DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and myh9b

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:XP_001920098.4 Gene:myh9b / 561431 ZFINID:ZDB-GENE-030131-998 Length:1698 Species:Danio rerio


Alignment Length:1797 Identity:491/1797 - (27%)
Similarity:828/1797 - (46%) Gaps:336/1797 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   499 ADASQPERVWL-VHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDL 562
            ||.:..:.||: ..|.||.|      .|...:..:::.:.|..:|:::.|::||::|.|.|....
Zfish    22 ADWATKKLVWVPSERLGFEA------GSLKEEHGDEVVVELADSGKKIRVNKDDIQKMNPPKFSK 80

  Fly   563 VEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMP 627
            |||:.||..||||||||.|::||.|.||:|.:|...:|:||...|.:|||::|.|::|.|..:||
Zfish    81 VEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVDMYKGKKRHEMP 145

  Fly   628 PHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNN--------FINA 684
            ||:|::..|||||:::.|.|||::..|.||:||:.:.|..:.|||..|.::..        ..:.
Zfish   146 PHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKTKKDQSSSVLSHG 210

  Fly   685 EKVNALC---TILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGH 746
            |....|.   .|||||||.||..|.|::|..:.:.::||..|.|..|:::..|.|:.||.|:...
Zfish   211 ELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKE 275

  Fly   747 EHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNID 811
            |.:||:...:|.|....|:.||.||..   :.:.|:|.........:..:.::.||:|...:...
Zfish   276 ERTFHMFYYMLTGVGDKLRSELCLEGY---NKYRFLSNGNVTIPGQQDRDMYVETVEAMRIMGFS 337

  Fly   812 AKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQP 876
            .:...|:..:::::..||.....|  ...:.:....:.|||:|...|:|:|:.|.:.|   :..|
Zfish   338 EEEHVGLLRVISSVLQLGNMSFKK--ERHSDQASMPDDTAAQKVCHLMGMNVTDFTRA---ILSP 397

  Fly   877 NAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIAS-IMLIDT 940
            ....|.....|:.|.:.. |:|   :|||....|......:|..||:.:..:....|| |.::|.
Zfish   398 RIKVGRDYVQKAQTQEQA-EFA---VEALAKATYERMFRWLVMRINKALDKTKRQGASFIGILDI 458

  Fly   941 PGFQ----NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDL 996
            .||:    |          :...|..||..|:||.||:||..:..::.|.:|     .::..:||
Zfish   459 AGFEIFELN----------SFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWSFIDFGLDL 513

  Fly   997 ASECHPGPLISLIDK--APQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHY 1059
            .      |.|.||:|  :|.                 |:|.|||||..:|.:.|.:|:|::....
Zfish   514 Q------PCIDLIEKPASPP-----------------GILALLDEECWFPKATDKSFVEKVLQEQ 555

  Fly  1060 GDREHHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLY 1124
            |........:|......|.:.|..|  .|.|..|.|:..:.: |...|..:||..|:...::.|:
Zfish   556 GTHPKFHKPKKLKDEADFCIIHYAG--KVDYKADEWLMKNMD-PLNDNVATLLNQSTDRFVSELW 617

  Fly  1125 -----IGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQV-KFTVDGIID 1183
                 |..|.:.:|.....|:|...:|            .|.|.|        |: |..:..::.
Zfish   618 KDVDRIVGLDKVAGMSELPGAFKTRKG------------MFRTVG--------QLYKEQLSKLMA 662

  Fly  1184 TLRRTGTHFVHCYLLQH--NAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAA 1246
            |||.|..:||.|.:..|  .|||                       ::..|:..|||.:.|||..
Zfish   663 TLRNTNPNFVRCIIPNHEKKAGK-----------------------LDPHLVLDQLRCNGVLEGI 704

  Fly  1247 RLHRLGFPESVPLLEFVRRFGLLAGD-----LASNKDVSVEQILAVNELDVASYRIGPSQILFRS 1306
            |:.|.|||..:...||.:|:.:|..:     ....|...:..|.|: |||...||||.|::.||:
Zfish   705 RICRQGFPNRIVFQEFRQRYEILTPNSIPKGFMDGKQACMLMIRAL-ELDPNLYRIGQSKVFFRA 768

  Fly  1307 GVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRL 1371
            |||:.||.:||:.::|.||..||:||||:|||..::|:.|..|:|.||||..|:|.:|:|.||||
Zfish   769 GVLAHLEEERDMKITDVIINFQAWCRGYVARKAFAKRQQQLTAMRVIQRNCAAYLKLRNWQWWRL 833

  Fly  1372 LVRVTPLLNVHRTEEQLKTANEELLMLRAK-------------------LEKI------------ 1405
            ..:|.|||.|.|.||:::...|||..:|.|                   .||:            
Zfish   834 FTKVKPLLQVSRQEEEMQAKEEELSKVREKQQVAEQQLVEMEVKQQQLNAEKMALQEQLQAEMDL 898

  Fly  1406 --ECD--RSEVKAENQKLEAKLSELTVDLAEERSTA-HIATER-------------LEAETAERL 1452
              |.|  |:.:.|:.|:||..|.:|...:.||...| |:..|:             |:.|.|.|.
Zfish   899 CAEADEMRNRLVAKKQELEEILHDLEARVEEEEERANHLQAEKKKMQQNIADLEQQLDEEEAARQ 963

  Fly  1453 KLEKE-----------------LGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENEDG 1500
            ||:.|                 |.||.||:     :.||..||...|:...|...|:|.:::...
Zfish   964 KLQLEKVTMEAKLKKTEEEVMVLDDQNNKL-----SKEKKLMEERIAEFTTNLAEEEEKSKSLQK 1023

