DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gyc89Db and Gucy2d

DIOPT Version :10

Sequence 1:NP_650551.1 Gene:Gyc89Db / 42002 FlyBaseID:FBgn0038436 Length:669 Species:Drosophila melanogaster
Sequence 2:NP_077356.1 Gene:Gucy2d / 79222 RGDID:620438 Length:1108 Species:Rattus norvegicus


Alignment Length:686 Identity:172/686 - (25%)
Similarity:283/686 - (41%) Gaps:182/686 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 GRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPKMKSPSMQLTNMDDDGAVILYR 134
            |..||.|....    ::..||.:...:|:. ..:|:||      :..|:..:..::|  ...|:.
  Rat   467 GLVFVGFLLVI----VVGLTGAFLAHYLRH-RLLHMQM------VSGPNKIILTLED--VTFLHP 518

  Fly   135 SGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGP-----IKLTEGPLTVIVKYRL 194
            .|         |...:||:.    ..::....|.:||....:.|     |.|.||....:.|   
  Rat   519 QG---------GSSRKVAQG----SRSSLATRSTSDIRSVPSQPQESTNIGLYEGDWVWLKK--- 567

  Fly   195 DFDNRDYMAKR-VNVIAHPSQLKMPSVDLNVFLELF-------PFT-------IVLDH----DMK 240
             |....:||.| ...:|.....::...::.::|.||       |.|       :|.:|    .:.
  Rat   568 -FPGEHHMAIRPATKMAFSKLRELRHENVALYLGLFLAGTADSPATPGEGILAVVSEHCARGSLH 631

  Fly   241 ITLAGEKIVETWI---------------LHNPGVNPKTFIGSHILERFKCRRPKDTQIQWETILQ 290
            ..||...|...|:               ||:.||       :|  .|.|.|         ..::.
  Rat   632 DLLAQRDIKLDWMFKSSLLLDLIKGMRYLHHRGV-------AH--GRLKSR---------NCVVD 678

  Fly   291 MRTVLFEFELIRTGHNRAAYDAALNFDFENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAAT 355
            .|.||   ::...||.|                   |.|||.:                .....:
  Rat   679 GRFVL---KVTDHGHGR-------------------LLEAQRV----------------LPEPPS 705

  Fly   356 SKDEI--------DPATGQRRHSVG--------LRSILLKGQMF---------YIKDVDSLIFLC 395
            ::|::        |||..:|....|        ::.::.:...:         .|:.|.|...||
  Rat   706 AEDQLWTAPELLRDPALERRGTLAGDVFSLGIIMQEVVCRSTPYAMLELTPEEVIQRVRSPPPLC 770

  Fly   396 SPLIENLDE--LHGIGLYLN------DLNPHGLSRELVMAGWQHCSK------LEIMFEKEEQRS 446
            .||: ::|:  :..|.|...      :|.|   |.:|....::..:|      ::.|....||.|
  Rat   771 RPLV-SMDQAPMECIQLMAQCWAEHPELRP---SMDLTFDLFKGINKGRKTNIIDSMLRMLEQYS 831

  Fly   447 DELE----KSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDSG 507
            ..||    :..|..:..|::.|.||..|:|..:||.::.......:.||||::.|.:::..  :.
  Rat   832 SNLEDLIRERTEELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVGF--TT 894

  Fly   508 SNNIQDAMQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVN-PLHAEHACDLALRV 571
            .:.:.:.::.|..||.:::..|..|.|..||||||:|..||..||.|..| ..||....:::|.:
  Rat   895 ISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDI 959

  Fly   572 MKKV---KAHALP--GVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMI--Q 629
            :..|   :...:|  .|.||:|::|||.||||||:.:||||||||||||||||||:..|:.|  .
  Rat   960 LSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVN 1024

  Fly   630 LSNYTALKVQKVGYKVEARGFVKVKGKGEMETYWLL 665
            :|....|:....|:::|.||..::||||..:||||:
  Rat  1025 MSTVRILRALDQGFQMECRGRTELKGKGVEDTYWLV 1060

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc89DbNP_650551.1 HNOB 2..161 CDD:462233 17/90 (19%)
HNOBA 218..479 CDD:462234 65/336 (19%)
Nucleotidyl_cyc_III 488..665 CDD:448371 75/184 (41%)
Gucy2dNP_077356.1 PBP1_sensory_GC_DEF-like 58..434 CDD:380594
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 520..552 8/44 (18%)
PK_GC-2D 540..814 CDD:270945 62/337 (18%)
HNOBA <823..868 CDD:462234 15/44 (34%)
CYCc 848..1039 CDD:214485 73/192 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1069..1108
Blue background indicates that the domain is not in the aligned region.

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