DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gyc89Db and Gucy2d

DIOPT Version :10

Sequence 1:NP_650551.1 Gene:Gyc89Db / 42002 FlyBaseID:FBgn0038436 Length:669 Species:Drosophila melanogaster
Sequence 2:NP_001124165.1 Gene:Gucy2d / 14918 MGIID:106030 Length:1117 Species:Mus musculus


Alignment Length:577 Identity:157/577 - (27%)
Similarity:245/577 - (42%) Gaps:133/577 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   166 ESQNDICGGTAGPIKLTEGPL---------TVIVKYRLDFDNRDYMAKRVNVIAHPSQL------ 215
            ||::.:.||:  |..:|:|..         |.:..|:.::.........|.....||.|      
Mouse   542 ESRSVVDGGS--PRSVTQGSARSLPAFLEHTNVALYQGEWVWLKKFEAGVAPDLRPSSLSFLRKL 604

  Fly   216 -KMPSVDLNVFLELF----PFTIVLDH----DMKITLAGEKIVETWILHNPGVNPKTFIGSHILE 271
             :|...::..||.||    ...:||:|    .::..|..|.:...|          ||..|.:|:
Mouse   605 REMRHENVTAFLGLFVGPGVSAMVLEHCARGSLEDLLQNENLRLDW----------TFKASLLLD 659

  Fly   272 -----------RFKCRRPKDTQIQWETILQMRTVLFEFELIRTGHNRAAYDAALNFDFENFDEAS 325
                       ||...|.|......:|         .|.|..|.|..|        :|.....:|
Mouse   660 LIRGLRYLHHRRFPHGRLKSRNCVVDT---------RFVLKITDHGYA--------EFLESHCSS 707

  Fly   326 SLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQRRHSVGLRSILLKGQMF------- 383
            ....|....|.:|.|......|      ||.|.::...      ::.|:.:|.:...:       
Mouse   708 RPQPAPEELLWTAPELLRGPGK------ATFKGDVFSL------AIILQEVLTRDPPYCSWGLSA 760

  Fly   384 --YIKDVDSLIFLCSPLIE------------------------NLDELHGIGLYLNDLNPHGLSR 422
              .|:.|.|...||.||:.                        :||:::   .....:| .|...
Mouse   761 EEIIRKVASPPPLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIY---TQFKSIN-QGKKT 821

  Fly   423 ELVMAGWQHCSKL-EIMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHV 486
            .:|.:..:...|. |.:.:..::|::|||  ||     :|:.:.||..|:|..:|..::......
Mouse   822 SVVDSMLRMLEKYSESLEDLVQERTEELE--LE-----RRKTERLLSQMLPPSVAHALKMGTTVE 879

  Fly   487 CQSFEEVSVIFIEVMNIYDSGSNNIQDAMQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVS 551
            .:.|::|::.|.:::..  :..:.:.:.::.|..||.:::..|..:.|..||||||:|..||..|
Mouse   880 PEYFDQVTIYFSDIVGF--TTISALSEPIEVVGFLNDLYTLFDAVLDSHDVYKVETIGDAYMVAS 942

  Fly   552 GAPDVN-PLHAEHACDLALRVMKKV----KAHALPGVAIRV--GINSGPVVAGVVGMKVPRYCLF 609
            |.|..| ..||....:|||.::...    ..|| |.|.|||  |::|||.||||||:.:||||||
Mouse   943 GLPRRNGNRHAAEIANLALDILSYAGNFRMRHA-PDVPIRVRAGLHSGPCVAGVVGLTMPRYCLF 1006

  Fly   610 GDTVNTASRMESSSDPWMIQLSNYT--ALKVQKVGYKVEARGFVKVKGKGEMETYWL 664
            ||||||||||||:..|:.|.:|..|  ||.....|||::.||..::||||..|||||
Mouse  1007 GDTVNTASRMESTGLPYRIHVSQSTVQALLSLDEGYKIDVRGQTELKGKGLEETYWL 1063

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc89DbNP_650551.1 HNOB 2..161 CDD:462233
HNOBA 218..479 CDD:462234 62/313 (20%)
Nucleotidyl_cyc_III 488..665 CDD:448371 81/186 (44%)
Gucy2dNP_001124165.1 PBP1_sensory_GC_DEF-like 71..445 CDD:380594
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 529..557 5/16 (31%)
PK_GC-2D 554..818 CDD:270945 55/306 (18%)
CYCc 855..1044 CDD:214485 74/191 (39%)
Interaction with NCALD. /evidence=ECO:0000250|UniProtKB:P51839 874..915 6/42 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1096..1117
Blue background indicates that the domain is not in the aligned region.

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