Protein Alignment Gyc89Db and Gucy1b2

DIOPT Version :10

• Sequence 1: NP_650551.1
• Gene: Gyc89Db / 42002
• FlyBaseID: FBgn0038436
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: XP_063130063.1
• Gene: Gucy1b2 / 25206
• RGDID: 2770
• Length: 751
• Species: Rattus norvegicus
• Alignment Length: 729
• Identity: 197/729 - (27%)
• Similarity: 338/729 - (46%)
• Gaps: 150/729 - (20%)

  Fly     1 MYGMLYESVQHYIQQEYGMETWRKV---CQIVDCKHQSFKTHQIYPD----KLMPDFAAALSAST 58
            :||.:...:|..:.:::|.|||.|:   .::.|.    |.|:.:|.|    ||:.:....|..
  Rat    10 LYGFINTCLQSLVTEKFGEETWEKLKASAEVQDV----FMTYTVYDDIITIKLIQEACKVLDV-- 68

  Fly    59 GESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPKMKSPSMQLTN 123
              |.:..:..||..|.:|....|||:|:|:.|....:|::::|.:|..:..:|.:|.:||.::..
  Rat    69 --SMEAILKLFGEYFFKFCKMSGYDRMLRTLGGNLTEFIENLDALHSYLALSYQEMNAPSFRVEE 131

  Fly   124 MDDDGAVIL-YRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLE--------------------- 166
             ..|||::| |.|.|.|:...:.|.:..|||:|:..|:...:|:
  Rat   132 -GADGAMLLHYYSDRHGLCHIVPGIIEAVAKDFFDTDVAMSILDMNEEVERTGKKEHVVFLVVQK 195

  Fly   167 SQNDICGGTAGPIKLTE----------GPLTVIVKYRLDF-----DNRDYMAKRVNVI------- 209
            :...|.|..|...:.:|          |.|..:.:..|:.     :.....|.|.:|:
  Rat   196 AHRQIRGAKASRPQGSEDSQADQEALQGTLLRMKERYLNIPVCPGEKSHSTAVRASVLFGKGPLR 260

  Fly   210 -----AHPSQLKMPSVDLNVFLELFPFTIVLDHDMKITLAGEKIVETWILHNPGVNPKTFIGSHI 269
                 .:|.:|   .|:..||.:.|||.||.|..:::..||..|.:    :.||:..:.|    .
  Rat   261 DTFQPVYPERL---WVEEEVFCDAFPFHIVFDEALRVKQAGVNIQK----YVPGILTQKF----A 314

  Fly   270 LERFKCRRPKDTQIQWETILQMRTVLFEFELIRTGHNRAAYDAALNFDFENFDEASSLNEAQAMA 334
            |:.:                        |.:|   |.:..::.:....|.|
  Rat   315 LDEY------------------------FSII---HPQVTFNISSICKFIN-------------- 338

  Fly   335 LASAKEFSAENAKEEAAAAATSKDEIDPATGQRRHSVGLRSILLKGQMFYIKDVDSLIFLCSPLI 399
                .:|..:..||....|..|:.                .:.|:|||.:::.:..:||:|||.:
  Rat   339 ----SQFVLKTRKEMMPKARKSQP----------------MLKLRGQMIWMESLRCMIFMCSPKL 383

  Fly   400 ENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLELADSWKRQGD 464
            .:|.||....::|:|:.||..:|:|::...|..:::|:..:.|:::.:....|..||.. |::.:
  Rat   384 RSLQELEESKMHLSDIAPHDTTRDLILLNQQRLAEMELSCQLEKKKEELRVLSNHLAIE-KKKTE 447

  Fly   465 ELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDSGSNNIQDA---MQAVTTLNKVFS 526
            .|||:|:|..:|.::::..:.....||..:::|.:|:..     .||..|   :|.|..||.::|
  Rat   448 TLLYAMLPEHVANQLKEGRKVAAGEFETCTILFSDVVTF-----TNICAACEPIQIVNMLNSMYS 507

  Fly   527 ALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLAL--RVMKKVKAHALPG--VAIRV 587
            ..|.......||||||:|..||.|.|.|.....||:...:.||  |:..|...:.:.|  :.|||
  Rat   508 KFDRLTSVHDVYKVETIGDAYMVVGGVPVPVESHAQRVANFALGMRISAKEVMNPVTGEPIQIRV 572

  Fly   588 GINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQKVGYKVEARGFVK 652
            ||::|||:|||||.|:||||||||||||||||||...|..:.||......::..|:::..||.::
  Rat   573 GIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPSKVHLSPTAHRALKNKGFEIVRRGEIE 637

  Fly   653 VKGKGEMETYWLLE 666
            |||||:|.||:|::
  Rat   638 VKGKGKMTTYFLIQ 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:462233	48/166 (29%)
		HNOBA	218..479	CDD:462234	57/260 (22%)
		Nucleotidyl_cyc_III	488..665	CDD:448371	78/183 (43%)
Gucy1b2	XP_063130063.1	None