DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gyc89Db and Gucy2e

DIOPT Version :10

Sequence 1:NP_650551.1 Gene:Gyc89Db / 42002 FlyBaseID:FBgn0038436 Length:669 Species:Drosophila melanogaster
Sequence 2:NP_570093.2 Gene:Gucy2e / 113911 RGDID:69322 Length:1123 Species:Rattus norvegicus


Alignment Length:539 Identity:144/539 - (26%)
Similarity:223/539 - (41%) Gaps:150/539 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   212 PSQL-------KMPSVDLNVFLELF----PFTIVLDH----DMKITLAGEKIVETWILHNPGVNP 261
            ||.|       :|...::..||.||    ...:||:|    .::..|..|.:...|         
  Rat   595 PSSLSLLRKMREMRHENVTAFLGLFVGPEVSAMVLEHCARGSLEDLLRNEDLRLDW--------- 650

  Fly   262 KTFIGSHILE-----------RFKCRRPKDTQIQWETILQMRTVLFEFELIRTGHNRAAYDAALN 315
             ||..|.:|:           .|...|.|......:|         .|.|..|.|..|.:     
  Rat   651 -TFKASLLLDLIRGLRYLHHRHFPHGRLKSRNCVVDT---------RFVLKITDHGYAEF----- 700

  Fly   316 FDFENFDEASSLNEAQAMALASAKEFSAENAKEE----------------AAAAATSKDEIDPAT 364
                               |.|...|..:.|.||                ....||.|.::    
  Rat   701 -------------------LESHCSFRPQPAPEELLWTAPELLRGPRRPWGPGKATFKGDV---- 742

  Fly   365 GQRRHSVG--LRSILLKGQMF---------YIKDVDSLIFLCSPLIE------------------ 400
                .|:|  |:.:|.:...:         .|:.|.|...||.||:.                  
  Rat   743 ----FSLGIILQEVLTRDPPYCSWGLSAEEIIRKVASPPPLCRPLVSPDQGPLECIQLMQLCWEE 803

  Fly   401 ------NLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLELADSW 459
                  :||:::.....:|......::..::....::...||.:.   ::|::|||  ||     
  Rat   804 APDDRPSLDQIYTQFKSINQGKKTSVADSMLRMLEKYSQSLEGLV---QERTEELE--LE----- 858

  Fly   460 KRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDSGSNNIQDAMQAVTTLNKV 524
            :|:.:.||..|:|..:|..::.......:.|::|::.|.:::..  :..:.:.:.::.|..||.:
  Rat   859 RRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQVTIYFSDIVGF--TTISALSEPIEVVGFLNDL 921

  Fly   525 FSALDEEIISPFVYKVETVGMVYMAVSGAPDVN-PLHAEHACDLALRVMKKV----KAHALPGVA 584
            ::..|..:.|..||||||:|..||..||.|..| ..||....::||.::...    ..|| |.|.
  Rat   922 YTMFDAVLDSHDVYKVETIGDAYMVASGLPRRNGNRHAAEIANMALEILSYAGNFRMRHA-PDVP 985

  Fly   585 IRV--GINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYT--ALKVQKVGYKV 645
            |||  |::|||.||||||:.:||||||||||||||||||:..|:.|.:|..|  ||.....|||:
  Rat   986 IRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSRNTVQALLSLDEGYKI 1050

  Fly   646 EARGFVKVKGKGEMETYWL 664
            :.||..::||||..|||||
  Rat  1051 DVRGQTELKGKGLEETYWL 1069

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc89DbNP_650551.1 HNOB 2..161 CDD:462233
HNOBA 218..479 CDD:462234 60/330 (18%)
Nucleotidyl_cyc_III 488..665 CDD:448371 80/186 (43%)
Gucy2eNP_570093.2 PBP1_sensory_GC_DEF-like 71..445 CDD:380594
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 529..556
PK_GC-2D 554..824 CDD:270945 50/279 (18%)
CYCc 861..1050 CDD:214485 73/191 (38%)
Interaction with NCALD. /evidence=ECO:0000269|PubMed:18178149 880..921 6/42 (14%)
Blue background indicates that the domain is not in the aligned region.

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