Protein Alignment Gyc89Db and Gucy1b1

DIOPT Version :10

• Sequence 1: NP_650551.1
• Gene: Gyc89Db / 42002
• FlyBaseID: FBgn0038436
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_059497.1
• Gene: Gucy1b1 / 54195
• MGIID: 1860604
• Length: 620
• Species: Mus musculus
• Alignment Length: 691
• Identity: 199/691 - (28%)
• Similarity: 319/691 - (46%)
• Gaps: 113/691 - (16%)

  Fly     1 MYGMLYESVQHYIQQEYGMETW---RKVCQIVDCKHQSFKTHQIYPDKLMPDFAAA----LSAST 58
            |||.:..:::..:.:.||.|.|   :|..|:.:  ...|....||.|....|..||    |:.:.
Mouse     1 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDE--EGQFLVRIIYDDSKTYDLVAAASKVLNLNA 63

  Fly    59 GESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPKMKSPSMQLTN 123
            ||    .:..||:.|..|....|||.::|..|....:|||::|.:|..:...||.|::||.:.|:
Mouse    64 GE----ILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTD 124

  Fly   124 MD-DDGAVILYRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLTEGPLT 187
            .: ..|.::.|.|.|.|:...:||.:..||::.:|.::...|::.:|:.|..|...|:..|....
Mouse   125 AEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFLIEEKESKEE 189

  Fly   188 VIVKYRLDFDNRDYMAKRVNVIAHPSQLKMPSVDLNVFLELFPFTIVLDHDMKITLAGEKIVETW 252
            ...:....|:.......|::..              .|.:.|||.|:.|.::.:|..|..|....
Mouse   190 DFYEDLDRFEENGTQESRISPY--------------TFCKAFPFHIIFDRNLVVTQCGNAIYRVL 240

  Fly   253 ILHNPGVNPKTFIGSHILERFKCRRPKDTQIQWETILQMRTVLFEFELIRTGHNRAAYDAALNFD 317
            ....||               .|                 ::|..|.|:|. |        ::..
Mouse   241 PQLQPG---------------NC-----------------SLLSVFSLVRP-H--------IDIS 264

  Fly   318 FENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQRRHSVGLRSILLKGQM 382
            |...     |:....:.:..:||...:..|.|.      :||:   ||..     :..:.|||||
Mouse   265 FHGI-----LSHINTVFVLRSKEGLLDVEKLEC------EDEL---TGAE-----ISCLRLKGQM 310

  Fly   383 FYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQH------CSKLEIMFEK 441
            .|:.:.||::|||||.:.|||:|...||||:|:..|..:|:||:.|.|.      ..:|||:
Mouse   311 IYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEIL--- 372

  Fly   442 EEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVM--NIY 504
                :|.|:.:|...:..|::.|.||||::|..:|..:|.......:.::.|:::|..::  |.:
Mouse   373 ----TDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAF 433

  Fly   505 DSGSNNIQDAMQAVTTLNKV---FSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACD 566
            .|...:.:.||:.|..||.:   |..|.:...:||||||||||..||.|||.|:....||...|.
Mouse   434 CSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICH 498

  Fly   567 LALRVMKKVKAHALPG--VAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQ 629
            |||.:|:......:.|  |.|.:||::|.||.||:|.::|||||||:|||..||.|::.:...|.
Mouse   499 LALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKIN 563

  Fly   630 LSNYTALKVQKVG-----YKVEARGFVKVKGKGEMETYWLL 665
            :|.||...:....     :.:|.||.|.:|||.|....|.|
Mouse   564 VSEYTYRCLMSPENSDPLFHLEHRGPVSMKGKKEPMQVWFL 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:462233	48/166 (29%)
		HNOBA	218..479	CDD:462234	69/266 (26%)
		Nucleotidyl_cyc_III	488..665	CDD:448371	71/188 (38%)
Gucy1b1	NP_059497.1	HNOB	2..166	CDD:462233	48/169 (28%)
		HNOBA	207..406	CDD:462234	70/279 (25%)
		Guanylate_cyc	412..605	CDD:425528	72/193 (37%)