Protein Alignment Gyc89Db and gcy-36

DIOPT Version :10

• Sequence 1: NP_650551.1
• Gene: Gyc89Db / 42002
• FlyBaseID: FBgn0038436
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_510557.3
• Gene: gcy-36 / 191657
• WormBaseID: WBGene00001556
• Length: 675
• Species: Caenorhabditis elegans
• Alignment Length: 696
• Identity: 197/696 - (28%)
• Similarity: 324/696 - (46%)
• Gaps: 103/696 - (14%)

  Fly     1 MYGMLYESVQHYIQQEYGMETWRKVCQIV--DCKHQSFKTHQIYPDKLMPDFAAALSASTGESFD 63
            |:|.::||::..:.:.||...|.||.:..  :...::...| .|.|........|:|.....:.:
 Worm     1 MFGFIHESIRQLMIRTYGEAFWSKVLERAGFEAGKENIINH-YYSDADTFSLVDAVSVILKVTRE 64

  Fly    64 FCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPK--MKSPSMQLTNMDD 126
            .....:|...:::....|:|.:|||.......||.::|::|..:.....|  ::.||.:..:..|
 Worm    65 QVWEMYGCFLIQYTMETGWDDLIRSMSPNLKGFLDNLDSLHYFIDHVVYKANLRGPSFRCEDNPD 129

  Fly   127 DGAVILYRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLTEGP-----L 186
            ....:.|.:||.|:...:.|.:.|.||..:.||::.       .|.|.|...:::..|.     :
 Worm   130 GTITLHYYTGRPGLYPIVKGVLREAAKRVFKLDVSM-------TITGRTQRSVQMATGERIEEHV 187

  Fly   187 TVIVKYRLDFDNRDYMAKRVNVIAHPSQLKMPSVDLNVFLELFPFTIVLDHDMKITLAGEKIVET 251
            ..:|| .|:.|..:..|....|:.|.:..|:....:: |:..||:.:|:|.|.||...|.:
 Worm   188 IFLVK-TLNTDQSNEEALGTAVVQHSNNYKIRLTHMD-FISTFPYHMVVDQDCKIVQVGRE---- 246

  Fly   252 WILHNPGVNPKTFIGSHILERFKCRRPKDTQIQWETI---------LQMRTVLFEFELIRTGHNR 307
              |:|........:|:.::..|:..||: ..:.:::|         ||::|...||:  |..:.|
 Worm   247 --LYNHIPKDLLSVGTPLMRIFEVTRPQ-IPLDFDSICNFINAVFVLQVKTTPMEFQ--RNANKR 306

  Fly   308 AAYDAALNFDFENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQRRHSVG 372
            |                     |||:.       ::||..|:...|.        |..|.:|
 Worm   307 A---------------------AQAIE-------ASENLYEDNNGAL--------ALSQSQH--- 332

  Fly   373 LRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLE- 436
               :.|||||..:.....:::||||.:.::.||...||.|..:..|..:|:|::...|..|.:|
 Worm   333 ---LKLKGQMMLMSSGGHIMYLCSPYVTSIPELLQYGLRLTAMPIHDPTRDLILLNQQRLSDVEM 394

  Fly   437 -IMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEV 500
             :..|...::.:.:.|.||:.   |.:.|.||..|:|..:|:::::......:.:||.:|:|.:|
 Worm   395 NLQLEANNEQLENMAKDLEVE---KGKTDALLREMLPPSVAQQLKQGLSVEAREYEEATVMFTDV 456

  Fly   501 MNIYDSGSNNIQDAMQAVT------TLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPL 559
                    ...|..:...|      .||::|:..|..|.....|||||||..||:|.|.||:...
 Worm   457 --------PTFQQIVPLCTPKDIVHLLNELFTKFDRLIGIQKAYKVETVGDSYMSVGGIPDLVDD 513

  Fly   560 HAEHACDLALRVMKKVKAHALP----GVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRME 620
            |.|..|.|||.::.:.:....|    .:.||.||:||||||||||.|:||||||||||||:||||
 Worm   514 HCEVICHLALGMVMEARTVCDPITNTPLHIRAGIHSGPVVAGVVGAKMPRYCLFGDTVNTSSRME 578

  Fly   621 SSSDPWMIQLSNYTALKVQKVG-YKVEARGFVKVKGKGEMETYWLL 665
            |.|....|..|.......:..| ::.|.||.|::||||||.||:||
 Worm   579 SHSPIGRIHCSENAKKCAESTGRFEFEPRGRVQIKGKGEMNTYFLL 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:462233	37/162 (23%)
		HNOBA	218..479	CDD:462234	65/271 (24%)
		Nucleotidyl_cyc_III	488..665	CDD:448371	80/187 (43%)
gcy-36	NP_510557.3	HNOB	3..167	CDD:462233	37/171 (22%)
		HNOBA	217..435	CDD:462234	65/272 (24%)
		CYCc	415..604	CDD:214485	75/199 (38%)