Protein Alignment Keap1 and Kbtbd7

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_001019306.2
• Gene: Kbtbd7 / 211255
• MGIID: 2685141
• Length: 690
• Species: Mus musculus
• Alignment Length: 570
• Identity: 154/570 - (27%)
• Similarity: 238/570 - (41%)
• Gaps: 118/570 - (20%)

  Fly    77 LKMMYMMRSHGMLTDVVLEV--------KKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQL 133
            ||..|..|   :|.||.:||        ...||..::.||:||.||||:|||||:.||:.:.|.:
Mouse    53 LKSFYDAR---LLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTI 114

  Fly   134 QGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHF 198
            ..|...:...::.:.|||::.::|..|.:|..|:.|.|:..|.:||.:||.|:||.||...|..|
Mouse   115 HDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKF 179

  Fly   199 AEQHGCVELQKKANVFIERNFTQV-----CQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVL 258
            |:.....:|:.:|..||..||.|:     .:||....|:..||:|::|.|.|:|:.|:.|.:..:
Mouse   180 ADAFDHHKLRSQAQSFIAHNFKQLSRMGSIREETLADLTLAQLLAVLRLDSLDVESEKTVCHVAV 244

  Fly   259 KWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCPG 323
            :|::.....|......:...:|    ..:|..|:             ::||..:...      |.
Mouse   245 QWLEAAPKERGPSAAEVFKCIR----WAHFPAEE-------------QDYLGGLLSK------PI 286

  Fly   324 VKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRN 388
            ||                 ::.|||:|.         .|..||.......:...|.........|
Mouse   287 VK-----------------KYCLDIIEG---------ALRQLRFGDRLYKSVVAKPNSSHSSDSN 325

  Fly   389 NNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEY--YD 451
            |:..||..|..|   .:|.|.         |..|:|:.. .|::...|       |....:  ||
Mouse   326 NSSNSSSSSSSV---VSVAEN---------PPQRLGMCA-KEMVIFFG-------HPRDPFLCYD 370

  Fly   452 P-DLDRWTLVQPM----HAKRLGVGVVVVNRLLYAIGGFDGNERLAS-----VECYHPENNEWSF 506
            | ..|.:|:..|:    |.|.:....|.|:.        |.:..||:     :..|.|..|.|..
Mouse   371 PYSGDIYTMPSPLTSLAHTKTITSSAVCVSP--------DHDIYLAAQPRKDLWVYKPAQNSWHQ 427

  Fly   507 LPPLQTGRSGAGVAAINQYIYVVGGFD---GTRQLATVERYDTENDTWDMVAPIQIARSALSLTP 568
            |......|.|..||.:|.|||::||.|   |.: |..||.|..:.:.|.:|||:..:..:..|..
Mouse   428 LADRLLCREGMDVAYLNGYIYILGGRDPITGVK-LKEVECYSVQRNQWALVAPVPHSFYSFELIV 491

  Fly   569 LDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVIYQ 618
            :...|||:   :....|    .|||..|.|.....||  ||....|.:::
Mouse   492 VQNYLYAV---NSKRML----CYDPSHNMWLNCASLK--RSDFQEACVFK 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	142/534 (27%)
		KELCH repeat	369..416	CDD:276965	9/46 (20%)
		KELCH repeat	420..463	CDD:276965	10/45 (22%)
		KELCH repeat	467..510	CDD:276965	10/47 (21%)
		KELCH repeat	514..558	CDD:276965	20/46 (43%)
		KELCH repeat	561..606	CDD:276965	11/44 (25%)
Kbtbd7	NP_001019306.2	BTB_POZ_KBTBD6_7	37..178	CDD:349582	48/127 (38%)
		PHA03098	55..554	CDD:222983	152/568 (27%)
		BACK_KBTBD6_7	168..270	CDD:350557	29/105 (28%)
		KELCH repeat	394..431	CDD:276965	10/44 (23%)
		KELCH repeat	435..481	CDD:276965	20/46 (43%)
		KELCH repeat	484..521	CDD:276965	10/43 (23%)
		KELCH repeat	522..561	CDD:276965	3/11 (27%)