DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhcl and MYO10

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_036466.2 Gene:MYO10 / 4651 HGNCID:7593 Length:2058 Species:Homo sapiens


Alignment Length:1852 Identity:392/1852 - (21%)
Similarity:706/1852 - (38%) Gaps:473/1852 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   506 RVWLVHRG-GFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPAL-----DLVE 564
            ||||...| .|.:.:.  :.:.|      :.:.....|:..|..:..:..|...|:     :.|:
Human    10 RVWLRENGQHFPSTVN--SCAEG------IVVFRTDYGQVFTYKQSTITHQKVTAMHPTNEEGVD 66

  Fly   565 DICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLS-LYSEKVVSMFRGCKTEDMPP 628
            |:..|..|:..|:::.|.|||..|.|:|..|..|..|||..|:: ||....:..:......::||
Human    67 DMASLTELHGGSIMYNLFQRYKRNQIYTYIGSILASVNPYQPIAGLYEPATMEQYSRRHLGELPP 131

  Fly   629 HVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNAL--- 690
            |::::|...||.|.:...:|.::..|.||:||:.|.|..|.:|::.:.........||.:.:   
Human   132 HIFAIANECYRCLWKRHDNQCILISGESGAGKTESTKLILKFLSVISQQSLELSLKEKTSCVERA 196

  Fly   691 ----CTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFH 751
                ..|:|||||.||..|:|::|..:.:.|:..|.|.|....:...|.|:.|..|:...|.::|
Human   197 ILESSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKGNIQGGRIVDYLLEKNRVVRQNPGERNYH 261

  Fly   752 IMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAAND-FMRTVQAFETLNIDAKAV 815
            |...||||.....::|.:|.  |.|:.| :::.|..:||:..:..: |...:.|.:.:....:.|
Human   262 IFYALLAGLEHEEREEFYLS--TPENYH-YLNQSGCVEDKTISDQESFREVITAMDVMQFSKEEV 323

  Fly   816 RGIWSILAAIYHLG-IAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQPNAP 879
            |.:..:||.|.||| |..:|..|      .|.:..||..:::.|||::...|:.|   |||.:..
Human   324 REVSRLLAGILHLGNIEFITAGG------AQVSFKTALGRSAELLGLDPTQLTDA---LTQRSMF 379

  Fly   880 NGG---LSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTP 941
            ..|   |:|       ...:.|.:..::|.:.||:.....|:..||.:| ..:....||.::|..
Human   380 LRGEEILTP-------LNVQQAVDSRDSLAMALYACCFEWVIKKINSRI-KGNEDFKSIGILDIF 436

  Fly   942 GFQNPASCGQQVGATLADLRH------NYLQERLQMLFHHTTLVAPRDRYAQE-LVEIEMDLASE 999
            ||:|            .::.|      ||..|:||..|:.......:..|::| ||..::|....
Human   437 GFEN------------FEVNHFEQFNINYANEKLQEYFNKHIFSLEQLEYSREGLVWEDIDWIDN 489

  Fly  1000 CHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDREH 1064
               |..:.||:|                  :.|:|.|::||:.:|.:.|.|.||:|.|.:.:  :
Human   490 ---GECLDLIEK------------------KLGLLALINEESHFPQATDSTLLEKLHSQHAN--N 531

  Fly  1065 HSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIR-NAVSLLQDSSREEINRLYIGSL 1128
            |..::.......|.:.|..|  .|.|.|.|.:..:|:  ..| :.::||::|..:.|..|:....
Human   532 HFYVKPRVAVNNFGVKHYAG--EVQYDVRGILEKNRD--TFRDDLLNLLRESRFDFIYDLFEHVS 592

  Fly  1129 TRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFV 1193
            :|.:...:.|||                       ..:|.::..|.|.::..::.||..:...||
Human   593 SRNNQDTLKCGS-----------------------KHRRPTVSSQFKDSLHSLMATLSSSNPFFV 634

  Fly  1194 HCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVP 1258
            .|  ::.|..|                   ..:..:..::.:|||.|.:||..|:.:.|:....|
Human   635 RC--IKPNMQK-------------------MPDQFDQAVVLNQLRYSGMLETVRIRKAGYAVRRP 678

  Fly  1259 LLEFVRRFGLLAGDLASNKDV--SVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLS 1321
            ..:|.:|:.:|..:||..:||  ....:|.:.:...:.:::|.:::..|..:..:||.:|:..:|
Human   679 FQDFYKRYKVLMRNLALPEDVRGKCTSLLQLYDASNSEWQLGKTKVFLRESLEQKLEKRREEEVS 743

  Fly  1322 DRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWR-------------LLV 1373
            ...:.::|...|:||||   |.|.....|..||:|.:|||..|.:...:             :..
Human   744 HAAMVIRAHVLGFLARK---QYRKVLYCVVIIQKNYRAFLLRRRFLHLKKAAIVFQKQLRGQIAR 805

  Fly  1374 RVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAE-----------NQKLEA-----K 1422
            ||...|...:.|::.|...||....:.:.|:.|.:|...:||           .|:|||     |
Human   806 RVYRQLLAEKREQEEKKKQEEEEKKKREEEERERERERREAELRAQQEEETRKQQELEALQKSQK 870

