Protein Alignment Gyc89Db and gcy-37

DIOPT Version :10

• Sequence 1: NP_650551.1
• Gene: Gyc89Db / 42002
• FlyBaseID: FBgn0038436
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_500171.2
• Gene: gcy-37 / 191658
• WormBaseID: WBGene00001557
• Length: 708
• Species: Caenorhabditis elegans
• Alignment Length: 695
• Identity: 158/695 - (22%)
• Similarity: 297/695 - (42%)
• Gaps: 118/695 - (16%)

  Fly     1 MYGMLYESVQHYIQQEYGMETWRKVCQ----------IVDCKHQSFKTHQIYPDKLMPDFAAALS 55
            |.|..:..|...|.::||.|...::.:          .:.|.:...:|.:|:         ...:
 Worm     1 MIGWTHVCVSALILRKYGPEVLEEILRKAGYQEDIKFDIQCYYDDTETMRIF---------RVAA 56

  Fly    56 ASTGESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHV---QMRFTYPKMKSP 117
            ...|.|.|.....:|...:......|:.||:........:||.:::::|.   |:.|. .:||.|
 Worm    57 TVLGLSVDDMWEMYGEFLITHACETGWQKMLFCMANNLQEFLDNLNSMHYFIDQIAFK-SEMKGP 120

  Fly   118 SMQLTNMDDDGAVILYRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLT 182
            :.|.....:.|..:.|.|.|.|:...:.|.:.:.|:..:.:|:...:||...:         :..
 Worm   121 TFQCEPFGESGLKLHYFSFRQGLFPIVKGLVRKTARTLFEMDVKVCMLERNQE---------RRK 176

  Fly   183 EGPLTVIVKYRLDFDNRDYMAKRV-------NVIAHPSQLKMPS---VDLNVFLELFPFTIVLDH 237
            .|.:..:: :.::.|:.....||:       ....:.....:.|   |.|..|..:||:.:..:.
 Worm   177 SGMVEHVI-FSVEPDDNHRKGKRLFHKFRNTKTTENAPSFTLSSTILVGLRDFKNIFPYHVCFNK 240

  Fly   238 DMKITLAGEKIVETWILHNPGV-NPKTFIGSHILERFKCRRPKDTQIQWETILQMRTVLFEFELI 301
            .|.|...|     .::|...|: |.||...|.:::..   :|.|.|:.::.:|.....||.|:|
 Worm   241 QMIIEHIG-----IYLLREYGLENKKTLKVSDLMQLV---QPSDIQLTYKNVLSYLNTLFIFQL- 296

  Fly   302 RTGHNRAAYDAALNFDFENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQ 366
                                                 |..|..|..:|.::.|..
 Worm   297 -------------------------------------KHHSKRNEVQEGSSEAFQ---------- 314

  Fly   367 RRHSVGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQH 431
                   :.::|||:|..|.|.:|:||:|||.:..:.::..:.||::|:..|..:|:|||.....
 Worm   315 -------QPLVLKGEMMPINDGNSIIFICSPHVTTVRDILNLKLYISDMPMHDATRDLVMLNQSR 372

  Fly   432 CSKLEIMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVI 496
            ..::|:. :|.|:...:::|..|..:..|.|.|.||:..:|..|||.:|.::....|.|.:.|||
 Worm   373 ICQMELN-KKLEETMKKMKKMTEELEVKKSQTDRLLFEFVPPVIAEALRAAKTVPAQEFSDCSVI 436

  Fly   497 FIEVMNIYDSGSNNIQDAMQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHA 561
            |.::.:.:....|  ....:.:|.:..:|...|..|.....|||.::...|:.|.|.|:.|..|.
 Worm   437 FTDIPDFFTISVN--CSPTEIITVVTDLFHRFDRIIEKHKGYKVLSLMDSYLIVGGVPNANQYHC 499

  Fly   562 EHACDLALRVMKKVKAHALP----GVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESS 622
            |.:.:|||.::.:.|...:|    .|.:|:|::.||||||:|..:.||:|:.|:|||....:.|.
 Worm   500 EDSLNLALGLLFEAKQVVVPKLERSVRLRIGVHCGPVVAGIVSQQKPRFCVLGNTVNVTKSICSH 564

  Fly   623 SDPWMIQLSNYTALKVQ---KVGYKVEARGFVKVKGKGEMETYWL 664
            |.|..:.:||.....|.   |..:...|.|::::: .|::.|::|
 Worm   565 SSPGKVLVSNAVRTMVTKHLKSIFVFNANGYLELQ-SGKVLTHFL 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:462233	33/171 (19%)
		HNOBA	218..479	CDD:462234	62/264 (23%)
		Nucleotidyl_cyc_III	488..665	CDD:448371	55/184 (30%)
gcy-37	NP_500171.2	HNOB	3..165	CDD:462233	33/171 (19%)
		HNOBA	223..419	CDD:462234	61/259 (24%)
		CYCc	400..577	CDD:214485	58/178 (33%)