Protein Alignment Gyc89Db and Gucy2c

DIOPT Version :10

• Sequence 1: NP_650551.1
• Gene: Gyc89Db / 42002
• FlyBaseID: FBgn0038436
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_037302.1
• Gene: Gucy2c / 25711
• RGDID: 2771
• Length: 1072
• Species: Rattus norvegicus
• Alignment Length: 792
• Identity: 180/792 - (22%)
• Similarity: 293/792 - (36%)
• Gaps: 230/792 - (29%)

  Fly    36 FKTHQIYPDKLMPD--------------FAAALSAS---TGESFDFCMNFFGRCFVRFFSNFGYD 83
            |..|....|...|:              |.|..|.|   ..|..||.:.:.....:     ||:
  Rat   275 FSNHYFEDDTRAPEYMDNVLVLTLPPEKFIANASVSGRFPSERSDFSLAYLEGTLL-----FGH- 333

  Fly    84 KMIRSTGRYFCDFLQSIDNIHVQMRFTYPKMKSPSMQLT--------NMDDDGAV-----ILYRS 135
             |:::       ||::.:::      |.||.......||        .:||.|.:     :||.|
  Rat   334 -MLQT-------FLENGESV------TTPKFARAFRNLTFQGLEGPVTLDDSGDIDNIMCLLYVS 384

  Fly   136 GRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQ---NDICGGTAGP--------------IKLTE 183
            ..|...|.|:...|...:.........::.::.   ||:.|  .||              :.|..
  Rat   385 LDTRKYKVLMAYDTHKNQTIPVATSPNFIWKNHRLPNDVPG--LGPQILMIAVFTLTGIVVVLLL 447

  Fly   184 GPLTVIVKYRLDFDNRDYMAKRVNVIAHPSQLKMPSVDLNVFLELFPFTIVLDHD---------- 238
            ..|.|:.|||.|.:.|......:     ||:...| ::.|   |....::.:|.|
  Rat   448 IALLVLRKYRRDHELRQKKWSHI-----PSENIFP-LETN---ETNHVSLKIDDDRRRDTIQRVR 503

  Fly   239 ------MKITLAG-----------EKIVETWILHNPGVNPKTFIGS-----------HILERFKC 275
                  .|:.|..           :||....:|.:...|...|.|:           ...||...
  Rat   504 QCKYDKKKVILKDLKHCDGNFSEKQKIELNKLLQSDYYNLTKFYGTVKLDTRIFGVVEYCERGSL 568

  Fly   276 RR--------PKDTQIQWETILQMRTVLFEFELIRTGHNRAAYDAALNFDF------ENFDEASS 326
            |.        |..|.:.||         |:..::.        |.|....:      |......|
  Rat   569 REVLNDTISYPDGTFMDWE---------FKISVLN--------DIAKGMSYLHSSKIEVHGRLKS 616

  Fly   327 LN-EAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQRR-----HSVGLRSILLKGQMFY- 384
            .| ...:..:....:|...:.........|:.:.:..||..::     .|:..:.|:|:.:.||
  Rat   617 TNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQATISQKGDVYSFSIIAQEIILRKETFYT 681

  Fly   385 --IKDVDSLIFLCSP-----------LIENLDELHGIGLYLNDLNPHGLSRELVMAGWQH----- 431
              .:|.:..||....           .:|..||.. :.:||           ||.:.|:.
  Rat   682 LSCRDQNEKIFRVENSYGTKPFRPDLFLETADEKE-LEVYL-----------LVKSCWEEDPEKR 734

  Fly   432 ---------CSKLEIMF--EKEEQRSDEL---------------EKSLELADSWKRQGDELLYSM 470
                     .:|:..:|  :|.|...|.|               |:..:|..:.:.:.|.|.:.:
  Rat   735 PDFKKIESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFML 799

  Fly   471 IPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDSGSNNI---QDAMQAVTTLNKVFSALDEEI 532
            :||.:.:.:::......:.:|||::.|.:::     |...|   ...|:.|..||.::.:.|:.:
  Rat   800 LPRLVVKSLKEKGIVEPELYEEVTIYFSDIV-----GFTTICKYSTPMEVVDMLNDIYKSFDQIV 859

  Fly   533 ISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLA------LRVMKKVKAHALPG--VAIRVGI 589
            ....||||||:|..|:..||.|..|  ...||.|::      |..|...:...|||  |.||:|:
  Rat   860 DHHDVYKVETIGDAYVVASGLPMRN--GNRHAVDISKMALDILSFMGTFELEHLPGLPVWIRIGV 922

  Fly   590 NSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQKVG--YKVEARGFVK 652
            :|||..|||||:|:||||||||||||||||||:..|..|.:|:.|...:::..  :..|.||...
  Rat   923 HSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTIAILRRTDCQFLYEVRGETY 987

  Fly   653 VKGKGEMETYWL 664
            :||:|...||||
  Rat   988 LKGRGTETTYWL 999

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:462233	31/154 (20%)
		HNOBA	218..479	CDD:462234	58/363 (16%)
		Nucleotidyl_cyc_III	488..665	CDD:448371	76/190 (40%)
Gucy2c	NP_037302.1	Periplasmic_Binding_Protein_type1	34..414	CDD:471960	31/158 (20%)
		Protein Kinases, catalytic domain	479..749	CDD:473864	46/301 (15%)
		CYCc	787..978	CDD:214485	70/197 (36%)