DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment modSP and Masp2

DIOPT Version :10

Sequence 1:NP_536776.2 Gene:modSP / 42032 FlyBaseID:FBgn0051217 Length:628 Species:Drosophila melanogaster
Sequence 2:NP_742040.1 Gene:Masp2 / 64459 RGDID:620214 Length:685 Species:Rattus norvegicus


Alignment Length:648 Identity:137/648 - (21%)
Similarity:209/648 - (32%) Gaps:187/648 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 KPY--FQCTYGACVIGTAGCNGVNECADGSDETRLRCGNEDDIRQHDRRLQG----NCK------ 124
            ||:  |:..|               .|:..||.|...|:......:.....|    :|:      
  Rat   125 KPFTGFEAFY---------------AAEDVDECRTSLGDSVPCDHYCHNYLGGYYCSCRVGYILH 174

  Fly   125 ENEFKCPSGIC-----LDKSNFLCDGK--------DDCADGTGFDE------------SVELCGH 164
            :|:..| |.:|     ..:|.||...:        ..||.....:|            .||:...
  Rat   175 QNKHTC-SALCSGQVFTGRSGFLSSPEYPQPYPKLSSCAYNIRLEEGFSITLDFVESFDVEMHPE 238

  Fly   165 MECPAYSFKCGTGGCISGSLSCNGENDCYDGSDEAPLLCNTTKKVTTPVVTETPLELLG------ 223
            .:||..|.|..|.         ..|...:.|....|.:...:.|||....|:......|      
  Rat   239 AQCPYDSLKIQTD---------KREYGPFCGKTLPPRIETDSNKVTITFTTDESGNHTGWKIHYT 294

  Fly   224 -----CPLPLGDERPILTGDGSRVLTGPITRGTVRFSCKQGY-VLEGEE-----SSYCAKNKWST 277
                 ||.|....    .|..|.|....:.:.:....||.|: :|:|..     ::.|.|:....
  Rat   295 STAQPCPDPTAPP----NGHISPVQATYVLKDSFSVFCKTGFELLQGSVPLKSFTAVCQKDGSWD 355

  Fly   278 STIPKCVKYCSTAGEFDGYSTKALCTHNGQQVECRKPFHPPGTEVKFV---------------CS 327
            ..||:|                       ..::|..|...|...|.::               |.
  Rat   356 RPIPEC-----------------------SIIDCGPPDDLPNGHVDYITGPEVTTYKAVIQYSCE 397

  Fly   328 TGFKTLSPLPEMRCMKGGYW--NRGRQR---CEQDCGQLATPIKQFSSGGYTINNTVV-----PW 382
            ..|.|:|...:..|...|:|  ::|.:.   |:..||     :...:|||..|.....     ||
  Rat   398 ETFYTMSSNGKYVCEADGFWTSSKGEKSLPVCKPVCG-----LSTHTSGGRIIGGQPAKPGDFPW 457

  Fly   383 HVGLYVWHNEKDYHFQCGGSLLTPDLVITAAHCVYDEGTRLPYSYDTFRVIAAKFYRNYGETTPE 447
            .|.|.       ......|:|:..|.|:||||.||.: |....|.|....|..:...:|.:..||
  Rat   458 QVLLL-------GETTAAGALIHDDWVLTAAHAVYGK-TEAMSSLDIRMGILKRLSPHYTQAWPE 514

  Fly   448 EKRRDVRLIEIAPGYKGRTENYYQDLALLTLDEPFELSHVIRPICVTFASFAEKESVT---DDVQ 509
                   .:.|..||. ....:..|:||:.|.....::..|.|||:     ..||:.:   .|..
  Rat   515 -------AVFIHEGYT-HGAGFDNDIALIKLKNKVTINRNIMPICL-----PRKEAASLMKTDFV 566

  Fly   510 GKFAGWNIENK----HELQFV--PAVSKSNSVCRRNLRDIQADKFCI------FTQGKSLACQGD 562
            |..|||.:..|    ..|.||  |.|...........:.....|..:      ...|...:|:||
  Rat   567 GTVAGWGLTQKGFLARNLMFVDIPIVDHQKCATAYTKQPYPGAKVTVNMLCAGLDAGGKDSCRGD 631

  Fly   563 SGGGFTSELPTNAFSTWNTARHFLFGVIS----NAPNADQCAHSLTVMTNIQHFEDMILNAMN 621
            |||..       .|....|.|.|:.|::|    |...::|..    |.|.:.::...|.|.:|
  Rat   632 SGGAL-------VFLDNETQRWFVGGIVSWGSINCGGSEQYG----VYTKVTNYIPWIENIIN 683

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
modSPNP_536776.2 LDLa 27..58 CDD:197566
LDLa 70..101 CDD:197566 5/30 (17%)
LDLa 123..157 CDD:197566 10/52 (19%)
LDLa 167..199 CDD:238060 7/31 (23%)
CCP <251..284 CDD:153056 9/38 (24%)
Tryp_SPc 371..616 CDD:214473 66/268 (25%)
Masp2NP_742040.1 CUB 19..136 CDD:238001 4/25 (16%)
FXa_inhibition 152..180 CDD:464251 3/27 (11%)
CUB 184..295 CDD:238001 22/119 (18%)
Sushi 300..361 CDD:459664 15/64 (23%)
Sushi 366..429 CDD:459664 12/62 (19%)
Tryp_SPc 444..681 CDD:238113 65/268 (24%)
Blue background indicates that the domain is not in the aligned region.

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