DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and MPDZ

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001362342.1	Gene:	MPDZ / 8777	HGNCID:	7208	Length:	2103	Species:	Homo sapiens

Alignment Length:	1439	Identity:	287/1439 - (19%)
Similarity:	457/1439 - (31%)	Gaps:	468/1439 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 PEQDRGNEEIVASVMTHIESRASNGAGVSVNYSEVTHSLLSGGLKNRFLPPIPPKPPKRGILKGS 171
            ||.|.     :.|....|.|...:..|..:||..                .:|..||| .:::.|
Human   847 PENDS-----IYSTQASILSLHGSSCGDGLNYGS----------------SLPSSPPK-DVIENS 889

  Fly   172 RSNMTNVH---EEI--------------SFAGSAGGAGG------TPEMLLRNTFQNES------ 207
            ...:.::|   ||:              |...|.|.|.|      ||...:...::.|:
Human   890 CDPVLDLHMSLEELYTQNLLQRQDENTPSVDISMGPASGFTINDYTPANAIEQQYECENTIVWTE 954

  Fly   208 ----------------LYEGAARGA------GSIGSNSSQHGTSFTSVESL-RSDGEQTGGQQRA 249
                            |.:.|.:|:      .|:..|:........|.||. |:.....|.....
Human   955 SHLPSEVISSAELPSVLPDSAGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLG 1019

  Fly   250 MTLPAN-----------------ARYGALPQGNSQGSHLHVLTSPSPSADSLTDT------TNSS 291
            ||:.||                 :|.|.:..|:.      :|:....|..|:|:.      ...|
Human  1020 MTVSANKDGLGMIVRSIIHGGAISRDGRIAIGDC------ILSINEESTISVTNAQARAMLRRHS 1078

  Fly   292 FATPPFSLSPV------------GESQGIDRWARVHAFE--------DV-ELP-----------L 324
            ...|...::.|            |:..|     ||.|.:        |: |||           |
Human  1079 LIGPDIKITYVPAEHLEEFKISLGQQSG-----RVMALDIFSSYTGRDIPELPEREEGEGEESEL 1138

  Fly   325 PPVQLVKLPPPRQLVIRRQKSPRQDFGFSL----RKAICLDRTESLTSPIFRPVIFAEPGAGGGA 385
            ..........||::.:.|:  |.:..|.|:    .....|...|.:.....:.|:...|....|.
Human  1139 QNTAYSNWNQPRRVELWRE--PSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGT 1201

  Fly   386 TGLLPGDRLIKVNGTPVGELPREIIIEMIRNSGEAVTVEVQPVAELVELSKRCMAPSTA--TVEE 448
              |.||||:::|:|..:.:...|..:|.||.:|..|...||   .::...::...||..  ...:
Human  1202 --LKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQ---SIINRPRKSPLPSLLHNLYPK 1261

  Fly   449 IDHSITNGNCNTLRRSASKRFKRQSRHENGNGGGEEGGAKGVGHDLEADVADASQPERVWLVHRG 513
            .:.|.||...::|:.:|.|                            |.....|:||:..|
Human  1262 YNFSSTNPFADSLQINADK----------------------------APSQSESEPEKAPL---- 1294

  Fly   514 GFTAAIRLPTASS----GRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNE 574
               .::..|..|:    |.|          |.....:....||:|         ||.....:.|
Human  1295 ---CSVPPPPPSAFAEMGSD----------HTQSSASKISQDVDK---------EDEFGYSWKN- 1336

  Fly   575 ASVLHCLRQRYAS-----NLIHTKAGPTLLVVNPMAPLSLYSEK---VVSMF------RGCKTED 625
                  :|:||.:     ::|..:.|.:.|      .|||...|   .:|:|      .|...:|
Human  1337 ------IRERYGTLTGELHMIELEKGHSGL------GLSLAGNKDRSRMSVFIVGIDPNGAAGKD 1389

  Fly   626 MPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFI-NAEKVN- 688
                  ...|.| ..|:|.   ...|..|||....|:..|.|.:.:.:.      || |.:.||
Human  1390 ------GRLQIA-DELLEI---NGQILYGRSHQNASSIIKCAPSKVKII------FIRNKDAVNQ 1438

  Fly   689 -ALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHI 752
             |:|.     ||....|.||:..:         |..::......:....||.:      .|..::
Human  1439 MAVCP-----GNAVEPLPSNSENL---------QNKELGYHRFSLYSKPRQSS------SHLVYL 1483

