Protein Alignment Gyc89Db and gcy-17

DIOPT Version :10

• Sequence 1: NP_650551.1
• Gene: Gyc89Db / 42002
• FlyBaseID: FBgn0038436
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_001293327.1
• Gene: gcy-17 / 191649
• WormBaseID: WBGene00001542
• Length: 1088
• Species: Caenorhabditis elegans
• Alignment Length: 774
• Identity: 183/774 - (23%)
• Similarity: 287/774 - (37%)
• Gaps: 267/774 - (34%)

  Fly    20 ETWRKVCQIVDCKHQSFKTHQIYPDKLM-----------------------PDFAA--------- 52
            ||:.|:  |::  :||....|:|.|::|                       |||..
 Worm   425 ETYGKL--IIN--NQSVHFEQLYSDEVMDVWNGRQRPKAKPTCGFTGTQCPPDFVRDYLVIVIII 485

  Fly    53 ------ALSASTGESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNI-HVQMRFT 110
                  |:||:.|..|                     ..||...:.    ::..|.: ||:....
 Worm   486 VMFLIFAVSAAVGAVF---------------------YAIRQKRKE----IERQDELWHVEASHL 525

  Fly   111 YP---KMKSPSMQLTNMDDDGAVILYRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDIC 172
            .|   |.||.:.|.:          :.||.:..:|..:...||..:..:      |:.:.:|:
 Worm   526 KPISKKSKSEASQRS----------FASGPSTSTKLTVESRTETTRFIF------YIYQVRNN-- 572

  Fly   173 GGTAGPIKLTEGPLTVIVKYRLDFDNRDYMAKRVNVIAHPSQLK-MPSVD---LNVFLELFPFTI 233
                          .|:...:.||..:....:|       |:|: |.|:|   ||.|:.|
 Worm   573 --------------EVVAANKHDFRPQLTDVER-------SELRQMRSLDHDNLNKFIGL----- 611

  Fly   234 VLDHDMKITLAGEKIVETWILHNPGVNPKTFIGSHILERFKCRRPKDTQIQWETILQMRTVLFEF 298
                    .|..::::..|                   |: |.|.....:...:.:||.: .|..
 Worm   612 --------CLNSQQLLSIW-------------------RY-CSRGSLADVISRSSMQMDS-FFML 647

  Fly   299 ELIRTGHNRAAYDAALNFDFENFDEASS---------------LNEAQAMALASAKEFSAEN--- 345
            .|||...|...:.......|..:..:.|               |||.:.|     .:.|.||
 Worm   648 SLIRDIANGLGFIHTSMLHFHGYLSSRSCLIDDRWQVKISDFGLNEVRGM-----DKLSTENMLW 707

  Fly   346 -AKEEAAAAATSKDEIDPATGQRRHSVGLRSILLKGQMFYIKDVDSLIF--LCSPLI-------- 399
             |.|                            :|:|.....|:.|...|  :||.:|
 Worm   708 WAPE----------------------------VLRGLEQRSKEADIYSFGIICSEVITRSSAFDL 744

  Fly   400 ENLDELHGIGLY------LNDLNPHGLSRE----------LVMAGW------------------- 429
            ||..|.....:|      .|.:.|..|:.|          |:...|
 Worm   745 ENRKEKPEEIIYQLKKGGFNAIRPSLLTDEALEINPALVHLIRDCWTEKPSERPPIDQVRSLLRG 809

  Fly   430 ----QHCSKLEIMFEKEEQRSDELEKSL-----ELADSWKRQGDELLYSMIPRPIAERMRKSEEH 485
                :..:.::.:|...|..:..||:.:     ||.:..|: .|.|||.|:|:.:||:::.....
 Worm   810 MNDGKKGNLMDHVFNMLETYASTLEEEVNERTKELVEEQKK-SDVLLYRMLPKTVAEKLKAGISI 873

  Fly   486 VCQSFEEVSVIFIEVMNIYDSGSNNIQDAMQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAV 550
            ..::||.|::.|.:|:......|.  ...:|.|..||.:::..|..|....||||||:|..|:.|
 Worm   874 EPETFELVTIFFSDVVQFTTLASK--CTPLQVVQLLNDLYTIFDSIIEQNDVYKVETIGDGYLCV 936

  Fly   551 SGAPDVNPL-HAEHACDLALRVMKKVK----AHALPG--VAIRVGINSGPVVAGVVGMKVPRYCL 608
            ||.|..|.. |.:|...::|..:..:.    || :|.  :.:|:|||.|.|||||||:.:|||||
 Worm   937 SGLPHRNGHDHIKHIARMSLAFLSSLAEFRVAH-MPSERINLRIGINCGSVVAGVVGLTMPRYCL 1000

  Fly   609 FGDTVNTASRMESSSDPWMIQLSNYTALKVQKV--GYKVEARGFVKVKGKGEMETYWLL 665
            |||.|||||||||:..|..|.:|:.....:..|  |::.|.||.|.:||||.|.|||||
 Worm  1001 FGDAVNTASRMESNGKPGRIHVSSEANHLLTHVVGGFRTEERGEVIIKGKGVMNTYWLL 1059

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:462233	33/182 (18%)
		HNOBA	218..479	CDD:462234	62/336 (18%)
		Nucleotidyl_cyc_III	488..665	CDD:448371	77/185 (42%)
gcy-17	NP_001293327.1	PBP1_NPR_GC-like	25..421	CDD:380575
		Protein Kinases, catalytic domain	539..808	CDD:473864	61/374 (16%)
		HNOBA	<823..867	CDD:462234	15/44 (34%)
		CYCc	846..1038	CDD:214485	74/195 (38%)