Protein Alignment Gyc89Db and gucy1b1

DIOPT Version :10

• Sequence 1: NP_650551.1
• Gene: Gyc89Db / 42002
• FlyBaseID: FBgn0038436
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_001238874.1
• Gene: gucy1b1 / 100150304
• ZFINID: ZDB-GENE-090313-160
• Length: 608
• Species: Danio rerio
• Alignment Length: 689
• Identity: 195/689 - (28%)
• Similarity: 321/689 - (46%)
• Gaps: 109/689 - (15%)

  Fly     1 MYGMLYESVQHYIQQEYGMETWRKVCQ--IVDCKHQSFKTHQIYPDKLMPDFAAALSASTGESFD 63
            |||.:..:::..:.:.||.:.|..:.:  .||.:.| |....||.|....|..||.|........
Zfish     1 MYGFVNHALELLVLRNYGPDVWEDIKREAQVDVEGQ-FLVRIIYEDAKTYDLVAAASKVLKMDAG 64

  Fly    64 FCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPKMKSPSMQLTNMDDDG 128
            ..:..||:.|..|....|||.::|..|....:|||::|.:|..:...||.|::||.:.|:.:...
Zfish    65 GILQMFGKMFFEFCQESGYDTILRVLGSNVREFLQNLDALHDHLGTIYPGMRAPSFRCTDAEKGN 129

  Fly   129 AVIL-YRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLTEGPLTVIVKY 192
            .:|| |.|.|.|:...:||.:..||::.:|.::...|::.:::.|......|:..:.......:.
Zfish   130 NLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIEMKVIQPKSEECDHIKFLIEEKDSEEEAFYED 194

  Fly   193 RLDFDNRDYMAKRVNVIAHPSQLKMPSVDLNVFLELFPFTIVLDHDMKITLAGEKIVETWILHNP 257
            ...|:.......|::..              .|.:.|||.::.|.|:.:|..|..|........|
Zfish   195 LDGFEENGTQETRISPY--------------TFCKAFPFHLMFDKDLMLTQCGNAIFRVLPQLQP 245

  Fly   258 GVNPKTFIGSHILERFKCRRPKDTQIQWETILQMRTVLFEFELIRTGHNRAAYDAALNFDFENFD 322
            ||               |              .:.:|   |.|:|. |        ::|.|...
Zfish   246 GV---------------C--------------NLSSV---FSLVRP-H--------IDFSFHGI- 268

  Fly   323 EASSLNEAQAMALASAKE--FSAENAKEEAAAAATSKDEIDPATGQRRHSVGLRSILLKGQMFYI 385
                |:....:.:..:||  .:.|.|:.|           |..||..     :..:.|||||..:
Zfish   269 ----LSHINTVFVLRSKEGLLNVETAENE-----------DELTGTE-----ISCLRLKGQMISL 313

  Fly   386 KDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQH------CSKLEIMFEKEEQ 444
            .:.::::|||||.:.|||:|...||||:|:..|..:|:||:.|.|.      ..:|||:
Zfish   314 PETENILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEIL------ 372

  Fly   445 RSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVM--NIYDSG 507
             :|.|:.:|...:..|::.|.||||::|..:|..:|.......:.::.|:::|..::  |.:.|.
Zfish   373 -TDRLQHTLRALEDEKKKTDRLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSK 436

  Fly   508 SNNIQDAMQAVTTLNKVFSALD---EEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLAL 569
            ..:.:.|::.|..||.:::..|   :...:|:||||||||..||.|||.|:....||:..|.|||
Zfish   437 HASAEGAIKIVNLLNDIYTRFDILTDSRKNPYVYKVETVGDKYMTVSGLPEPCTHHAKSICHLAL 501

  Fly   570 RVMK---KVKAHALPGVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLS 631
            .:|:   :||....| |.|.:||::|.||.||:|.::|||||||:|||..||.|::.:...|.:|
Zfish   502 DMMEIAGQVKVDEDP-VQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVS 565

  Fly   632 NYTALKVQKV-----GYKVEARGFVKVKGKGEMETYWLL 665
            .||...:|.|     .:.:|.||.|.:|||.|....|.|
Zfish   566 EYTYRCLQSVENADPQFHLEYRGPVTMKGKKEPMKVWFL 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:462233	47/161 (29%)
		HNOBA	218..479	CDD:462234	68/268 (25%)
		Nucleotidyl_cyc_III	488..665	CDD:448371	72/189 (38%)
gucy1b1	NP_001238874.1	HNOB	2..166	CDD:462233	47/164 (29%)
		HNOBA	207..406	CDD:462234	69/281 (25%)
		Guanylate_cyc	412..605	CDD:425528	73/194 (38%)