Protein Alignment Keap1 and kel-10

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_001366684.1
• Gene: kel-10 / 176423
• WormBaseID: WBGene00002186
• Length: 578
• Species: Caenorhabditis elegans
• Alignment Length: 558
• Identity: 137/558 - (24%)
• Similarity: 222/558 - (39%)
• Gaps: 103/558 - (18%)

  Fly    92 VVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMS--RVQL-----------------QGVC 137
            :||...:|.|  .:.:||..|.||:.:|:...::|:.:  |::|                 ||:.
 Worm    55 LVLRNNEETF--DRCLLSFYSNYFRVLFSSKFRDSKSTTHRIRLISAPDLHLLLTIPKAFEQGIK 117

  Fly   138 PTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQ--VP--NVIDACCAFLERQLDPTNAIGIAHF 198
            |               .::.....:||..:...|  :|  .:.|..||.|..:    |.|.|...
 Worm   118 P---------------NISLQKAVELLEPSAFLQMSIPLDYITDVICANLTHE----NIIKIFRL 163

  Fly   199 AEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQ--EEREVYNAVLKWV 261
            |..:......:.....: |.|..:.....:|.|...:||.|:....||::  :|:.|   |:.|:
 Worm   164 ALLYHTTLAVRVWRAMV-RKFQTLFATNVYLTLKENELIGLLTDKHLNLKSADEKTV---VVNWI 224

  Fly   262 KYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCPGVKE 326
            |::...:..:|        .||...||.::..                    .|.|.::.  ::.
 Worm   225 KHNSPLQSDRM--------AQFAQRNFSRQPQ--------------------PDATKYEV--IRT 259

  Fly   327 RTPNTTRMIFVAGGF-FRHSLDILEAYNVDDMTWTT------LANLRIPRSGLGAAFLKGKFYAV 384
            |.|....:.|  ||: .|.....:|.:|.....|.|      :.|:|  |:..|...::.|....
 Worm   260 RQPMDAIVCF--GGWASRGVAQNIEVFNTRSDRWQTCNFNYDIPNIR--RAYHGIEVVEDKLIVY 320

  Fly   385 GGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDE-----LMYAVGGSAGMEYH 444
            ||.|   |:......| .:...|:.||..|.|:..|..|..|.:::     |::|.||..|:...
 Worm   321 GGFN---GTQQFQTTV-LFDLSTKEWRSGANMNDKRCYVTSARINDSHGRPLIFACGGMNGVSRL 381

  Fly   445 NTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPP 509
            .|.|.||...|:|:.|..|...|....||.::..:..||||||.......|.|.|..:.|..|..
 Worm   382 KTAEMYDYRADQWSEVANMAQMRSDGAVVTIDNKIVVIGGFDGRNIHQGGEVYDPVLDLWHPLSS 446

  Fly   510 -LQTGRSG-AGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDE- 571
             ::|.|:| ..|:.:||...::|||:|.|:|.:.|.||.....|..|..:..|||..|...:|.
 Worm   447 NMRTRRTGCTAVSIMNQVCMIIGGFNGNRRLDSAEIYDMREGLWHPVPSLHTARSNFSACQMDTC 511

  Fly   572 KLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRS 609
            .:|..|||||.......|..|.|:..|.....:...:|
 Worm   512 SIYVAGGFDGQATTKESERLDLRSKMWQALPDMSEAKS 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	135/546 (25%)
		KELCH repeat	369..416	CDD:276965	12/46 (26%)
		KELCH repeat	420..463	CDD:276965	15/47 (32%)
		KELCH repeat	467..510	CDD:276965	14/43 (33%)
		KELCH repeat	514..558	CDD:276965	16/44 (36%)
		KELCH repeat	561..606	CDD:276965	14/45 (31%)
kel-10	NP_001366684.1	BTB_POZ	41..145	CDD:453885	20/106 (19%)
		BACK	158..>227	CDD:197943	17/72 (24%)
		NanM	305..558	CDD:442289	76/249 (31%)
		KELCH repeat	305..348	CDD:276965	12/46 (26%)
		KELCH repeat	352..401	CDD:276965	15/48 (31%)
		KELCH repeat	404..446	CDD:276965	14/41 (34%)
		KELCH repeat	452..498	CDD:276965	16/45 (36%)
		KELCH repeat	500..546	CDD:276965	14/45 (31%)