DRSC/TRiP Functional Genomics Resources

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Protein Alignment Keap1 and Klhl3

DIOPT Version :10

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_001349344.2 Gene:Klhl3 / 100503085 MGIID:2445185 Length:587 Species:Mus musculus


Alignment Length:555 Identity:203/555 - (36%)
Similarity:315/555 - (56%) Gaps:15/555 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 EALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPT 139
            :|.|:|..:||..:|.||::..:.....||:|||:|.||||.|||||.:.||:..:::::.|...
Mouse    35 KAFKVMNELRSKRLLCDVMIVAEDVEVEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQ 99

  Fly   140 AMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGC 204
            .:|:::.::||.:|.|||..|..|||||::.|:.:|...||.||:.||.|||.:||..||:.|.|
Mouse   100 TLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTC 164

  Fly   205 VELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRH 269
            .:|.::||.:.|::|.:|...||||.||..|:.:||..|:|.|..|.:|:.||:.|:.|:::.|.
Mouse   165 TDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKETRL 229

  Fly   270 CKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFK-------DLTLHKCPGVKER 327
            ..|..::..||...|..::|.:.::...:::....|:::|.:..|       ...|.|.|..|.|
Mouse   230 DHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPR 294

  Fly   328 TP-NTTRMIFVAGGFFRHSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNI 391
            || :..:::.|.||....::..:|.|:.::..|..:|.|...|...|..|:.|..|||||.|.::
Mouse   295 TPVSLPKVMIVVGGQAPKAIRSVECYDFEEGRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSL 359

  Fly   392 GSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDR 456
            ...    .||.|..|.:.|...|.|...|..:|.||:::|:|||||..|.....:||.|....:.
Mouse   360 RVR----TVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNE 420

  Fly   457 WTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNER--LASVECYHPENNEWSFLPPLQTGRSGAGV 519
            |..|.||:.:|..|||.||...|||:||:||..|  |::||.|:|..|||.::..:.|.||||||
Mouse   421 WFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGV 485

  Fly   520 AAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNF 584
            ..::..:|..||.||.....:||.||...:||..||.:.:.|....:..::..||.:||.||:..
Mouse   486 GVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN 550

  Fly   585 LSIVEVYDPRTNTWT-TGTPLKSGRSGHASAVIYQ 618
            |:.||.|:|.|:.|| ..|.:.:|||....|||::
Mouse   551 LASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVIHK 585

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 PHA03098 92..599 CDD:222983 187/516 (36%)
KELCH repeat 369..416 CDD:276965 16/46 (35%)
KELCH repeat 420..463 CDD:276965 16/42 (38%)
KELCH repeat 467..510 CDD:276965 22/44 (50%)
KELCH repeat 514..558 CDD:276965 19/43 (44%)
KELCH repeat 561..606 CDD:276965 16/45 (36%)
Klhl3NP_001349344.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
BTB_POZ_KLHL3 29..149 CDD:349648 47/113 (42%)
PHA03098 50..566 CDD:222983 189/519 (36%)
BACK_KLHL3 147..276 CDD:350588 43/128 (34%)
KELCH repeat 297..333 CDD:276965 7/35 (20%)
Kelch 1 302..347 11/44 (25%)
KELCH repeat 337..380 CDD:276965 16/46 (35%)
Kelch 2 348..394 17/49 (35%)
KELCH repeat 384..428 CDD:276965 17/43 (40%)
Kelch 3 396..441 19/44 (43%)
KELCH repeat 431..476 CDD:276965 22/44 (50%)
Kelch 4 442..490 23/47 (49%)
KELCH repeat 480..524 CDD:276965 19/43 (44%)
Kelch 5 491..537 14/45 (31%)
KELCH repeat 527..573 CDD:276965 16/45 (36%)
Kelch 6 539..585 21/45 (47%)
Blue background indicates that the domain is not in the aligned region.

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