Protein Alignment Gyc89Db and gcy-20

DIOPT Version :10

• Sequence 1: NP_650551.1
• Gene: Gyc89Db / 42002
• FlyBaseID: FBgn0038436
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_507101.1
• Gene: gcy-20 / 184797
• WormBaseID: WBGene00001545
• Length: 1108
• Species: Caenorhabditis elegans
• Alignment Length: 695
• Identity: 177/695 - (25%)
• Similarity: 279/695 - (40%)
• Gaps: 168/695 - (24%)

  Fly     3 GMLYESVQHYIQQEYGMETWRKVCQIVDCKHQSFKTHQIYPDKLMPDFAAALSASTGESFDFCMN 67
            |:||  ..|..::|  ||....:.|:...:.|..:: :...:..|..||:..|.||.      |.
 Worm   495 GLLY--TMHMKRKE--MERQDLLWQVAFVELQQVQS-KSRAEASMHSFASGPSTSTK------MT 548

  Fly    68 FFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPKMKSPSMQLTNMDDDGAVIL 132
            ...|.....|..:.|.:.:.:..::  |.|...|          ...||...|:.|.|:|.
 Worm   549 VESRTETTNFIFYHYHQEVVAAKKH--DLLVLFD----------ANQKSEFRQMRNFDNDN---- 597

  Fly   133 YRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLTEGPLTVIVKYRLDFD 197
                               ..:|.||.:....|.|....|         :.|.|:
 Worm   598 -------------------LNKFIGLCLDGPQLLSLWRFC---------SRGSLS---------- 624

  Fly   198 NRDYMAKRVNVIAHPSQLKMPSVDLNVFLELFPFTIVLDHDMKITLAGEKIVETWILHNPGVNPK 262
              |.::|        |.::|.|        .|.|:::.|....:          :.:|:
 Worm   625 --DVISK--------SSMQMDS--------FFMFSLIRDISNGL----------YFIHS------ 655

  Fly   263 TFIGSHILERFKCRRPKDTQIQWETILQMRTVLFEFELIRTGHNR-------AAYDAALNFDFEN 320
            :|:..|.....:|....|   :|    |::...|..:.:||..|.       |:.:...|.|.|.
 Worm   656 SFLKCHGQLTSRCCLIDD---RW----QIKISGFGLKSVRTFENPKKEDLLWASPEYLRNEDQER 713

  Fly   321 FDEAS--SLNEAQAMALASAKEFSAENAKE--EAAAAATSKDEIDPA-----TGQRRHSVGLRSI 376
            ..|..  |.....|..|..:..|..||.||  :.......|...:|.     ||:   :|.:...
 Worm   714 LPEGDIYSFGIICAEILTRSSAFDLENRKEKPDVIIYQVKKGGHNPTRPSLDTGE---TVVINPA 775

  Fly   377 LLKGQMFYIKDVDSLIFLC-------SPLIENL-DELHGIGLYLNDLNPHGLSRELVMAGWQHCS 433
            ||    ..::|       |       .|.||.: ..|:|    :.|.....|...:......:.|
 Worm   776 LL----HLVRD-------CWTERPSERPSIEQVRSHLNG----MKDGRKTNLMDHVFNMLETYAS 825

  Fly   434 KLEIMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFI 498
            .||   |:...|:.||.:.       |::.|.|||.|:||.:|::::..:....::||:|::.|.
 Worm   826 TLE---EEVSDRTKELTEE-------KKKSDVLLYRMLPRMVADKLKLGQTVEPETFEQVTIFFS 880

  Fly   499 EVMNIYDSGSNNIQDAMQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPL-HAE 562
            :|:........  ...:|.||.||.:::..|..|....||||||:|..|:.|||.|..|.. |..
 Worm   881 DVVQFTTLAGK--CTPLQVVTLLNDLYTIFDGIIEQNDVYKVETIGDGYLCVSGLPHRNGNDHIR 943

  Fly   563 HACDLALRVMKKV---KAHALPG--VAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESS 622
            |...::|..:..:   :...||.  :.:|:|||.|.|||||||:.:||||||||.|||||||||:
 Worm   944 HIARMSLGFLSSLEFFRVQHLPAERINLRIGINCGSVVAGVVGLTMPRYCLFGDAVNTASRMESN 1008

  Fly   623 SDPWMIQLSNYTALKVQKV--GYKVEARGFVKVKGKGEMETYWLL 665
            ..|..|.::......:.:|  |::.|:||.|.:||||.|||:|||
 Worm  1009 GKPGQIHVTAEANRMLTQVVGGFRTESRGEVIIKGKGVMETFWLL 1053

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:462233	31/157 (20%)
		HNOBA	218..479	CDD:462234	60/284 (21%)
		Nucleotidyl_cyc_III	488..665	CDD:448371	75/184 (41%)
gcy-20	NP_507101.1	PBP1_NPR_GC-like	22..427	CDD:380575
		Protein Kinases, catalytic domain	536..801	CDD:473864	70/379 (18%)
		HNOBA	<817..861	CDD:462234	16/53 (30%)
		CYCc	840..1032	CDD:214485	72/200 (36%)