..510	CDD:276965	18/42 (43%)
		KELCH repeat	514..558	CDD:276965	18/43 (42%)
		KELCH repeat	561..606	CDD:276965	18/44 (41%)
kel-8	NP_001300209.1	PHA03098	148..635	CDD:222983	145/490 (30%)
		KELCH repeat	457..500	CDD:276965	10/46 (22%)
		KELCH repeat	504..547	CDD:276965	16/42 (38%)
		KELCH repeat	551..595	CDD:276965	18/43 (42%)
		KELCH repeat	598..643	CDD:276965	18/44 (41%)
		KELCH repeat	645..687	CDD:276965	18/41 (44%)
		Kelch	656..698	CDD:128874	19/39 (49%)