Protein Alignment Gyc89Db and gcy-18

DIOPT Version :10

• Sequence 1: NP_650551.1
• Gene: Gyc89Db / 42002
• FlyBaseID: FBgn0038436
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_502449.2
• Gene: gcy-18 / 178237
• WormBaseID: WBGene00001543
• Length: 1113
• Species: Caenorhabditis elegans
• Alignment Length: 666
• Identity: 162/666 - (24%)
• Similarity: 265/666 - (39%)
• Gaps: 160/666 - (24%)

  Fly    74 VRFFSNFGY---DKMIRSTGRYFCDFLQSIDNIHVQMRFTYPKMKSPSMQLTNMDDDGAVILYRS 135
            |.||..|.|   .::.:...|.|.|.||.||...|:...:   :.|.:.:|:|:
 Worm   514 VVFFFLFRYCENKQLEKMPWRIFHDDLQFIDEEQVKSMMS---VGSVTTKLSNI----------- 564

  Fly   136 GRTGMSKY-LIGQMTEVAKEFY-----------GLDMTAYVLESQNDICGGTAGPIKLTEGPLTV 188
             :||..:: :||..|......|           .:.:...:.::.:|......|.....:..:.|
 Worm   565 -QTGQKQHAIIGVNTHTTYHRYKQRRPIKFIKEDMQLLTQMKQAVHDNLNPFLGAAFNEKEEMLV 628

  Fly   189 IVKY--RLDFDNRDYMAKRVNVIA----HPSQLKMPSVDLNVFLE------------LFPFTIVL 235
            :.|:  |....:..|.|   ||:.    |.:.::    |:.:.||            |.|:..::
 Worm   629 LWKFCSRGTIQDIIYNA---NVVLDEKFHGAFVR----DITLGLEYLHASPIGYHGSLTPWCCLI 686

  Fly   236 DHDMKITLAGEKIVETWILHNPGVNPKTFIGSHILERFKCRRPKDTQIQWETILQMRTVLFEFEL 300
            |.:..:.|:...|          .||        |||            ||
 Worm   687 DRNWMVKLSDYGI----------ANP--------LER------------WE-------------- 707

  Fly   301 IRTGHNRAAYDAALNFDFENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATG 365
                 .:.|.:.|...|.::..:||.......||....|  :.|..|......:..|..:.....
 Worm   708 -----KQGAIEIAAAKDSDDKSQASQATSIIYMAPELLK--NRETNKRRGMDQSWVKQSMLRRQA 765

  Fly   366 QRRHSVG--LRSILLKGQMF-----------YIKDVDSLIFLCSPLIENLDELH-GIGLYLNDL- 415
            ...:|.|  :..||.:...|           |:.|....:   ||.|:|...|| .:...|.|.
 Worm   766 GDIYSFGMVMYEILFRSLPFRDNTNISELVDYLADGSKTV---SPEIQNQMGLHPDLNALLRDCW 827

  Fly   416 --NPH--------GLSRELVMAGWQHCSKLEIMFEKEEQRSDELEK-------SLELADSWKRQG 463
              ||.        .|:.|:|:.  ...|.::.|.:..||.::.|||       .||.|:.   :.
 Worm   828 SENPEIRPSIRRVRLNTEMVLK--TKGSLVDQMMKMMEQYANNLEKLVAERTGMLEEANI---RA 887

  Fly   464 DELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYD--SGSNNIQDAMQAVTTLNKVFS 526
            |:||..::|..:|..::.......:.:...:::|.:::....  |||.    .::.|..||.:::
 Worm   888 DQLLTQLLPAYVANELKMGRSVAPKLYSSATILFSDIVGFTTICSGST----PLEVVNMLNGLYT 948

  Fly   527 ALDEEIISPFVYKVETVGMVYMAVSGAPDVNPL-HAEHACDLALRVMKKVKAHALP-----GVAI 585
            ..||.|.....|||||:|..||.|||.|:.|.. |:.:..:.||.:.:.:..:.:|     .|..
 Worm   949 GFDECITRNKSYKVETIGDAYMVVSGIPEENEYNHSRNIANTALDMRQYLTGYQIPHRPTHRVRC 1013

  Fly   586 RVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSN--YTALKVQKVGYKVEAR 648
            |.|.::|.|.|||||:..|||||||||||.:|||||:..|.|||:|.  :..::.....:....|
 Worm  1014 RWGFHTGSVAAGVVGLTCPRYCLFGDTVNVSSRMESTGTPGMIQMSEEAHMHIRAHHPVFTTTER 1078

  Fly   649 GFVKVKGKGEMETYWL 664
            |.|:|||||...|:||
 Worm  1079 GEVQVKGKGTCRTFWL 1094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:462233	22/101 (22%)
		HNOBA	218..479	CDD:462234	61/304 (20%)
		Nucleotidyl_cyc_III	488..665	CDD:448371	69/187 (37%)
gcy-18	NP_502449.2	PBP1_NPR_GC-like	64..446	CDD:380575
		Protein Kinases, catalytic domain	549..846	CDD:473864	63/372 (17%)
		CYCc	882..1073	CDD:214485	64/197 (32%)