Protein Alignment Gyc89Db and Gucy2e

DIOPT Version :10

• Sequence 1: NP_650551.1
• Gene: Gyc89Db / 42002
• FlyBaseID: FBgn0038436
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: XP_036012232.1
• Gene: Gucy2e / 14919
• MGIID: 105123
• Length: 1139
• Species: Mus musculus
• Alignment Length: 687
• Identity: 172/687 - (25%)
• Similarity: 286/687 - (41%)
• Gaps: 184/687 - (26%)

  Fly    70 GRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPKMKSPSMQLTNMDDDGAVILYR 134
            |..||.|....|    :..||.:...:|:. ..:|:||      ...|:..:..::|  ...|:.
Mouse   498 GLVFVGFLLVIG----MGLTGAFLAHYLRH-RLLHMQM------ASGPNKIILTLED--VTFLHP 549

  Fly   135 SGRTGMSKYLI-GQMTEVAKEFYGLDMTAYVLESQNDICGGTAGP-----IKLTEGPLTVIVKYR 193
            .|  |.|:.:: |..:.:|            ..|.:||....:.|     :.|.||....:.|
Mouse   550 PG--GSSRKVVQGSRSSLA------------TRSASDIRSVPSQPQESTNVGLYEGDWVWLKK-- 598

  Fly   194 LDFDNRDYMAKRVNVIAHPSQLK-MPSVDLNVFLELF-------PFT-------IVLDH----DM 239
              |....:||.|.......|:|: :...::.::|.||       |.|       :|.:|    .:
Mouse   599 --FPGEHHMAIRPATKTAFSKLRELRHENVALYLGLFLAGTADSPATPGEGILAVVSEHCARGSL 661

  Fly   240 KITLAGEKIVETWI---------------LHNPGVNPKTFIGSHILERFKCRRPKDTQIQWETIL 289
            ...||..:|...|:               ||:.||       :|  .|.|.|         ..::
Mouse   662 HDLLAQREIKLDWMFKSSLLLDLIKGMRYLHHRGV-------AH--GRLKSR---------NCVV 708

  Fly   290 QMRTVLFEFELIRTGHNRAAYDAALNFDFENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAA 354
            ..|.||   ::...||.|                   |.|||.:                .....
Mouse   709 DGRFVL---KVTDHGHGR-------------------LLEAQRV----------------LPEPP 735

  Fly   355 TSKDEI--------DPATGQRRHSVG--------LRSILLKGQMF---------YIKDVDSLIFL 394
            :::|::        ||:..:|....|        ::.::.:...:         .|:.|.|...|
Mouse   736 SAEDQLWTAPELLRDPSLERRGTLAGDVFSLAIIMQEVVCRSTPYAMLELTPEEVIQRVRSPPPL 800

  Fly   395 CSPLIENLDE--LHGIGLYLN------DLNPHGLSRELVMAGWQHCSK------LEIMFEKEEQR 445
            |.||: ::|:  :..|.|...      :|.|   |.:|....::..:|      ::.|....||.
Mouse   801 CRPLV-SMDQAPMECIQLMTQCWAEHPELRP---SMDLTFDLFKSINKGRKTNIIDSMLRMLEQY 861

  Fly   446 SDELE----KSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDS 506
            |..||    :..|..:..|::.|.||..|:|..:||.::.......:.||||::.|.:::..  :
Mouse   862 SSNLEDLIRERTEELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVGF--T 924

  Fly   507 GSNNIQDAMQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVN-PLHAEHACDLALR 570
            ..:.:.:.::.|..||.:::..|..|.:..||||||:|..||..||.|..| ..||....:::|.
Mouse   925 TISAMSEPIEVVDLLNDLYTLFDAIIGAHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLD 989

  Fly   571 VMKKV---KAHALP--GVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMI-- 628
            ::..|   :...:|  .|.||:|::|||.||||||:.:||||||||||||||||||:..|:.|
Mouse   990 ILSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHV 1054

  Fly   629 QLSNYTALKVQKVGYKVEARGFVKVKGKGEMETYWLL 665
            .:|....|:....|:::|.||..::||||..:||||:
Mouse  1055 NMSTVRILRALDQGFQMECRGRTELKGKGIEDTYWLV 1091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:462233	19/91 (21%)
		HNOBA	218..479	CDD:462234	64/336 (19%)
		Nucleotidyl_cyc_III	488..665	CDD:448371	74/184 (40%)
Gucy2e	XP_036012232.1	PBP1_sensory_GC_DEF-like	58..465	CDD:380594
		PK_GC-2D	570..845	CDD:270945	61/338 (18%)
		HNOBA	<854..899	CDD:462234	15/44 (34%)
		CYCc	879..1070	CDD:214485	72/192 (38%)