Protein Alignment Keap1 and klhl22

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_003199199.2
• Gene: klhl22 / 100333714
• ZFINID: ZDB-GENE-081104-154
• Length: 625
• Species: Danio rerio
• Alignment Length: 651
• Identity: 180/651 - (27%)
• Similarity: 306/651 - (47%)
• Gaps: 72/651 - (11%)

  Fly    33 MSNTSESCSISCGGRFGSAHSTLDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVK 97
            |::...||::  ||...||....        ...:..:.:::..|..:.|:|..|:|.||||.|:
Zfish     1 MADDLVSCTV--GGAVRSAQPCA--------KQKYRSTAHSQGLLDGLLMLRQGGILFDVVLLVE 55

  Fly    98 KELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQ 162
            .:...||:::|:|:..||:.||.|||:|.:.:.:.:.||..|||.::|.|:||.::.:...||.:
Zfish    56 GKPIQAHRILLAASCDYFRGMFAGGLREMQQTEIPVHGVSYTAMMKLLDFIYTSELELDLDTVQE 120

  Fly   163 LLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEE 227
            :|.|||:.||.:||..||.||...||..|.:.:...|:.:|..:|.:|...::.:|.....:...
Zfish   121 VLCAATLLQVQDVIGFCCDFLFSWLDDDNILEVEKLADIYGLHQLGEKIRSYLLKNIQTFSRTPV 185

  Fly   228 FLQLSAYQLIALIRRDELNVQEEREVYNAVLKW---VKYDEDNRHCKME--HILGAVRCQFLTPN 287
            :.:|.|.::::::..:||.|..|.|||.|.|.:   .:..|.::.|..|  .:|.|||...:..:
Zfish   186 YRKLPAEKVLSVLCSNELEVDSENEVYEAALHYHYTPEQVEKDQVCLQEPLRMLEAVRFCLMEKH 250

  Fly   288 FLK---EQMKNCDVLRKVPACREYLAK------IFKDLTLHKCPGVKERTPNTTRMIFVAGGFFR 343
            .|:   .::|.|.:...|.|...|.::      :...|||.:|         :::.|...||.:.
Zfish   251 VLQRLHSRLKQCPLRDSVAAALRYHSQELWQPVMQTPLTLPRC---------SSQCIVGFGGMYA 306

  Fly   344 HS--LDILEAYNVDDMTWT---TLANLRIPR-SGLGAAFLKGKFYAVGGRNNNIGSSYDSD-WVD 401
            .|  :|..|.:.|...:|:   :||..|.|| |.:|.|.|....|.:||..|..|...::. |
Zfish   307 SSALVDNEERFQVFHPSWSEWRSLAAERAPRMSNMGIAVLNNFVYLIGGDKNTSGFRAEARCW-- 369

  Fly   402 RYSAVTETWRPCAPMSVPRHRVG--VAVMDELMYAVGGSAGMEYHN---TVEYYDPDLDRWTLVQ 461
            ||.....:|  |...|:.:....  |.|:|:.:||:|   |.:|.|   .||.|:|..:.|..:.
Zfish   370 RYDPRQNSW--CTVESLRQQHADHCVCVVDKYIYAIG---GRDYTNELDCVERYNPQTNTWEFMA 429

  Fly   462 PMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYI 526
            |:..:.......|::..:|...|..|...|....||.|.:|.||........|:..|:||:|:..
Zfish   430 PLKREVYAHAGAVIDGKIYISCGRRGMAYLKETYCYDPGSNHWSVCAEGPVERAWHGMAALNERA 494

  Fly   527 YVVGGFDGT----RQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGG--FDGNNFL 585
            ||:||.:.:    |.:..|..|:...|.|.:|:|:...........||.::|.:||  .|..:.:
Zfish   495 YVMGGSNDSCGYRRDVLKVACYNPTADVWSVVSPLPAGHGEPGTAVLDGRIYILGGRSHDKGSRM 559

  Fly   586 SIVEVYDPRTNTWTTGTPLKSGRSGHASAVIYQP--------------ACSTTFMDYEDSDAPHP 636
            ..|.:|....:.|.:||.|:...||.::.|:..|              ..|...:|::|||....
Zfish   560 KYVHIYHADEDRWESGTALEDRVSGLSACVLLLPRAAMAQAHSWEQRAKASWEEVDWDDSDNSSE 624

  Fly   637 D 637
            |
Zfish   625 D 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	153/538 (28%)
		KELCH repeat	369..416	CDD:276965	15/48 (31%)
		KELCH repeat	420..463	CDD:276965	14/47 (30%)
		KELCH repeat	467..510	CDD:276965	11/42 (26%)
		KELCH repeat	514..558	CDD:276965	16/47 (34%)
		KELCH repeat	561..606	CDD:276965	12/46 (26%)
klhl22	XP_003199199.2	None