Protein Alignment CG6126 and SV2C

DIOPT Version :10

• Sequence 1: NP_650528.1
• Gene: CG6126 / 41967
• FlyBaseID: FBgn0038407
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_055794.3
• Gene: SV2C / 22987
• HGNCID: 30670
• Length: 727
• Species: Homo sapiens
• Alignment Length: 673
• Identity: 134/673 - (19%)
• Similarity: 212/673 - (31%)
• Gaps: 280/673 - (41%)

  Fly    18 GKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSVTPWNSSAILAAIPLKPN 82
            |::|:..||:..::.:..|:.:              |:.|.                    :.|:
Human   148 GRFQWALFFVLGMALMADGVEV--------------FVVGF--------------------VLPS 178

  Fly    83 GELESCLMFDPSSPGTNTTINCERYVYDTTYYKTSRTIDWNFVCDRRWMGAIVQTVFMLGVFTGA 147
            .|.:.|:   |:| |:.                              |:|:||    .||:..||
Human   179 AETDLCI---PNS-GSG------------------------------WLGSIV----YLGMMVGA 205

  Fly   148 VTLGGLADKVGRK--TVFCWS--ALFQLIIGVGVAFIPEYFSFMVARYLLGIVGSAGAYICGFVL 208
            ...||||||||||  .:.|.|  ..|..:    .:|:..|..|:..|.|.|. |..||....|..
Human   206 FFWGGLADKVGRKQSLLICMSVNGFFAFL----SSFVQGYGFFLFCRLLSGF-GIGGAIPTVFSY 265

  Fly   209 TMELVGPTKRTVCG--ITFQAVF--AGGIMLVAGWGALIPDRQWLQVIYGLHGCLFLGHWW---- 265
            ..|::...||   |  :::..:|  .|||...|...|:||...|...:    |..:..|.|
Human   266 FAEVLAREKR---GEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSM----GSAYQFHSWRVFV 323

  Fly   266 ---------------WLDESPRWLWMQGRAAEAVDIVA----KGLRINGSGIPVDKEYYVQKAKQ 311
                           ::.||||:|...|:..||..|:.    ..:|..|.   .:|.:.|.|.|.
Human   324 IVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQ---PEKVFTVNKIKT 385

  Fly   312 QAAAEE----KSSAGL----------SDL----------FRTPNLRMKTLNVCLCWFANSLVYYG 352
            ....:|    :|..|.          ::|          |..| :|..|:.:.:.||..|..|||
Human   386 PKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYP-VRDNTIKLTIVWFTLSFGYYG 449

  Fly   353 LS---------------------------------------LSAGKLYGNP-------------- 364
            ||                                       :..|..|.|.
Human   450 LSVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKD 514

  Fly   365 ----------------------------------------------------------------- 364
                                                                             
Human   515 SVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSA 579

  Fly   365 ---YLILFIMGLVEFPSYITIVFVLDRLGRRSITSTLMLGGGLCCIVAAYIAQGSTTSTAVVMAG 426
               |.:.|:..|...|..|....::||:||.::....|:..|:.|.   ::..|::.|   :|.|
Human   580 YWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCF---FLWFGTSES---MMIG 638

  Fly   427 KLLIAGSFAV-IYN----YSAELFPTVVRNSAMG-LGSMC--ARLSGALTPLITLLDSFDPKIPA 483
            .|.:.....: .:|    .:.||:||..|.:..| |.::|  |.:.|.|  :...|.|....||.
Human   639 MLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNL--IFGSLVSITKSIPI 701

  Fly   484 VLFGVVALISGFWVMFLPETMNQ 506
            :|...|.:..|...:.||:|..|
Human   702 LLASTVLVCGGLVGLCLPDTRTQ 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	134/673 (20%)
SV2C	NP_055794.3	synapt_SV2	1..727	CDD:130366	134/673 (20%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..84
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	109..128
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269|PubMed:27294781	519..563		0/43 (0%)