Protein Alignment Keap1 and KLHL20

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_016856541.1
• Gene: KLHL20 / 27252
• HGNCID: 25056
• Length: 684
• Species: Homo sapiens
• Alignment Length: 631
• Identity: 233/631 - (36%)
• Similarity: 335/631 - (53%)
• Gaps: 44/631 - (6%)

  Fly     8 PMQYETHISDMPNHKGYPCRPEEAEMSNTSESCSISCGGRFGSAHSTLDDHDATDDD------MT 66
            ||:..|:|           ||.|..|..||.     |         ||.|.:...:.      |.
Human    80 PMRRCTNI-----------RPGETGMDVTSR-----C---------TLGDPNKLPEGVPQPARMP 119

  Fly    67 FCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRV 131
            :....:.::.|:::.::|.|..|.||||.|..:...||:|:|||.||||:|||||.|.||..:.|
Human   120 YISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEV 184

  Fly   132 QLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIA 196
            .::.:...||..::.|.||.||.|.|..|..|||||.:.|:..:.:|||.||:|||||:|.:||.
Human   185 VIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIR 249

  Fly   197 HFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWV 261
            .||:.|.|.||.:.|:.|.:.||.:|.:.|||:.|.|.|||.:|..|||||:.|.:|:|||:.||
Human   250 AFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWV 314

  Fly   262 KYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYL--AKIF----KDLTLHK 320
            ||....|..::..:|..||...|:|.||...:.:..:::....||:.:  ||.:    ::..|.:
Human   315 KYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQ 379

  Fly   321 CPGVKERTP-NTTRMIFVAGGFFR-HSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYA 383
            .|..:.|.| ....::|..||:.. .::..:|.|:.....|..:|::...|.|:|.:.|....||
Human   380 GPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYA 444

  Fly   384 VGGRNNNIGSSYDSDWVDRYSAVTETW-RPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTV 447
            |||.:   ||||.:. |:||...|..| ...||.|..|..|||||:...:|||||..|:...|.|
Human   445 VGGHD---GSSYLNS-VERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIV 505

  Fly   448 EYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQT 512
            |.|||..::||.|..|..:||||.|.|:...|||:||.||...|.:||.|:|:.|.|..:.|:.|
Human   506 ERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGT 570

  Fly   513 GRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIG 577
            .|...|.|.....||.|||.|.|.:|::.|||:...:.|..|..:...||.:.|..::.:|.|:|
Human   571 RRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVG 635

  Fly   578 GFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVIYQPACST 623
            ||||..:|..:||:||..|||.....:...|.|....||....|.:
Human   636 GFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVIKMTHCES 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	207/515 (40%)
		KELCH repeat	369..416	CDD:276965	19/47 (40%)
		KELCH repeat	420..463	CDD:276965	21/42 (50%)
		KELCH repeat	467..510	CDD:276965	20/42 (48%)
		KELCH repeat	514..558	CDD:276965	16/43 (37%)
		KELCH repeat	561..606	CDD:276965	18/44 (41%)
KLHL20	XP_016856541.1	BTB_POZ_KLHL20_KLEIP	120..247	CDD:349558	55/126 (44%)
		PHA03098	138..661	CDD:222983	211/526 (40%)
		KELCH repeat	430..474	CDD:276965	19/47 (40%)
		KELCH repeat	478..522	CDD:276965	21/43 (49%)
		KELCH repeat	525..570	CDD:276965	21/44 (48%)
		KELCH repeat	572..615	CDD:276965	16/42 (38%)
		KELCH repeat	619..664	CDD:276965	18/44 (41%)