Protein Alignment Keap1 and kel-20

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_491322.2
• Gene: kel-20 / 172012
• WormBaseID: WBGene00020030
• Length: 607
• Species: Caenorhabditis elegans
• Alignment Length: 600
• Identity: 207/600 - (34%)
• Similarity: 312/600 - (52%)
• Gaps: 29/600 - (4%)

  Fly    50 SAHSTLDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPY 114
            ::|.:.|..::......:..|::|...|:.:..:::..:|.||.|....:...||:|||||.|||
 Worm    16 TSHDSADMFESRKPQSKYKNSHFANSVLQQLGGLKNRDVLCDVTLICGWKRINAHRVVLSACSPY 80

  Fly   115 FKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDAC 179
            |.:|||..:.|..|..:.::.:.|..:..::.|.|||.|.:.:..|..:||||.:.|:..|..||
 Worm    81 FLSMFTSQMAECYMREINMEEIEPPTLEALIEFCYTGAIAIDDSNVQDILPAACLLQIHEVQTAC 145

  Fly   180 CAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDE 244
            |.:|::||||:|.:||..||:.|.|.||...|:.|..:||::|..:|||..|:...|..:|:.|:
 Worm   146 CDYLKKQLDPSNCLGIRAFADTHSCKELLSSADEFALKNFSRVIGKEEFQMLTVESLTTIIKSDK 210

  Fly   245 LNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYL 309
            ||...|..|::||::||::|...|...:..:|..||....||.||...:....:::..||.|:.:
 Worm   211 LNAASEELVFSAVIQWVRHDISKRKTHLSMLLSHVRLPLCTPKFLVSVVSEEILVKSDPASRDLV 275

  Fly   310 --AKIFKDLTLHK----CPGVKERTP-NTTRMIFVAGGFFRHSLDILEAYNVDDM----TWTTLA 363
              ||.:..|.:.:    .|..|.|.| ..:.:::..||:..... |.....:|.|    ||..:|
 Worm   276 DEAKNYLLLPVERPNMQGPRTKPRKPLQGSEVLYAVGGWCSGDA-IASIERLDPMKGGTTWKCVA 339

  Fly   364 NLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETW-RPCAPMSVPRHRVGVAV 427
            .:...|.|:|.|.|:...|||||.:   |.||.:. ::||..:|..| ...||.:..|..||||.
 Worm   340 PMGKRRCGVGVAVLENLLYAVGGHD---GQSYLNS-IERYDPMTNQWSSDVAPTATCRTSVGVAA 400

  Fly   428 MDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLA 492
            .:..:|||||..|....:.||.|||..:.|..|..|..:||||.|.|||..:||:||.:|...|.
 Worm   401 FNGSLYAVGGQDGESCLDVVEKYDPRKNEWAKVASMGTRRLGVSVSVVNGCIYAVGGSNGPAPLN 465

  Fly   493 SVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPI 557
            :||.|.|...:|..:.|:.|.|...|.|..:.|||.|||.|.|.:|.|.|||..|.|.|..|..:
 Worm   466 TVERYDPRVGKWEEVRPMLTKRKHLGTAVYDGYIYAVGGRDTTTELNTAERYSVERDEWQPVVAM 530

  Fly   558 QIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVIYQPACS 622
            ...||.:.:..:.|||||:|||||..:|..||::|..||.|.|.:.:...|.|....|:
 Worm   531 SNRRSGVGVAVVGEKLYAVGGFDGQTYLKSVEIFDKDTNRWKTHSQMFYRRLGGGVGVV------ 589

  Fly   623 TTFMDYEDSDAPHPD 637
                  ..:|||..:
 Worm   590 ------RVADAPETE 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	192/518 (37%)
		KELCH repeat	369..416	CDD:276965	18/47 (38%)
		KELCH repeat	420..463	CDD:276965	18/42 (43%)
		KELCH repeat	467..510	CDD:276965	19/42 (45%)
		KELCH repeat	514..558	CDD:276965	20/43 (47%)
		KELCH repeat	561..606	CDD:276965	20/44 (45%)
kel-20	NP_491322.2	PHA03098	56..572	CDD:222983	193/520 (37%)
		KELCH repeat	345..389	CDD:276965	18/47 (38%)
		KELCH repeat	393..437	CDD:276965	18/43 (42%)
		KELCH repeat	440..485	CDD:276965	20/44 (45%)
		KELCH repeat	487..531	CDD:276965	20/43 (47%)
		KELCH repeat	534..577	CDD:276965	20/42 (48%)