  Fly  1501 VGGGVYKLKYERVARELEFTKRRLHTQHEHDLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQWKR 1565
            :     |.|:|.:..:||...||    .|...::|...::.||...::.::::.|.:..:.:.|.
Zfish  1024 L-----KNKHEAMITDLEDRLRR----EEKQRQELEKNRRKLEGDSTELHDQIAELQAQIAELKA 1079

  Fly  1566 KAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAK---ERYGRE-KDVL 1626
            :..|...|:.:....:||:.|:.||.:||.|:.:::...||:.:..||.|:   |::.|: .:.|
Zfish  1080 QLAKKEEELQEALARIEEEAAQKNLAQKKIRELESQLSELQEDLELERAARTKAEKHRRDLGEEL 1144

  Fly  1627 QAEKFTLEQTLADTRLDLEF---KEEKLASLQRELEEMTFGGGTEEEFAQLRRSKNETERRAKEQ 1688
            :|.|..||.||..|....|.   :|.::|.|::.|||  .....|:..|::|          ::.
Zfish  1145 EALKTELEDTLDSTAAQQELRTKRETEVAQLKKALEE--DAKVHEQVMAEIR----------QKH 1197

  Fly  1689 EEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKKIKALECQLETEH 1753
            .:..||:..|::.:::.|:.:|.:.:.:..| |.|.|...:.|.:.:|....:.|..|.||:...
Zfish  1198 SQAFDELNEQLEQVKRNKVSVEKSKQALESE-RNELQIELQTLMQGKGESEHRRKKAEAQLQELQ 1261

  Fly  1754 EERTLLLREKHELERRLSSME-DRDRVD---RDAEEALNQKLRRDLRKYKALLKDAQTQLERLKA 1814
            .:.|...|::.||..||:.|: :.|.|:   .|| |..:.|..:|....::.|:|.|   |.|:.
Zfish  1262 VKHTESERQRIELAERLTKMQAELDNVNTLLSDA-EGKSIKASKDCSTVESQLQDVQ---EVLQE 1322

  Fly  1815 DTPGK----TLIRQ-------LRNQLEDAESARSLAMKARQTAEAELTEVQAMFDESHRARNDAE 1868
            :|..|    |.:||       ||.|||:.|.|:....|...|.:|:|.:::...::...:...||
Zfish  1323 ETRQKLALNTRLRQLEDEQHSLREQLEEEEEAKRNLEKQIGTMQAQLVDMKKKMEQESGSLECAE 1387

  Fly  1869 ERANAAHRDRAELQAQIEEN--------------EEELGELMKKYSATVKQLNTEQI--NVSEAE 1917
            |......||...:..:::|.              ::||.:::      |.|.:..||  |:.:.:
Zfish  1388 ESRKRVQRDLEAVSQRLDERNAAFDKLDKTKTRLQQELDDML------VDQDHLRQIVSNLEKKQ 1446

  Fly  1918 FKLNEMEAERNNLKEQVAELQHRLDNVENLGDPSMAMMSKRLELRT----------KELESRLE- 1971
            .|.::|.||..::..:.||.:.|.:......:..|..:::.||..|          |.|.:.:| 
Zfish  1447 KKFDQMLAEEKSISARYAEERDRAEAEAREKETRMLALARELETLTDMKEELDRTNKLLRAEMED 1511

  Fly  1972 --------------LEQATRARLEVQVNRHKEALEKLQNEVTQSK-----------------MRE 2005
                          ||::.|| :|.|:...|..||:|::|:..::                 .|:
Zfish  1512 LVSSKDDVGKSVHDLEKSKRA-MEQQLEEMKTQLEELEDELQATEDAKLRLEVNMQAMKAQYERD 1575

  Fly  2006 MQAQDVI--KKSQKSLRDMRE-EFHAVSSREQESL--TRRKDLEKKVEQME--------SEGAAL 2057
            :|.:|.:  :|.::.|:.:|| |......|:|.:|  ..||.:|..::::|        :...||
Zfish  1576 LQGRDELGEEKKRQLLKQVREMEMELEDERKQRTLAMAARKKMELDLKELEAAIDQANKNRDEAL 1640

  Fly  2058 KNDLRLALQRIADLQQAMEE---EGEEELSESDESLSSVGSI 2096
            | .|:....::.||.:.:|:   ..||.|::|.|:...|.|:
Zfish  1641 K-QLKKVQAQMKDLLRELEDTRLSREEILAQSKENEKKVKSM 1681

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 232/796 (29%)
MYSc_Myo18 575..1305 CDD:276837 215/765 (28%)
GBP_C <1540..1750 CDD:303769 53/216 (25%)
COG1340 1565..1833 CDD:224259 79/289 (27%)
coiled coil 1723..1734 CDD:293879 3/10 (30%)
myh9bXP_001920098.4 Myosin_N 28..66 CDD:280832 9/43 (21%)
Myosin_head 81..767 CDD:278492 223/777 (29%)
Motor_domain 93..767 CDD:277568 215/765 (28%)
KASH_CCD 937..1120 CDD:291334 44/196 (22%)
Sec1 <943..>1076 CDD:301618 32/146 (22%)
Dor1 1018..>1175 CDD:302817 41/165 (25%)
Filament 1034..1341 CDD:278467 84/327 (26%)
Rab5-bind 1306..1606 CDD:286404 67/309 (22%)
GrpE 1532..>1640 CDD:295646 23/108 (21%)
GBP_C <1596..1689 CDD:303769 23/87 (26%)
coiled coil 1660..1669 CDD:293879 2/8 (25%)
coiled coil 1678..1689 CDD:293879 2/4 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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