Protein Alignment Keap1 and Klhl34

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_001075136.1
• Gene: Klhl34 / 245683
• MGIID: 2685234
• Length: 644
• Species: Mus musculus
• Alignment Length: 656
• Identity: 152/656 - (23%)
• Similarity: 251/656 - (38%)
• Gaps: 107/656 - (16%)

  Fly    65 MTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMS 129
            :::| ..:....|.....:|:.|.|.||.||.:...||||:.:|:.:|.||:|:|....:||...
Mouse     5 LSYC-KTHGSSLLTGYQALRAEGFLCDVTLEAEGSEFPAHRSLLACSSDYFRALFKSHTQESRAR 68

  Fly   130 RVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIG 194
            .:.|:......:.|:|.|:||..:.::..||...|.||:..||...:..|..:|||||.|.|...
Mouse    69 VIHLRVPSAAGLQRLLDFIYTAWLPLSMDTVEDTLEAASYLQVTEALGLCAHYLERQLAPENCCF 133

  Fly   195 IAHFAEQHGCVELQKKANVFIERNFTQV----CQEEEFLQLSAYQLIALIRRDELNVQEEREVYN 255
            ||:.|.:.|.......|...|.|:...:    ......|:|:...:.|::...::....|..:..
Mouse   134 IANVAARFGLARTLGAAECCIVRHLGGLLLMGTGPSGLLELNPISMKAVLGAPDVARVPETRLLG 198

  Fly   256 AVLKWVKYDEDNRHCKMEH---ILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLT 317
            ..|.|::  ::.:..::.|   :||.:|...:....|:.......::  :|...:.|  |.:.|.
Mouse   199 LALAWLQ--QEPKVQRLAHSSTLLGCIRFGLVPAGVLRRIYSGSGLI--LPTRIKSL--IIQALN 257

  Fly   318 LHKCPG---------VKERTPNTTRMIFVAGGF------------------FRH----------- 344
            .|..|.         ...|:|.|  .|.:.||.                  .||
Mouse   258 YHTAPSSQPLLQGEQTSVRSPQT--RILLVGGLRAREMVTEEIMGLPEVVQNRHPAPQPEEEEGQ 320

  Fly   345 ------------SLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGR------NNNI 391
                        :.|:: :::|.:.:|.:|..|..|..|..........:.:||.      ::::
Mouse   321 EEEEMEEKEWELTQDVV-SFDVYNHSWHSLTQLPTPLLGHSVCTTGNFLFVLGGESLPGSPSSSL 384

  Fly   392 --GSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGM--EYHNTVEYYDP 452
              ||...:..|.||.....||.....|...|......|:.|.:.|||| .|:  |...:||.||.
Mouse   385 AAGSRSITALVHRYDPRFHTWTQVPAMREARAYFWCGVVGESLLAVGG-LGICGEALASVEMYDL 448

  Fly   453 DLDRW----TLVQPMHAKRLGVGVVVVNRLLYAIG-----GFDGNERLASVECYHPENNEWSFLP 508
            ..|||    .|.:.:|..   .|.|..:.::|..|     |..|...|..:....|....||...
Mouse   449 RRDRWMAAGQLPRAVHGH---AGAVGDHGVVYISGGKAGRGEGGTSSLRDMYSLSPGERVWSKRA 510

  Fly   509 PLQTGRSGAGVAAINQYIYVVGG----FDGTRQ-LATVERYDTENDTWDMVAPIQIARSALSLTP 568
            |:.|.|.|       .|:.|:.|    |.|..: .:.:||||...|.|..:..:...|....|..
Mouse   511 PMGTARYG-------HYLVVLRGAVFAFLGRYEPFSEIERYDPCTDQWTRLRSLPYDRFCYGLAV 568

  Fly   569 LDEKLYAIGGFDGNNFLSI----VEVYDPRTNTW-TTGTPLKSGRSGHASAVIYQPACSTTFMDY 628
            ::|.:..:||....:...:    |..||...:.| ..|..|....||...||:..|.......:.
Mouse   569 VEETVLLLGGLKWRDSRQVPTRNVVGYDLDLDRWEDIGCVLPWAWSGLQCAVLQLPEGREETREG 633

  Fly   629 EDSDAP 634
            |..:.|
Mouse   634 ETGEVP 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	137/592 (23%)
		KELCH repeat	369..416	CDD:276965	10/54 (19%)
		KELCH repeat	420..463	CDD:276965	17/48 (35%)
		KELCH repeat	467..510	CDD:276965	10/47 (21%)
		KELCH repeat	514..558	CDD:276965	13/48 (27%)
		KELCH repeat	561..606	CDD:276965	11/49 (22%)
Klhl34	NP_001075136.1	BTB_POZ_KLHL34	1..136	CDD:349573	43/131 (33%)
		BACK_KLHL34	126..233	CDD:350548	20/108 (19%)
		NanM	333..578	CDD:442289	63/256 (25%)
		KELCH repeat	358..411	CDD:276965	10/52 (19%)
		KELCH repeat	415..513	CDD:276965	29/101 (29%)
		KELCH repeat	516..559	CDD:276965	13/49 (27%)
		KELCH repeat	561..606	CDD:276965	9/44 (20%)