  Fly   753 MTRLLAGAAGLLQKELHLENITSEDSHPFISLS-----QKLE----------------------- 789
            .::|:|       .:|||...|...|...:.||     |.||
Human  1484 CSQLIA-------VQLHLTEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVII 1541

  Fly   790 ---DRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVT-KLGTGSTARTQFANPT 850
               ..|..|....|.....:.|.:|.:.|.| :.|...|..|..|.:| ||...:......|.|:
Human  1542 KSLTEHGVAATDGRLKVGDQILAVDDEIVVG-YPIEKFISLLKTAKMTVKLTIHAENPDSQAVPS 1605

  Fly   851 AARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSP---TSD-------TGHEWAWECLEAL 905
            ||..|||....:.:.|.....|..:|.:.. ..|.|.:|   .||       .|.|...|..:..
Human  1606 AAGAASGEKKNSSQSLMVPQSGSPEPESIR-NTSRSSTPAIFASDPATCPIIPGCETTIEISKGR 1669

  Fly   906 V-IGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQNPASC-------GQQV----GATLA 958
            . :||              .|...|.|:...::|... ::..|:|       |.|:    |..|.
Human  1670 TGLGL--------------SIVGGSDTLLGAIIIHEV-YEEGAACKDGRLWAGDQILEVNGIDLR 1719

  Fly   959 DLRH----NYLQERLQMLFHHTTLVAPRDRYAQELV--EIEMDLASECHPGPLISLIDKAPQNHV 1017
            ...|    |.|::..|.:  ..||......|.:|.|  .:.::|..:...|..:|::.|.....|
Human  1720 KATHDEAINVLRQTPQRV--RLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGV 1782

  Fly  1018 VRSS--QRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDREHHSLLRKC--------- 1071
            ..|.  :..:.:.|.|    |:..:.|...:.:|.       ....:|..:.|.||
Human  1783 FVSDIVKGGIADADGR----LMQGDQILMVNGEDV-------RNATQEAVAALLKCSLGTVTLEV 1836

  Fly  1072 ----AGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVS------------------LLQD 1114
                |||                      .||...|...:.||                  .|:.
Human  1837 GRIKAGP----------------------FHSERRPSQSSQVSEGSLSSFTFPLSGSSTSESLES 1879

  Fly  1115 SSRE-----EINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQV 1174
            ||::     ||..|....:.:|....:.. |.||..|: .|..|..........||...:..|:|
Human  1880 SSKKNALASEIQGLRTVEMKKGPTDSLGI-SIAGGVGS-PLGDVPIFIAMMHPTGVAAQTQKLRV 1942

  Fly  1175 KFTVDGIIDTLRRTGTHFVHCYLLQHNAGK-HTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLR 1238
            ...:..|..|.....||.....||::.:|. ..:..|.|..|...|.   ::|..:..|..:.|.
Human  1943 GDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGH---QQEPASSSLSFTGLT 2004

  Fly  1239 GSQVLEAARLHRLGFPE--SVPL--------LEFVRRFGLLAGDL-----------ASNKDVSV- 1281
            .|.:.:    ..||.|:  |:.|        ...|..:|...|||           |:::|..:
Human  2005 SSSIFQ----DDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLK 2065

  Fly  1282 --EQILAVN 1288
              :||:|||
Human  2066 RGDQIIAVN 2074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	22/90 (24%)
		MYSc	556..1317	CDD:214580	181/873 (21%)
		MYSc_Myo18	575..1305	CDD:276837	178/854 (21%)
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
MPDZ	NP_001362342.1	PDZ_signaling	2019..2102	CDD:238492	14/56 (25%)
		L27_2	6..63	CDD:312549
		PDZ_signaling	139..221	CDD:238492
		PDZ_signaling	257..334	CDD:238492
		PDZ	374..463	CDD:214570
		PDZ_signaling	560..629	CDD:238492
		PDZ_signaling	698..784	CDD:238492
		PDZ_signaling	1006..1076	CDD:238492	13/75 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1140		5/18 (28%)
		PDZ_signaling	1149..1240	CDD:238492	24/94 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1278..1324		12/90 (13%)
		PDZ	1347..1433	CDD:214570	24/107 (22%)
		PDZ_signaling	1514..1593	CDD:238492	17/79 (22%)
		MPDZ_u10	1595..1659	CDD:374710	15/64 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1600..1645		13/45 (29%)
		PDZ	1660..1744	CDD:214570	20/100 (20%)
		PDZ_signaling	1758..1836	CDD:238492	15/88 (17%)
		PDZ_signaling	1893..1978	CDD:238492	19/86 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900