Protein Alignment Gyc89Db and gucy1b1

DIOPT Version :10

• Sequence 1: NP_650551.1
• Gene: Gyc89Db / 42002
• FlyBaseID: FBgn0038436
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: XP_004911214.1
• Gene: gucy1b1 / 100379900
• XenbaseID: XB-GENE-950986
• Length: 618
• Species: Xenopus tropicalis
• Alignment Length: 691
• Identity: 193/691 - (27%)
• Similarity: 321/691 - (46%)
• Gaps: 113/691 - (16%)

  Fly     1 MYGMLYESVQHYIQQEYGMETW---RKVCQIVDCKHQSFKTHQIYPDKLMPDFAAA----LSAST 58
            |||.:..:::..:.:.||.|.|   :|..|:.:  ...|....||.|....|..:|    |:.:.
 Frog     1 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDE--EGQFLVRIIYDDSKTYDLVSAATKVLNLNA 63

  Fly    59 GESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPKMKSPSMQLTN 123
            |:    .:..||..|..|....|||.::|..|....:|||::|.:|..:...||.|::||.:.|:
 Frog    64 GD----ILQMFGNMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLGTIYPGMRAPSFRCTD 124

  Fly   124 MD-DDGAVILYRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLTEGPLT 187
            .: ..|.::.|.|.|.|:...:||.:..||::.:|.::...|::.:|:.|..|...|:..:....
 Frog   125 AEKGKGLILHYYSEREGLQDIVIGIVKTVAQQIHGTEIDMKVIQQRNEECDHTQFLIEEKDTREE 189

  Fly   188 VIVKYRLDFDNRDYMAKRVNVIAHPSQLKMPSVDLNVFLELFPFTIVLDHDMKITLAGEKIVETW 252
            ...:.:..|:.......|::..              .|.:.|||.|:.|.|:.:|..|..|....
 Frog   190 DFYEDQDRFEENGTQESRISPY--------------TFCKAFPFHIMFDRDLFVTQCGNAIYRVL 240

  Fly   253 ILHNPGVNPKTFIGSHILERFKCRRPKDTQIQWETILQMRTVLFEFELIRTGHNRAAYDAALNFD 317
            ....||               .|                 .:|..|.|:|. |        ::..
 Frog   241 PQLQPG---------------NC-----------------NLLSVFSLVRP-H--------IDIS 264

  Fly   318 FENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQRRHSVGLRSILLKGQM 382
            |...     |:....:.:..:||...:..|.|      |:||:   ||..     :..:.|||||
 Frog   265 FHGI-----LSHINTVFVLRSKEGLLDVEKSE------SEDEL---TGTE-----ISCLRLKGQM 310

  Fly   383 FYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQH------CSKLEIMFEK 441
            .|:.:.|:::|||||.:.|||:|...||||:|:..|..:|:||:.|.|.      ..:|||:
 Frog   311 IYLPEADNILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEIL--- 372

  Fly   442 EEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVM--NIY 504
                :|.|:.:|...:..|::.|.||||::|..:|..:|.......:.::.|:::|..::  |.:
 Frog   373 ----TDRLQHTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNTF 433

  Fly   505 DSGSNNIQDAMQAVTTLNKVFSALD---EEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACD 566
            .|...:.:.||:.|..||.:::..|   :...:|:||||||||..||.|||.|:....||...|.
 Frog   434 CSKHASGEGAMKIVNLLNDIYTRFDILTDSRNNPYVYKVETVGDKYMTVSGIPEPCVHHARSICH 498

  Fly   567 LALRVMKKVKAHALPG--VAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQ 629
            |||.:|:......:.|  |.|.:||::|.||.||:|.::|||||||:|||..||.|::.:...|.
 Frog   499 LALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKIN 563

  Fly   630 LSNYT-----ALKVQKVGYKVEARGFVKVKGKGEMETYWLL 665
            :|.||     :.:.....:.::.||.|.:|||.:....|.|
 Frog   564 VSEYTYRCLMSPENSDPQFHLQYRGPVSMKGKTDPMQVWFL 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:462233	46/166 (28%)
		HNOBA	218..479	CDD:462234	70/266 (26%)
		Nucleotidyl_cyc_III	488..665	CDD:448371	67/188 (36%)
gucy1b1	XP_004911214.1	HNOB	2..166	CDD:462233	46/169 (27%)
		HNOBA	207..406	CDD:462234	71/279 (25%)
		Guanylate_cyc	412..605	CDD:425528	68/193 (35%)