Protein Alignment Keap1 and Klhl18

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_001347235.1
• Gene: Klhl18 / 270201
• MGIID: 2143315
• Length: 579
• Species: Mus musculus
• Alignment Length: 604
• Identity: 196/604 - (32%)
• Similarity: 298/604 - (49%)
• Gaps: 88/604 - (14%)

  Fly    56 DDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFT 120
            |..:..:|.:.|.:|........:|..:|..|.|.||.|::....|.||::||:|:.|||.||||
Mouse     4 DGAEELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFT 68

  Fly   121 GGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLER 185
            ..:.|.:...:.:||:.|:|:..::.|.|.|.:.:.:..|..||..|:..|:.::.||||.||..
Mouse    69 NDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRE 133

  Fly   186 QLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEE 250
            :|.|.|.:|:..|||...|..|...||.||.::|.:|...||||.|....::.|:.||||||:.|
Mouse   134 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSE 198

  Fly   251 REVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKD 315
            .:|:.|.|.||:||.:.|...:..:|..:|.....|.||.::::..|::|....||: |....||
Mouse   199 EQVFEAALAWVRYDREQRGPCLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRD-LVDEAKD 262

  Fly   316 LTLHKCPGVKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGK 380
              .|..|   ||.|:                  |.|:.......|::|               |.
Mouse   263 --YHLMP---ERRPH------------------LPAFRTRPRCCTSIA---------------GL 289

  Fly   381 FYAVGGRNN--NIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEY 443
            .|||||.|:  |..:....:.|:.:..:...|..|.||:..|.||||||::.|:||:||..|...
Mouse   290 IYAVGGLNSAANFYAGDSLNVVEVFDPIANRWEKCHPMTTARSRVGVAVVNGLLYAIGGYDGQLR 354

  Fly   444 HNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLP 508
            .:|||.|:|:.|.||.|..|::||..:|.||::..:|..||:|||..|.|||.|.||.::|:.:.
Mouse   355 LSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLNSVETYSPETDKWTVVT 419

  Fly   509 PLQTGRSGAGV-----------------------------------------------AAINQYI 526
            |:.:.||.|||                                               |::...:
Mouse   420 PMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAASMLNKRCRHGAASLGSKM 484

  Fly   527 YVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVY 591
            :|.||:||:..|:..|.|.:..|.|.::.|:...||.:||.....:|||:||:||.:.||.||:|
Mouse   485 FVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMY 549

  Fly   592 DPRTNTWTTGTPLKSGRSG 610
            ||.|:.||...|:.....|
Mouse   550 DPETDRWTFMAPMACHEGG 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	183/555 (33%)
		KELCH repeat	369..416	CDD:276965	11/48 (23%)
		KELCH repeat	420..463	CDD:276965	22/42 (52%)
		KELCH repeat	467..510	CDD:276965	18/42 (43%)
		KELCH repeat	514..558	CDD:276965	17/90 (19%)
		KELCH repeat	561..606	CDD:276965	22/44 (50%)
Klhl18	NP_001347235.1	BTB_POZ_KLHL18	19..134	CDD:349556	39/114 (34%)
		PHA03098	34..557	CDD:222983	186/561 (33%)
		BACK_KLHL18	135..241	CDD:350532	41/105 (39%)
		KELCH repeat	282..327	CDD:276965	13/59 (22%)
		KELCH repeat	331..374	CDD:276965	22/42 (52%)
		Kelch 2. /evidence=ECO:0000255	342..388		21/45 (47%)
		KELCH repeat	378..422	CDD:276965	19/43 (44%)
		Kelch 3. /evidence=ECO:0000255	389..435		20/45 (44%)
		KELCH repeat	425..469	CDD:276965	5/43 (12%)
		Kelch 4. /evidence=ECO:0000255	437..482		1/44 (2%)
		KELCH repeat	472..516	CDD:276965	12/43 (28%)
		Kelch 5. /evidence=ECO:0000255	484..529		15/44 (34%)
		KELCH repeat	519..562	CDD:276965	21/42 (50%)
		Kelch 6. /evidence=ECO:0000255	530..576		19/39 (49%)