Protein Alignment CG6126 and Slc22a2

DIOPT Version :10

• Sequence 1: NP_650528.1
• Gene: CG6126 / 41967
• FlyBaseID: FBgn0038407
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_113772.1
• Gene: Slc22a2 / 29503
• RGDID: 61936
• Length: 593
• Species: Rattus norvegicus
• Alignment Length: 578
• Identity: 176/578 - (30%)
• Similarity: 284/578 - (49%)
• Gaps: 52/578 - (8%)

  Fly     7 LEDLMGKLGEFGKYQFLQFF-LQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSVTPWNS 70
            ::|::..:|||..:|...|| |.:|||....:: :.:|.:...|:|.|:..|....| ....|:.
  Rat     4 VDDILEHIGEFHLFQKQTFFLLALLSGAFTPIY-VGIVFLGFTPDHHCWSPGAAKLS-QRCGWSQ 66

  Fly    71 SAIL-AAIP-LKPNGE---LESCLMFDPSSPGTNTTINC--------------------ERYVYD 110
            :..| ..:| |.|:.|   |..|:.::..  ...:|::|                    ..:||:
  Rat    67 AEELNYTVPGLGPSDEASFLSQCMRYEVD--WNQSTLDCVDPLSSLAADRNQLPLGPCEHGWVYN 129

  Fly   111 TTYYKTSRTIDWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGV 175
            |.  .:|...::|.||...||..:.|:|..:|.|.||:.:|.|||:.|||.....:.|...|.|.
  Rat   130 TP--GSSIVTEFNLVCAHSWMLDLFQSVVNVGFFIGAMMIGYLADRFGRKFCLLVTILINAISGA 192

  Fly   176 GVAFIPEYFSFMVARYLLGIVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLVAGWG 240
            .:|..|.|...:|.|:|.|:|..|| ::.|::|..|.||...|.:.||.:|..|..|::::||..
  Rat   193 LMAISPNYAWMLVFRFLQGLVSKAG-WLIGYILITEFVGLGYRRMVGICYQIAFTVGLLILAGVA 256

  Fly   241 ALIPDRQWLQVIYGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIPVDKEYY 305
            .:||:.:|||....|....||.::|.:.||||||..|.:..:|:.|:....:.||..:||.
  Rat   257 YVIPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKIVKAMKIIKHIAKKNGKSVPVS---- 317

  Fly   306 VQKAKQQAAAEEKSSAGLSDLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYLILFI 370
            :|.......|.:|....:.||.|||.:|..||.:...||.:|::|.||.:..|....|.||..|.
  Rat   318 LQNLTPDEDAGKKLKPSILDLVRTPQIRKHTLILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFY 382

  Fly   371 MGLVEFPSYITIVFVLDRLGRRSITSTLMLGGGLCCIVAAYIAQG-STTSTAVVMAGKLLIAGSF 434
            ..|||||:...|:..:||:|||...:...:..|..|:.:.:|... ......:...|::.|..::
  Rat   383 SALVEFPAAFIIILTIDRVGRRYPWAVSNMVAGAACLASVFIPDDLQWLKITIACLGRMGITMAY 447

  Fly   435 AVIYNYSAELFPTVVRN-SAMGLGSMCARLSGALTP-LITLLDSFDPKIPAVLFGVVALISGFWV 497
            .::...:|||:||.:|| ..:...||| .:.|.:|| |:..|.....:.|.|:|.||.|::|..|
  Rat   448 EMVCLVNAELYPTYIRNLGVLVCSSMC-DIGGIITPFLVYRLTDIWMEFPLVVFAVVGLVAGALV 511

  Fly   498 MFLPETMNQPMPESIEDGENFGKGDTWFSQCAGRKKRQNSVYPDD---PEQMVPLKNI 552
            :.||||..:.:||:|||.||.        |...:|:|:.::.|..   |...:..|.|
  Rat   512 LLLPETKGKALPETIEDAENM--------QRPRKKERKENLPPSQASRPSAKLKRKGI 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	161/523 (31%)
Slc22a2	NP_113772.1	2A0119	12..525	CDD:273328	162/524 (31%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O15244	284..288		2/3 (67%)