DRSC/TRiP Functional Genomics Resources

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Protein Alignment Keap1 and KLHL33

DIOPT Version :10

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_001352719.1 Gene:KLHL33 / 123103 HGNCID:31952 Length:797 Species:Homo sapiens


Alignment Length:602 Identity:152/602 - (25%)
Similarity:243/602 - (40%) Gaps:97/602 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 KEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCP 138
            :|.|:.:.::...|:..|:.||........|:..|:..|.:|.||...|::||:.:.|.|:.:..
Human   221 RENLRGIELLYREGVGCDLKLEAGGCQLSVHRAALACGSEFFGAMLLSGMRESQGTEVSLRTIST 285

  Fly   139 TAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHG 203
            ..:..::.|.|:|.:|.....:.:...||..:|..:.:|.|...|.|.|.|...:.:...||..|
Human   286 QDLRLLVSFAYSGVVRARWPGLLRAAQAALQYQSSSCLDLCQKGLARGLSPARCLALFPMAEAPG 350

  Fly   204 CVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNR 268
            ...|..||..::..:...|.....|..|.|..|..|:..|||:||||.|.:.|...|:..:.:.:
Human   351 LERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAARCWLAANPETQ 415

  Fly   269 HCKMEHILGAVRCQF-------------------LTPNFLKEQMKNCDVLRKVPACREYLAKIFK 314
            ..:.:.:|..||  |                   |||:.|.:.|...||                
Human   416 ESEAKALLRCVR--FGRMSTRELRRVRAAGLLPPLTPDLLHQLMVEADV---------------- 462

  Fly   315 DLTLHKCPGVKERTPNTTRMIFVAGG--------------------FFRHSLDILEAYNVDDMTW 359
                   || :||.....|.:.|.||                    .||..:.:     |..:.|
Human   463 -------PG-QERRREPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGL-----VRTVEW 514

  Fly   360 TTLANLRIP-RSGLGAAFLKG-KFYAVGGR-----NNNIGSSYDSDWVDRYSAVTETWRPCAPMS 417
            ..|..|..| |...|||.|.| :.|..||:     :|.:.|:.      |:....|.|...||:|
Human   515 GQLPALPAPGRFRHGAASLAGSELYVCGGQDFYSHSNTLASTL------RWEPSQEDWEEMAPLS 573

  Fly   418 VPRHRVGVAVMDELMYAVGGSAGMEYHN-----TVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNR 477
            ..|....:..:|..:||:||.     ||     :||.|:|:|:.|.....:.|........::..
Human   574 QARSLFSLVALDGKLYALGGR-----HNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEG 633

  Fly   478 LLYAIGGFDG-NERLASVECYHPE-NNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLAT 540
            .||..||..| .:.|||:..|.|: ....:||.|:...|:|..:||:...:||.||...|..|.:
Human   634 QLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLS 698

  Fly   541 VERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNF-LS-IVEVYDPRTNTWTTGTP 603
            .|.|:...|:|..:||:.......:...|..:|..:||:....: || ::..|.|....|.....
Human   699 FEAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLGT 763

  Fly   604 LKSGRSGHASAVIYQPA 620
            |...|:...:.::..||
Human   764 LPRPRAEMPACILTLPA 780

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 PHA03098 92..599 CDD:222983 143/561 (25%)
KELCH repeat 369..416 CDD:276965 15/52 (29%)
KELCH repeat 420..463 CDD:276965 14/47 (30%)
KELCH repeat 467..510 CDD:276965 12/44 (27%)
KELCH repeat 514..558 CDD:276965 16/43 (37%)
KELCH repeat 561..606 CDD:276965 10/46 (22%)
KLHL33NP_001352719.1 BTB1_POZ_KLHL33 95..193 CDD:349571
BTB_POZ 224..341 CDD:453885 29/116 (25%)
BACK_KLHL33 334..408 CDD:350547 23/73 (32%)
NanM 512..774 CDD:442289 76/272 (28%)
KELCH repeat 525..574 CDD:276965 16/54 (30%)
KELCH repeat 576..619 CDD:276965 14/47 (30%)
KELCH repeat 623..669 CDD:276965 13/45 (29%)
KELCH repeat 672..717 CDD:276965 16/44 (36%)
KELCH repeat 719..765 CDD:276965 9/45 (20%)
Blue background indicates that the domain is not in the aligned region.

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