DRSC/TRiP Functional Genomics Resources

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Protein Alignment Keap1 and Klhl17

DIOPT Version :10

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:XP_006239583.1 Gene:Klhl17 / 246757 RGDID:708444 Length:650 Species:Rattus norvegicus


Alignment Length:664 Identity:233/664 - (35%)
Similarity:332/664 - (50%) Gaps:62/664 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MQTQMHSP---MQYETHISDMPNHKGYP-----------CRPEEAEMSNTSESCS--ISCGGRFG 49
            ||.:...|   .|...|.|..|..:..|           .||.:|..:...|...  :|..|...
  Rat     1 MQPRGERPAGRTQSPEHSSPGPGPEAPPPPQPPAPEAERARPRQARPAAPMEGAMQLLSREGHSV 65

  Fly    50 SAHSTLDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPY 114
            :.:|....||                |...|..||..|:|.|:||.|..:...||||||::.|||
  Rat    66 AHNSKRHYHD----------------AFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPY 114

  Fly   115 FKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDAC 179
            |.||||..:.||..:.|.|..:.|.|:.:::.|.||.:|.|.|..|..|||||::.|:..|.|||
  Rat   115 FHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDAC 179

  Fly   180 CAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDE 244
            |.||..||||:|.:||..||:.|.|.:|.|.|:.::.::|..|.:.|||:.|...|::.|:..|.
  Rat   180 CKFLLSQLDPSNCLGIRGFADTHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDS 244

  Fly   245 LNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYL 309
            |||..|.:||.|||.|||:|.|.|...:..::..||...|:.:||...:....::|..|.|::.|
  Rat   245 LNVPSEEDVYRAVLSWVKHDVDTRRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLL 309

  Fly   310 AKIFKDLTLHKCPGV-------KERTPNTTRMIFVAGG---FFRHSLDILEAYNVDDMTWTTLAN 364
            .:..|...|.:..||       ..|......::|..||   |..|.  ..|||:.....|..:|:
  Rat   310 IEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHG--DCEAYDTRTDRWHVVAS 372

  Fly   365 LRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMD 429
            :...|:.:|.|.:..:.|||||.:   |:| |...|:.|..||.||:|...|...|..:|||.:.
  Rat   373 MSTRRARVGVAAVGNRLYAVGGYD---GTS-DLATVESYDPVTNTWQPEVSMGTRRSCLGVAALH 433

  Fly   430 ELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRL----------LYAIGG 484
            .|:||.||..|....|:.|.|||....||.:..|..:|..|.|..:...          |||:||
  Rat   434 GLLYAAGGYDGASCLNSAERYDPLTGTWTSIAAMSTRRRYVRVATLGASWVYCLPTDGNLYAVGG 498

  Fly   485 FDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTEND 549
            :|.:..||:||.|.|:.|.|:.:..:.:.||.||||.:...:||.||.|||..|.:||||.|:..
  Rat   499 YDSSSHLATVEKYEPQVNSWTPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSTKAG 563

  Fly   550 TWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASA 614
            .|:.|||:.|.||...|..:|..|||:||.||::.|:.:|.|:||||.|...:.:.:.||....|
  Rat   564 AWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVA 628

  Fly   615 VI----YQPACSTT 624
            |:    :.|..|.|
  Rat   629 VLELLNFPPPSSPT 642

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 PHA03098 92..599 CDD:222983 201/526 (38%)
KELCH repeat 369..416 CDD:276965 18/46 (39%)
KELCH repeat 420..463 CDD:276965 17/42 (40%)
KELCH repeat 467..510 CDD:276965 17/52 (33%)
KELCH repeat 514..558 CDD:276965 23/43 (53%)
KELCH repeat 561..606 CDD:276965 19/44 (43%)
Klhl17XP_006239583.1 BTB_POZ_KLHL17_actinfilin 51..189 CDD:349555 58/153 (38%)
PHA03098 90..566 CDD:222983 179/481 (37%)
BACK 187..288 CDD:475122 40/100 (40%)
KELCH repeat 377..420 CDD:276965 18/46 (39%)
KELCH repeat 424..468 CDD:276965 17/43 (40%)
KELCH repeat 471..526 CDD:276965 17/54 (31%)
KELCH repeat 528..572 CDD:276965 23/43 (53%)
KELCH repeat 575..620 CDD:276965 19/44 (43%)
Kelch 587..631 CDD:128874 19/43 (44%)

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