Protein Alignment Mhcl and myh9b

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_001427874.1
• Gene: myh9b / 561431
• ZFINID: ZDB-GENE-030131-998
• Length: 1960
• Species: Danio rerio
• Alignment Length: 1899
• Identity: 504/1899 - (26%)
• Similarity: 828/1899 - (43%)
• Gaps: 416/1899 - (21%)

  Fly   499 ADASQPERVWL-VHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDL 562
            ||.:..:.||: ..|.||.|      .|...:..:::.:.|..:|:::.|::||::|.|.|....
Zfish    22 ADWATKKLVWVPSERLGFEA------GSLKEEHGDEVVVELADSGKKIRVNKDDIQKMNPPKFSK 80

  Fly   563 VEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMP 627
            |||:.||..||||||||.|::||.|.||:|.:|...:|:||...|.:|||::|.|::|.|..:||
Zfish    81 VEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVDMYKGKKRHEMP 145

  Fly   628 PHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNN--------FINA 684
            ||:|::..|||||:::.|.|||::..|.||:||:.:.|..:.|||..|.::..        ..:.
Zfish   146 PHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKTKKDQSSSVLSHG 210

  Fly   685 EKVNALC---TILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGH 746
            |....|.   .|||||||.||..|.|::|..:.:.::||..|.|..|:::..|.|:.||.|:...
Zfish   211 ELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKE 275

  Fly   747 EHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNID 811
            |.:||:...:|.|....|:.||.||..   :.:.|:|.........:..:.::.||:|...:...
Zfish   276 ERTFHMFYYMLTGVGDKLRSELCLEGY---NKYRFLSNGNVTIPGQQDRDMYVETVEAMRIMGFS 337

  Fly   812 AKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQP 876
            .:...|:..:::::..||.....|  ...:.:....:.|||:|...|:|:|:.|.:.|   :..|
Zfish   338 EEEHVGLLRVISSVLQLGNMSFKK--ERHSDQASMPDDTAAQKVCHLMGMNVTDFTRA---ILSP 397

  Fly   877 NAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIAS-IMLIDT 940
            ....|.....|:.|.:.. |:|   :|||....|......:|..||:.:..:....|| |.::|.
Zfish   398 RIKVGRDYVQKAQTQEQA-EFA---VEALAKATYERMFRWLVMRINKALDKTKRQGASFIGILDI 458

  Fly   941 PGFQ----NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDL 996
            .||:    |          :...|..||..|:||.||:||..:..::.|.:|     .::..:||
Zfish   459 AGFEIFELN----------SFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWSFIDFGLDL 513

  Fly   997 ASECHPGPLISLIDK--APQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHY 1059
            .      |.|.||:|  :|.                 |:|.|||||..:|.:.|.:|:|::....
Zfish   514 Q------PCIDLIEKPASPP-----------------GILALLDEECWFPKATDKSFVEKVLQEQ 555

  Fly  1060 GDREHHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLY 1124
            |........:|......|.:.|..|  .|.|..|.|:..:.: |...|..:||..|:...::.|:
Zfish   556 GTHPKFHKPKKLKDEADFCIIHYAG--KVDYKADEWLMKNMD-PLNDNVATLLNQSTDRFVSELW 617

  Fly  1125 -----IGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQV-KFTVDGIID 1183
                 |..|.:.:|.....|:|...:|            .|.|.|        |: |..:..::.
Zfish   618 KDVDRIVGLDKVAGMSELPGAFKTRKG------------MFRTVG--------QLYKEQLSKLMA 662

  Fly  1184 TLRRTGTHFVHCYLLQH--NAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAA 1246
            |||.|..:||.|.:..|  .|||                       ::..|:..|||.:.|||..
Zfish   663 TLRNTNPNFVRCIIPNHEKKAGK-----------------------LDPHLVLDQLRCNGVLEGI 704

  Fly  1247 RLHRLGFPESVPLLEFVRRFGLLAGD-----LASNKDVSVEQILAVNELDVASYRIGPSQILFRS 1306
            |:.|.|||..:...||.:|:.:|..:     ....|...:..|.|: |||...||||.|::.||:
Zfish   705 RICRQGFPNRIVFQEFRQRYEILTPNSIPKGFMDGKQACMLMIRAL-ELDPNLYRIGQSKVFFRA 768

  Fly  1307 GVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRL 1371
            |||:.||.:||:.::|.||..||:||||:|||..::|:.|..|:|.||||..|:|.:|:|.||||
Zfish   769 GVLAHLEEERDMKITDVIINFQAWCRGYVARKAFAKRQQQLTAMRVIQRNCAAYLKLRNWQWWRL 833

  Fly  1372 LVRVTPLLNVHRTEEQLKTANEELLMLRAK-------------------LEKI------------ 1405
            ..:|.|||.|.|.||:::...|||..:|.|                   .||:
Zfish   834 FTKVKPLLQVSRQEEEMQAKEEELSKVREKQQVAEQQLVEMEVKQQQLNAEKMALQEQLQAEMDL 898

  Fly  1406 --ECD--RSEVKAENQKLEAKLSELTVDLAEERSTA-HIATER-------------LEAETAERL 1452
              |.|  |:.:.|:.|:||..|.:|...:.||...| |:..|:             |:.|.|.|.
Zfish   899 CAEADEMRNRLVAKKQELEEILHDLEARVEEEEERANHLQAEKKKMQQNIADLEQQLDEEEAARQ 963

