DRSC/TRiP Functional Genomics Resources

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Protein Alignment Keap1 and KBTBD12

DIOPT Version :10

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_997218.2 Gene:KBTBD12 / 166348 HGNCID:25731 Length:623 Species:Homo sapiens


Alignment Length:566 Identity:137/566 - (24%)
Similarity:242/566 - (42%) Gaps:93/566 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 LKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAM 141
            |..:..|:....:.||||..:.|.||.|::||:|.|||||||||.||.|.....|.|..:...::
Human    18 LNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESV 82

  Fly   142 SRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVE 206
            |.:|.:||...:.:....|..:..||...|:..|...|..::...:|.:|.:||.:||:|.|..:
Human    83 SVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGIYYFAKQIGAED 147

  Fly   207 LQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCK 271
            |..::..::.::|.:|...||.|::..:|.:.||:.|:||:..|..:.:.||:||.::::.|...
Human   148 LSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRTVH 212

  Fly   272 MEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDL-----------------TLH 319
            :..:|..||.:.:.|:||::.::...:|.....|.:.:...||.:                 :|.
Human   213 LVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQNAFKAIKTPQQHSLNLRYGMETTSLL 277

  Fly   320 KC-----PGVKER-----------TPNTTRMIFVAGGFFRHSLDI-------------------- 348
            .|     .|::.|           .|.:.:..|::...:...|..                    
Human   278 LCIGNNSSGIRSRHRSYGDASFCYDPVSRKTYFISSPKYGEGLGTVCTGVVMENNTIIVAGEASA 342

  Fly   349 ----------LEAYNVDD---MTWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWV 400
                      :|.|...|   ..|..|..... |.......:....|.:||:.........::.|
Human   343 SKLSRQKNKNVEIYRYHDRGNQFWEKLCTAEF-RELYALGSIHNDLYVIGGQMKIKNQYLITNCV 406

  Fly   401 DRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGG-SAGME--------YHNTVEYYDPDLDR 456
            |:||...:.|:..:|:.:......|..::..:|.:|| :..|:        ..|.:..|||..|:
Human   407 DKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQ 471

  Fly   457 WTLVQPMHAKRLGVGVVVVNRLLYAIGGFD--GNER------LASVECYHPENNEWSFLPP---- 509
            |::..||...:......|||..:|.:||..  |.::      |..||.|:|:.:.|...||    
Human   472 WSVRAPMKYSKYRFSTAVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSP 536

  Fly   510 ---LQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWD 552
               |:|..:.||  |::..:||.|||.|..:...:.:...|.|.|:
Human   537 LLSLRTNSTNAG--AVDGKLYVCGGFHGADRHEVISKEILELDPWE 580

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 PHA03098 92..599 CDD:222983 134/551 (24%)
KELCH repeat 369..416 CDD:276965 9/46 (20%)
KELCH repeat 420..463 CDD:276965 11/51 (22%)
KELCH repeat 467..510 CDD:276965 15/57 (26%)
KELCH repeat 514..558 CDD:276965 12/39 (31%)
KELCH repeat 561..606 CDD:276965
KBTBD12NP_997218.2 BTB_POZ_KBTBD12 10..136 CDD:349585 39/117 (33%)
PHA03098 29..586 CDD:222983 135/555 (24%)
BACK_KBTBD12 128..227 CDD:350560 29/98 (30%)
KELCH repeat 375..422 CDD:276965 9/46 (20%)
Kelch 1 386..436 10/49 (20%)
KELCH repeat 426..479 CDD:276965 12/52 (23%)
Kelch 2 437..492 14/54 (26%)
KELCH repeat 482..535 CDD:276965 15/52 (29%)
Kelch 3 494..547 14/52 (27%)
KELCH repeat 541..587 CDD:276965 13/42 (31%)
Kelch 4 553..603 9/28 (32%)
Blue background indicates that the domain is not in the aligned region.

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