Protein Alignment Keap1 and klhl4

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_001096427.1
• Gene: klhl4 / 100125035
• XenbaseID: XB-GENE-988002
• Length: 719
• Species: Xenopus tropicalis
• Alignment Length: 605
• Identity: 214/605 - (35%)
• Similarity: 330/605 - (54%)
• Gaps: 28/605 - (4%)

  Fly    28 PEEAEMSNTSESCSISCGGRFGSAHSTLDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDV 92
            |||...:.| :...::|        |:.:..:|:..|..|...|:|::..:.|........|.||
 Frog   130 PEEHPEAAT-DRLHVTC--------SSPNRMNASGSDEYFQSLNHAEQTFRKMENYLQQKQLCDV 185

  Fly    93 VLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTE 157
            :|.......|||::||||.|.||.||||..::|::...::::||.|.|:..::::.|||.:.:.|
 Frog   186 LLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKEEEIKIEGVDPDALKALVHYAYTGVLELKE 250

  Fly   158 VTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQV 222
            .|:..||.||.:.|:..|||.||.||.:||.|:|.:||..|.:..|||||.:.|:.:...:|.:|
 Frog   251 DTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGIRSFGDAQGCVELLRVAHSYTMEHFIEV 315

  Fly   223 CQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPN 287
            .:.:|||.|.|.::..|:..|::||.:|..::.|:::|||:|...|...:..:|..:|...|.|.
 Frog   316 IRNQEFLLLPASEIAKLLSSDDINVPDEETIFQALMQWVKHDIQCRQRDLGMLLSYIRLPLLPPQ 380

  Fly   288 FLKEQMKNCDVLRKVPACREYLAKIFK------DLTLHKCPGVKERTPNTTRMIFVAGGF-FRHS 345
            .|.: ::|..:......|:::|.:..|      ..::.:.|..|.| .:|...::..||. ....
 Frog   381 LLAD-LENSPMFANDLECQKFLMEAMKYHLLPERRSMMQSPRTKPR-KSTVGALYAVGGMDATKG 443

  Fly   346 LDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETW 410
            ...:|.|::...:|..::.:...|...|.|.:..|.|.||||:    ....|:.|:.::.||:.|
 Frog   444 ATTIEKYDLRTNSWIQISTMNGRRLQFGVAVIDNKLYVVGGRD----GLKTSNTVECFNPVTKVW 504

  Fly   411 RPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVV 475
            ....|||..||.:||||::..||||||..|..|.||||.:||...:|..|..|...|..|||..:
 Frog   505 SIMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNYVASMSTPRSTVGVAAL 569

  Fly   476 NRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDG------ 534
            |..|||:||.||:..|.|:||:.|..|:||...|:...|.|.|||..|.::|.|||.|.
 Frog   570 NSKLYAVGGRDGSSCLKSMECFDPHTNKWSMCSPMSKRRGGVGVATYNGFLYAVGGHDAPASNHC 634

  Fly   535 TRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWT 599
            :|....|||||.:.|.|.||||:.|.|.|:.::||.::|||:||:||.::|:|||.||.:||.||
 Frog   635 SRLSDCVERYDPKTDNWTMVAPLSIPRDAVGVSPLGDRLYAVGGYDGQSYLNIVESYDAQTNEWT 699

  Fly   600 TGTPLKSGRSGHASAVIYQP 619
            ....|..||:|....||..|
 Frog   700 QDVSLNIGRAGACLEVIKLP 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	191/519 (37%)
		KELCH repeat	369..416	CDD:276965	14/46 (30%)
		KELCH repeat	420..463	CDD:276965	22/42 (52%)
		KELCH repeat	467..510	CDD:276965	20/42 (48%)
		KELCH repeat	514..558	CDD:276965	23/49 (47%)
		KELCH repeat	561..606	CDD:276965	22/44 (50%)
klhl4	NP_001096427.1	BTB_POZ_KLHL4	164..289	CDD:349645	48/124 (39%)
		PHA03098	177..701	CDD:222983	195/529 (37%)
		KELCH repeat	467..510	CDD:276965	14/46 (30%)
		KELCH repeat	514..558	CDD:276965	22/43 (51%)
		KELCH repeat	561..604	CDD:276965	20/42 (48%)
		KELCH repeat	608..657	CDD:276965	22/48 (46%)
		KELCH repeat	661..699	CDD:276965	19/37 (51%)