  Fly  1453 KLEKE-----------------LGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENEDG 1500
            ||:.|                 |.||.||:     :.||..||...|:...|...|:|.:::...
Zfish   964 KLQLEKVTMEAKLKKTEEEVMVLDDQNNKL-----SKEKKLMEERIAEFTTNLAEEEEKSKSLQK 1023

  Fly  1501 VGGGVYKLKYERVARELEFTKRRLHTQHEHDLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQWKR 1565
            :     |.|:|.:..:||...||    .|...::|...::.||...::.::::.|.:..:.:.|.
Zfish  1024 L-----KNKHEAMITDLEDRLRR----EEKQRQELEKNRRKLEGDSTELHDQIAELQAQIAELKA 1079

  Fly  1566 KAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAK---ERYGRE-KDVL 1626
            :..|...|:.:....:||:.|:.||.:||.|:.:::...||:.:..||.|:   |::.|: .:.|
Zfish  1080 QLAKKEEELQEALARIEEEAAQKNLAQKKIRELESQLSELQEDLELERAARTKAEKHRRDLGEEL 1144

  Fly  1627 QAEKFTLEQTLADTRLDLEF---KEEKLASLQRELEE-----------------MTFGGGTEEEF 1671
            :|.|..||.||..|....|.   :|.::|.|::.|||                 ..| ....|:.
Zfish  1145 EALKTELEDTLDSTAAQQELRTKRETEVAQLKKALEEDAKVHEQVMAEIRQKHSQAF-DELNEQL 1208

  Fly  1672 AQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAK-------LRLEMTLETMRKEARRESQQRDE 1729
            .|::|:|...|:..:..|.|.:|:..::|.|.|.|       .:.|..|:.::.:.....:||.|
Zfish  1209 EQVKRNKVSVEKSKQALESERNELQIELQTLMQGKGESEHRRKKAEAQLQELQVKHTESERQRIE 1273

  Fly  1730 ----------ELEEVR-----GNGYKKIKA------LECQLETEHEERTLLLREKHELERRLSSM 1773
                      ||:.|.     ..| |.|||      :|.||:...|......|:|..|..||..:
Zfish  1274 LAERLTKMQAELDNVNTLLSDAEG-KSIKASKDCSTVESQLQDVQEVLQEETRQKLSLNTRLRQL 1337

  Fly  1774 EDRD---RVDRDAEEALNQKLRRDLRKYKALLKDAQTQLERLKADTPGKTLIRQLRNQLEDAESA 1835
            ||..   |...:.||...:.|.:.:...:|.|.|.:.::|             |....||.||.:
Zfish  1338 EDEQHSLREQLEEEEEAKRNLEKQIGTMQAQLVDMKKKME-------------QESGSLECAEES 1389

  Fly  1836 RSLAMKARQTAEAELTEVQAMFDESHRARND---------------------------------A 1867
            |....:..:.....|.|..|.||:..:.:..                                 |
Zfish  1390 RKRVQRDLEAVSQRLDERNAAFDKLDKTKTRLQQELDDMLVDQDHLRQIVSNLEKKQKKFDQMLA 1454

  Fly  1868 EERANAA----HRDRAELQAQIEEN---------------EEELGELMKKYSATVKQLNTEQINV 1913
            ||::.:|    .|||||.:|:.:|.               :|||....|...|.::.|.:.:.:|
Zfish  1455 EEKSISARYAEERDRAEAEAREKETRMLALARELETLTDMKEELDRTNKLLRAEMEDLVSSKDDV 1519

  Fly  1914 SEAEFKLNE----MEAERNNLKEQVAELQHRLDNVEN-------------------------LGD 1949
            .::...|.:    ||.:...:|.|:.||:..|...|:                         ||:
Zfish  1520 GKSVHDLEKSKRAMEQQLEEMKTQLEELEDELQATEDAKLRLEVNMQAMKAQYERDLQGRDELGE 1584

  Fly  1950 PSMAMMSKRLELRTKELESRLE-------LEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQ 2007
            .....:.|::    :|:|..||       |..|.|.::|:.       |::|:..:.|:.....:
Zfish  1585 EKKRQLLKQV----REMEMELEDERKQRTLAMAARKKMELD-------LKELEAAIDQANKNRDE 1638

  Fly  2008 AQDVIKKSQKSLRDMREEFHAVSSREQESLTRRKDLEKKVEQMESEGAALKNDL-------RLAL 2065
            |...:||.|..::|:..|........:|.|.:.|:.||||:.||:|...::.:|       |.|.
Zfish  1639 ALKQLKKVQAQMKDLLRELEDTRLSREEILAQSKENEKKVKSMEAEMIQMQEELAAAERAKRQAQ 1703

  Fly  2066 QRIADLQQAMEEE------GEEE-------LSESDESLSSVGSISDL-EDRLR-----------P 2105
            |...:||..:..:      |.||       :::.:|.|....:.::| .|||:           .
Zfish  1704 QERDELQDEINNQAAKGALGSEERRRLEARIAQLEEELEEEQNNTELVNDRLKRALLQTDQMNVE 1768

  Fly  2106 VHVKRSSQQSLNGS 2119
            :..:||:.|.|.|:
Zfish  1769 LTAERSTSQRLEGA 1782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	462/1722 (27%)
		MYSc_Myo18	575..1305	CDD:276837	215/765 (28%)
myh9b	NP_001427874.1	None