Protein Alignment Gyc89Db and gcy-15

DIOPT Version :10

• Sequence 1: NP_650551.1
• Gene: Gyc89Db / 42002
• FlyBaseID: FBgn0038436
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_001364713.1
• Gene: gcy-15 / 191648
• WormBaseID: WBGene00001541
• Length: 1104
• Species: Caenorhabditis elegans
• Alignment Length: 823
• Identity: 213/823 - (25%)
• Similarity: 312/823 - (37%)
• Gaps: 266/823 - (32%)

  Fly     2 YGMLYESVQHYIQQEYGMETWRKVCQIVDCKHQSFKTHQIYPDKLMPDFAAALSA---------- 56
            ||.:..|:|.|.                   |.|..:|..|  .|.|....|.|:
 Worm   353 YGAIVGSMQIYY-------------------HFSSSSHNSY--SLFPCARLAQSSLLNTVWSLTD 396

  Fly    57 -STGESFDF-----------CMNFFG-RC-------FVRFFSNFGYDKMIRSTGRYFCDFLQSID 101
             |.|.|.||           | .|:| .|       |:          ::.|.|      :..:.
 Worm   397 YSEGLSIDFVNKSAPKDTPVC-GFYGENCGPPANNTFI----------IVISVG------VAVLI 444

  Fly   102 NIHVQMRFTYPKMKSPSM--QLTNMDDDGAVILYRSGRTGMSKYLIGQMTEVAKEFYGLDMTA-- 162
            .:.:...|.|.:.:....  .|..|.|...:||.:.... ||:..:..|..:.........|.
 Worm   445 GLAIAAAFLYKRYRYERRLHSLFFMIDRNQIILKKHTNL-MSQQSLRSMASIHGSVVAASQTLRD 508

  Fly   163 --YVLESQNDI----------CGGTA-----GPIK-----------------------LTEGPLT 187
              :.:|..|:.          .|.||     |||.                       |.|| .|
 Worm   509 SHFFIEDYNNASSINASSIFNTGSTARAGPFGPIPGFGGVTGASEDEKWHQIPDFGVGLYEG-RT 572

  Fly   188 VIVK--YRLDFD----NRDYMAK-----RVNVIAHPSQLKMPSVDLNVFLELF---PFTIVLDHD 238
            |.:|  ||.|.:    ||..:||     ..|||.....: :.|.|:.|..||.   ....:||:|
 Worm   573 VALKRIYRSDVEFTRSNRLEIAKLQESVNSNVIEFVGMV-VQSPDVFVVYELAQRGSLKDILDND 636

  Fly   239 -------MKITLAGEKIVETWILHNPGVNPKTFIGSH----------------ILERFKCR--RP 278
                   .:..:..:.|.....||:   :|   :|.|                .|..|..|  |.
 Worm   637 DMPLDDVFRSQMTKDIIAGLEYLHS---SP---VGCHGRLKSTNCLIDARWMVRLSSFGLRELRG 695

  Fly   279 KDTQIQWETILQMRTVLFEF-ELIR--TGHNRA---------AYDAALNFDFENF-------DEA 324
            ::|..|.:.:.:.:..|:.. ||:|  ||.::.         .|..|:.. :|.|       ||.
 Worm   696 EETWQQEDDVQEGKDQLWTSPELLRWSTGLSQCGVLLVQKSDVYSLAIVL-YELFGRLGPWGDEP 759

  Fly   325 SSLNEAQAM----ALASAKEFSAENA--KE------EAAAAATSKDEIDPATGQRRHSVGLRSIL 377
            ....|..::    |||..|.|..:.|  ||      |...||.::|
 Worm   760 MEPREIVSLVKREALAGKKPFRPDMAVLKESPRIVQETVVAAWTED------------------- 805

  Fly   378 LKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKE 442
                               ||  |...||.|...|..|. .||.|.:          ::.|....
 Worm   806 -------------------PL--NRPSLHQIKRKLKPLT-IGLKRTI----------MDNMVSMI 838

  Fly   443 EQRSDELEKSL----ELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNI 503
            |:.:|:|||.:    |..::.|.:.:.||..|:|..:|:.::.......:|||..:|.|.:....
 Worm   839 EKYTDKLEKDIAERNEELEAEKAKSEALLKMMLPEVVADSLKLGSNVSAESFENCTVFFSDCPGF 903

  Fly   504 YD-SGSNNIQDAMQAVTTLNKVFSALDEEIISPF-VYKVETVGMVYMAVSGAPDVNPLHAEHACD 566
            .: |.::...|.:|.:..|..||    :.||..| ||||||:...||..||.|..|..|  ||.:
 Worm   904 VEMSATSKPIDIVQFLNDLYTVF----DRIIDQFDVYKVETIADAYMVASGLPVPNGNH--HAGE 962

  Fly   567 LA------LRVMKKVKAHALPG--VAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSS 623
            :|      |:.::..|...||.  |.:|:|:||||.||||||:|:||||||||||||||||||:.
 Worm   963 IASLGLALLKAVESFKIRHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNG 1027

  Fly   624 DPWMIQLSNYTALKV--QKVGYKVEARGFVKVKGKGEMETYWL 664
            .|..|..|. ||.::  |..||::|.||.|::||||:..||::
 Worm  1028 IPLRINCSG-TAKEILDQLGGYEIEERGIVEMKGKGKQMTYFV 1069

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:462233	35/190 (18%)
		HNOBA	218..479	CDD:462234	69/323 (21%)
		Nucleotidyl_cyc_III	488..665	CDD:448371	84/189 (44%)
gcy-15	NP_001364713.1	Periplasmic_Binding_Protein_type1	2..363	CDD:471960	4/9 (44%)
		PK_GC	553..822	CDD:270894	68/317 (21%)
		HNOBA	<831..879	CDD:462234	13/47 (28%)
		Guanylate_cyc	885..1071	CDD:425528	84/192 (44%)