Protein Alignment Keap1 and Klhl17

DIOPT Version :8

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_006239583.1
• Gene: Klhl17 / 246757
• RGDID: 708444
• Length: 650
• Species: Rattus norvegicus
• Alignment Length: 664
• Identity: 233/665 (35%)
• Similarity: 332/665 (50%)
• Gaps: 62/665 (9%)

  Fly     1 MQTQMHSP---MQYETHISDMPNHKGYP-----------CRPEEAEMSNTSESCS--ISCGGRFG 49
            ||.:...|   .|...|.|..|..:..|           .||.:|..:...|...  :|..|...
  Rat     1 MQPRGERPAGRTQSPEHSSPGPGPEAPPPPQPPAPEAERARPRQARPAAPMEGAMQLLSREGHSV 65

  Fly    50 SAHSTLDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPY 114
            :.:|....||                |...|..||..|:|.|:||.|..:...||||||::.|||
  Rat    66 AHNSKRHYHD----------------AFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPY 114

  Fly   115 FKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDAC 179
            |.||||..:.||..:.|.|..:.|.|:.:::.|.||.:|.|.|..|..|||||::.|:..|.|||
  Rat   115 FHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDAC 179

  Fly   180 CAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDE 244
            |.||..||||:|.:||..||:.|.|.:|.|.|:.::.::|..|.:.|||:.|...|::.|:..|.
  Rat   180 CKFLLSQLDPSNCLGIRGFADTHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDS 244

  Fly   245 LNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYL 309
            |||..|.:||.|||.|||:|.|.|...:..::..||...|:.:||...:....::|..|.|::.|
  Rat   245 LNVPSEEDVYRAVLSWVKHDVDTRRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLL 309

  Fly   310 AKIFKDLTLHKCPGV-------KERTPNTTRMIFVAGG---FFRHSLDILEAYNVDDMTWTTLAN 364
            .:..|...|.:..||       ..|......::|..||   |..|.  ..|||:.....|..:|:
  Rat   310 IEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHG--DCEAYDTRTDRWHVVAS 372

  Fly   365 LRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMD 429
            :...|:.:|.|.:..:.|||||.:   |:| |...|:.|..||.||:|...|...|..:|||.:.
  Rat   373 MSTRRARVGVAAVGNRLYAVGGYD---GTS-DLATVESYDPVTNTWQPEVSMGTRRSCLGVAALH 433

  Fly   430 ELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRL----------LYAIGG 484
            .|:||.||..|....|:.|.|||....||.:..|..:|..|.|..:...          |||:||
  Rat   434 GLLYAAGGYDGASCLNSAERYDPLTGTWTSIAAMSTRRRYVRVATLGASWVYCLPTDGNLYAVGG 498

  Fly   485 FDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTEND 549
            :|.:..||:||.|.|:.|.|:.:..:.:.||.||||.:...:||.||.|||..|.:||||.|:..
  Rat   499 YDSSSHLATVEKYEPQVNSWTPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSTKAG 563

  Fly   550 TWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASA 614
            .|:.|||:.|.||...|..:|..|||:||.||::.|:.:|.|:||||.|...:.:.:.||....|
  Rat   564 AWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVA 628

  Fly   615 VI----YQPACSTT 624
            |:    :.|..|.|
  Rat   629 VLELLNFPPPSSPT 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	48/103 (47%)
		PHA03098	92..599	CDD:222983	202/527 (38%)
		BACK	192..294	CDD:285009	38/102 (37%)
		Kelch	335..379	CDD:128874	13/47 (28%)
		KELCH repeat	369..416	CDD:276965	18/47 (38%)
		Kelch	382..430	CDD:128874	20/48 (42%)
		KELCH repeat	420..463	CDD:276965	17/43 (40%)
		Kelch	433..476	CDD:128874	16/43 (37%)
		KELCH repeat	467..510	CDD:276965	17/53 (32%)
		Kelch	478..523	CDD:128874	20/55 (36%)
		KELCH repeat	514..558	CDD:276965	23/44 (52%)
		Kelch_1	514..556	CDD:279660	22/42 (52%)
		KELCH repeat	561..606	CDD:276965	19/45 (42%)
		Kelch	572..616	CDD:128874	19/44 (43%)
Klhl17	XP_006239583.1	BTB	90..566	CDD:333434	180/482 (37%)
		KELCH repeat	377..420	CDD:276965	18/47 (38%)
		KELCH repeat	424..468	CDD:276965	18/44 (41%)
		KELCH repeat	471..526	CDD:276965	17/55 (31%)
		KELCH repeat	528..572	CDD:276965	23/44 (52%)
		KELCH repeat	575..620	CDD:276965	19/45 (42%)
		Kelch	587..631	CDD:128874	19/44 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010