Protein Alignment Gyc89Db and Gucy1a2

DIOPT Version :10

• Sequence 1: NP_650551.1
• Gene: Gyc89Db / 42002
• FlyBaseID: FBgn0038436
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_001028494.1
• Gene: Gucy1a2 / 234889
• MGIID: 2660877
• Length: 730
• Species: Mus musculus
• Alignment Length: 659
• Identity: 157/659 - (23%)
• Similarity: 296/659 - (44%)
• Gaps: 126/659 - (19%)

  Fly     5 LYESVQHYIQQEYGMETWRKVCQIVDCKHQSFKTHQIYPDKLMPDFAAALSAST---GESFDFCM 66
            |..::|:|..|..|.....|....:. |..|:..|....:  :.|.:..|..:.   |..|....
Mouse   107 LKRTLQYYEHQVIGYRDAEKNFHNIS-KRCSYADHSNKEE--IEDVSGILQCTANVLGLQFQEIQ 168

  Fly    67 NFFGRCFVR--FFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPK---MKSPSMQLTNMDD 126
            ..||..|.:  |..|   ::::|:.|....||....|.:...:|.::.|   ::|.|.....:.:
Mouse   169 ERFGEEFFKICFDEN---ERVLRAVGSTLQDFFNGFDALLEHIRTSFGKQATLESSSFLCKELPE 230

  Fly   127 DGAVILYRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLTEGPLTVIVK 191
            ...::.|......:...::|.:....|..|.|::....:|::. :|...:.|...:  .||.::|
Mouse   231 GTLMLHYFHPHHTVGFAMLGMIKAAGKRIYHLNVEVEQIENEK-LCFDGSNPSNCS--CLTFLIK 292

  Fly   192 ----YRLDFDNRDYMAKRVNVIAHPSQLKMPSVDLNVFLELFPFTIVLDHDMKITLAGEKIVETW 252
                .::..||....::      .|:.|:   :.:|.|...|||.::.|.:|.:...||.:.:
Mouse   293 ECETTQITKDNPQGTSQ------VPADLR---ISINTFCRAFPFHLMFDSNMVVLQLGEGLRK-- 346

  Fly   253 ILHNPGVNPKTFIGSHILERFKCRRPKDTQIQWETILQMRTVLFE--FELIRTGHNRAAYDAALN 315
                                         |::::|   .|.:.||  ||::....| |.:|..|
Mouse   347 -----------------------------QLRYDT---HRALKFEDCFEIVSPMIN-ATFDRVL- 377

  Fly   316 FDFENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQRRHSVGLRSILLKG 380
                               |..:..|......|  |:...::|::               :.:||
Mouse   378 -------------------LRLSTPFVIRTKPE--ASGTENEDKV---------------MEIKG 406

  Fly   381 QMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQR 445
            ||.::.:..:::||.||.::.||||.|.||:|:|:..|..:|::::.|.|  :|.:...:|   |
Mouse   407 QMIHVPESSAILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQ--AKAQDGLKK---R 466

  Fly   446 SDELEKSLE----LADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDS 506
            .|:|:.:||    ..:..|::..:||||:.|..:|:::.:.::...:.|::|:::|.:::
Mouse   467 MDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIV----- 526

  Fly   507 GSNNI---QDAMQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLA 568
            |...|   ...||.::.||::::..|.:.....:|||||:|..|...||....:..||:....:|
Mouse   527 GFTAICAQCTPMQVISMLNELYTRFDHQCGLLDIYKVETIGDAYCVASGLHRKSLCHAKPIALMA 591

  Fly   569 LRVMKKVKAHALP---GVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQL 630
            |::|:..:....|   .:.:|:||:||.|:|||||:::|||||||:.|..||:.||.|.|..|.:
Mouse   592 LKMMELSEEVLTPDGKAIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINV 656

  Fly   631 S--NYTALK 637
            |  .|..||
Mouse   657 SPTTYQLLK 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:462233	32/163 (20%)
		HNOBA	218..479	CDD:462234	60/266 (23%)
		Nucleotidyl_cyc_III	488..665	CDD:448371	55/158 (35%)
Gucy1a2	NP_001028494.1	HNOB	<157..268	CDD:462233	21/113 (19%)
		HNOBA	314..501	CDD:462234	60/266 (23%)
		Guanylate_cyc	512..696	CDD:425528	55/159 (35%)