Protein Alignment CG4009 and Duox1

DIOPT Version :10

• Sequence 1: NP_650588.2
• Gene: CG4009 / 42054
• FlyBaseID: FBgn0038469
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001092767.1
• Gene: Duox1 / 99439
• MGIID: 2139422
• Length: 1551
• Species: Mus musculus
• Alignment Length: 565
• Identity: 161/565 - (28%)
• Similarity: 247/565 - (43%)
• Gaps: 86/565 - (15%)

  Fly    99 DGSCNNLLYPEFGIAVSRYRRLLP---------PRQVEQAPNARLISLSLY----GEQT-RNDRF 149
            ||..|||:...:|...||.:||:|         |.:....||.|.:|..:.    |:.: ||
Mouse    33 DGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLKEPYLPNPRHLSNRVMRGSAGQPSLRN--- 94

  Fly   150 RTMAAMQWGQFVAHDISQLSTQGAPQDCCAEPRHPRCLPINLPRGGPI--AYHTGKTCLHFARSV 212
            ||:..:.:|..|..|:..:.|.|.|.:         .|.|.:|.|.|:  ....|...|.|.||.
Mouse    95 RTVLGVFFGYHVLSDLVSVETPGCPAE---------FLNIYIPHGDPVFDPDKRGNVVLPFQRSR 150

  Fly   213 SDADAICPKVEEPQPEKLTVATAYLDLSSIYGNNPSQNRKVRLFKGGLLKT---------SYTNG 268
            .|.:. ......|:.:...| |.:||.|:|||::.|.:..:|.|.||.|.:         |.::.
Mouse   151 WDRNT-GQSPSNPRDQSNQV-TGWLDGSAIYGSSHSWSDTLRSFSGGQLASGPDPAFPSDSQSSL 213

  Fly   269 QHWLPVSQNENGECGAKSECYIVPDIRNRFSPTIALLQTLLVREHNRLAENLALINPDHSDERIF 333
            ..|: ......|:.|.:. .|.....|....|.:..|..|..|.||..|..||..:|...||.:|
Mouse   214 LMWM-APDPSTGQGGPRG-VYAFGAQRGNREPFLQALGLLWFRYHNLCARKLAQEHPHWGDEELF 276

  Fly   334 QEARKINIAQFQKITYYDWLPLFVGRTYTYLNGLIYPVEPTEYVNDYDETVNPAAYAEFSAAAFR 398
            |.|||..||.:|.|..|:|||.|:.:|            |.||.. |...::|:...||..|:.:
Mouse   277 QHARKRVIATYQNIAMYEWLPSFLKQT------------PPEYPG-YRPFLDPSISPEFVVASEQ 328

  Fly   399 YAHTQIPG----------WFSLVAPNRRSNRTMRLSDFLDRTETIRLLDTSDNFDALLRGLATQL 453
            :..|.:|.          :..:.:.|...:..:|:.:.....|..: |..:::.||||.|:|:|:
Mouse   329 FLSTMVPSGVYMRNASCHFQGIPSHNSSVSGALRVCNSYWSREHPK-LQRAEDVDALLLGMASQI 392

  Fly   454 HKRSDGNIDREIKHY------FNRKEFEEYGSDLKSIDIQRARDFGLASYNDVREFCGLRRAVDW 512
            .:|.|..:..:::.:      |:|.::      |.|. :||.||.||.||...||..||.....|
Mouse   393 AEREDHVVVEDMQDFWPGPLKFSRTDY------LASC-LQRGRDLGLPSYTKAREALGLSPISHW 450

  Fly   513 ADFAHEIPGEKISLLRRLYATPDD----VELGVGGTLEYHVPDALFGPTLLCVIGKQFLNTRRGD 573
            .|....:.....::|....|..:.    :||..||.||.|...   ||....::..||:..|.||
Mouse   451 QDINPALSRSNGTVLEATAALYNQDLSRLELLPGGLLESHGDP---GPLFSTIVLDQFVRLRDGD 512

  Fly   574 RFFFERENEGGFSRAQLAEIRKVSLSSLFCSNANY-LHLIQPNVF 617
            |::||....|.||:.::||||..||..:..:..|. ...:|||||
Mouse   513 RYWFENTRNGLFSKEEIAEIRNTSLRDILVAVTNVDPSALQPNVF 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4009	NP_650588.2	An_peroxidase	95..617	CDD:460804	159/563 (28%)
Duox1	NP_001092767.1	dual_peroxidase_like	32..591	CDD:188652	161/565 (28%)
		EFh	820..881	CDD:238008
		EFh	857..915	CDD:238008
		PLN02292	1089..>1412	CDD:215165
		NOX_Duox_like_FAD_NADP	1277..1551	CDD:99783