DRSC/TRiP Functional Genomics Resources

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Protein Alignment Keap1 and ivns1abp

DIOPT Version :10

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:XP_012816907.1 Gene:ivns1abp / 100145550 XenbaseID:XB-GENE-949332 Length:665 Species:Xenopus tropicalis


Alignment Length:678 Identity:178/678 - (26%)
Similarity:278/678 - (41%) Gaps:150/678 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 CGGRFGSAHSTLDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVL 108
            ||...|:....:.:.....:|..|..|:.||     :..:|..|...||.|:|......||:.||
 Frog    18 CGVAQGTHRKMVPNGSLNFEDEQFIESSVAK-----LNALRKSGQFCDVKLQVCGHEMLAHRAVL 77

  Fly   109 SAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVP 173
            :..||:...:|....:...:|.|:...:.|.|:..:|.:.||.|::.....|..:..||...::.
 Frog    78 ACCSPFLFEIFNSDGESHGISLVRFDDLNPDAVEVLLNYAYTSQLKAETDLVKDVYSAAKKLKID 142

  Fly   174 NVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIA 238
            .|...|..:|..::|..:.|...:|....|...|..|.:.:|:.:..::.::|:||:|....| .
 Frog   143 RVKQVCGDYLLSKIDVQSCISYRNFVNAMGDWRLLSKIDNYIQEHLLEISEQEDFLKLPRLNL-E 206

  Fly   239 LIRRDELNVQEEREVYNAVLKWVK---------------------YDEDNRHCKM----EHI--- 275
            ::..:.:::....::|..|:.||:                     |..|::....    ||.   
 Frog   207 IMLEENVSLPSNGKLYTKVINWVQRSIWENGENLDALLEEVQTLYYSADHKLLDASLLGEHTDAY 271

  Fly   276 -------------------LGAVRCQFLTPNFLKEQMKNCDVLRKVPA----------CREYLAK 311
                               |.:.....|:|..|.:..|:   ..|:.|          |...|..
 Frog   272 EDNIQLIQKKSPRENNHKNLSSSSSGSLSPTALTQSPKH---EWKIIASEKKTNNTYLCLAVLNS 333

  Fly   312 IFKDLTLH--KCP-GVKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDMTWTTLANLRIPRSGLG 373
            :...:.||  ..| .....||..|:.:         ||:|    ..||.....::.:...|||||
 Frog   334 MLCVIFLHGRNSPVNSPSSTPRLTKSL---------SLEI----QPDDSLERVMSPMHYARSGLG 385

  Fly   374 AAFLKGKFYAVGGRNNNIGSSYDSD----WVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYA 434
            .|.|.||..|.||        |:.:    .|:.|...|:.|...|||..||.|..:||:.:.:|.
 Frog   386 TAELNGKLIAAGG--------YNREECLRTVECYDPETDIWTFIAPMKTPRARFQMAVLMDHLYV 442

  Fly   435 VGGSAGMEYH----NTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFD--------- 486
            ||||.|   |    :..|.|||..:.|..|..:.:.|...||..:|..||.:||.|         
 Frog   443 VGGSNG---HSDDLSCGEKYDPKSNVWISVPELRSNRCNAGVCALNGKLYVVGGSDPYGQKGLKN 504

  Fly   487 -----------------------------GNER-----------LASVECYHPENNEWSFLPPLQ 511
                                         ||:.           |.|||||:|||:.|:.:.|:.
 Frog   505 CDVFDPITRMWTCCAQLNIRRHQSAVCELGNKMYIIGGAESWNCLNSVECYNPENDTWTLVAPMN 569

  Fly   512 TGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAI 576
            ..|.|||||.....::||||||||..|:.||.||.|.:.|.|:..:..|||...:..:.:::||.
 Frog   570 VARRGAGVAVYEGKLFVVGGFDGTHALSCVESYDPERNEWKMMGSMTSARSNAGMVAVGDQIYAA 634

  Fly   577 GGFDGNNFLSIVEVYDPRTNTWTTGTPL 604
            ||||||.||:.:|||:|:|..|:..|.|
 Frog   635 GGFDGNEFLNTIEVYNPQTEEWSPFTHL 662

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 PHA03098 92..599 CDD:222983 164/623 (26%)
KELCH repeat 369..416 CDD:276965 18/50 (36%)
KELCH repeat 420..463 CDD:276965 17/46 (37%)
KELCH repeat 467..510 CDD:276965 21/91 (23%)
KELCH repeat 514..558 CDD:276965 22/43 (51%)
KELCH repeat 561..606 CDD:276965 20/44 (45%)
ivns1abpXP_012816907.1 BTB_POZ_NS1BP 41..164 CDD:349615 33/127 (26%)
BACK_NS1BP_IVNS1ABP 156..252 CDD:350577 16/96 (17%)
NanM 376..636 CDD:442289 87/270 (32%)
KELCH repeat 381..424 CDD:276965 18/50 (36%)
KELCH repeat 428..473 CDD:276965 17/47 (36%)
KELCH repeat 476..521 CDD:276965 9/44 (20%)
KELCH repeat 525..568 CDD:276965 12/42 (29%)
KELCH repeat 572..616 CDD:276965 22/43 (51%)
Kelch_1 618..658 CDD:396078 19/39 (49%)
KELCH repeat 619..662 CDD:276965 19/42 (45%)

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