  Fly  1423 LSELTVDLAEERSTAHIATERLEAETAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLN 1487
            .:|||.:|.:::....:         .|.|:||||:.|       ||...|:.|:.|  .::.|.
Human   871 EAELTRELEKQKENKQV---------EEILRLEKEIED-------LQRMKEQQELSL--TEASLQ 917

  Fly  1488 GISEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQHEHDLEQLVALKKHLEMKLSDAYEE 1552
            .:.|..|.|        :.:|:.|......||    |.:.:..::::.|   :::|..||     
Human   918 KLQERRDQE--------LRRLEEEACRAAQEF----LESLNFDEIDECV---RNIERSLS----- 962

  Fly  1553 VVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKE 1617
                   ||      .:.::|:.:  ...||:...|......:.:.|...::..||.:......|
Human   963 -------VG------SEFSSELAE--SACEEKPNFNFSQPYPEEEVDEGFEADDDAFKDSPNPSE 1012

  Fly  1618 RYG---------REKDVLQAEKFTLEQTL------ADTRLDLEFKEEKLASL------------- 1654
             :|         |..|....|...:..|:      ||:.:.|....:...||             
Human  1013 -HGHSDQRTSGIRTSDDSSEEDPYMNDTVVPTSPSADSTVLLAPSVQDSGSLHNSSSGESTYCMP 1076

  Fly  1655 ----------------QRELEE--------MTFGG--------------GTEEEFAQLRRSKNET 1681
                            |.:.|:        :||..              ||.......|.|....
Human  1077 QNAGDLPSPDGDYDYDQDDYEDGAITSGSSVTFSNSYGSQWSPDYRCSVGTYNSSGAYRFSSEGA 1141

  Fly  1682 ERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKKI---- 1742
            :...::.||:.|.             |.:                .|:||...|.:.|..:    
Human  1142 QSSFEDSEEDFDS-------------RFD----------------TDDELSYRRDSVYSCVTLPY 1177

  Fly  1743 ---------------KALECQLETEHEERTLLLREKHELERR------------LSSMEDRDR-- 1778
                           |...|.|:   :|..|..|.|.|..::            ||....:.|  
Human  1178 FHSFLYMKGGLMNSWKRRWCVLK---DETFLWFRSKQEALKQGWLHKKGGGSSTLSRRNWKKRWF 1239

  Fly  1779 ---------VDRDAEEALNQKLRRDLRKYKALLKDA--QTQLERLKADTPGKTLIRQLRNQLEDA 1832
                     .:.|:||.|...:  ::|..|.::.:.  :..::.:.||    .....:....|||
Human  1240 VLRQSKLMYFENDSEEKLKGTV--EVRTAKEIIDNTTKENGIDIIMAD----RTFHLIAESPEDA 1298

  Fly  1833 ESARSLAMKARQTAEAELTEVQAMFDESHRARN----------------DAEERANA-----AHR 1876
            ....|:..:...:.:   .|:|.|.||....:|                |:.:|.|:     |:|
Human  1299 SQWFSVLSQVHASTD---QEIQEMHDEQANPQNAVGTLDVGLIDSVCASDSPDRPNSFVIITANR 1360

  Fly  1877 DRAELQAQIEENEEELGELMKKYSATVKQLNTEQINVSEAEFKL---------NEMEAERNNLKE 1932
               .|....:..||      ..:..|:.|.:.....|...||.:         |..:.....||:
Human  1361 ---VLHCNADTPEE------MHHWITLLQRSKGDTRVEGQEFIVRGWLHKEVKNSPKMSSLKLKK 1416

  Fly  1933 QVAELQHRLDNVENLGDPSMAMMSKRLELRTKELESRLEL--------EQATRARLEVQVNRHKE 1989
            :...|.|      |..|...:.....|:|.|..|.|...:        ::.....:.|...:|..
Human  1417 RWFVLTH------NSLDYYKSSEKNALKLGTLVLNSLCSVVPPDEKIFKETGYWNVTVYGRKHCY 1475

  Fly  1990 AL-EKLQNEVTQSKMREMQAQD----VIKKSQKSLRDMREEFHAVSSREQESLTRRKDLEKKVEQ 2049
            .| .||.||.|:.........|    :...:|:.::|::|  :.::|...|.:.:|..:.:....
Human  1476 RLYTKLLNEATRWSSAIQNVTDTKAPIDTPTQQLIQDIKE--NCLNSDVVEQIYKRNPILRYTHH 1538

  Fly  2050 -MESEGAALK-NDLRLALQRIADLQQAMEEEGEEELSESDESLSSVGSISDLEDR---------- 2102
             :.|....|. .|:.|.|         ::::|...|  .||::....|:..||..          
Human  1539 PLHSPLLPLPYGDINLNL---------LKDKGYTTL--QDEAIKIFNSLQQLESMSDPIPIIQGI 1592

  Fly  2103 ------LRPVH-------VKRSSQQSLNGSIG 2121
                  |||:.       :|::::....||:|
Human  1593 LQTGHDLRPLRDELYCQLIKQTNKVPHPGSVG 1624

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 193/788 (24%)
MYSc_Myo18 575..1305 CDD:276837 185/752 (25%)
GBP_C <1540..1750 CDD:303769 42/294 (14%)
COG1340 1565..1833 CDD:224259 56/377 (15%)
coiled coil 1723..1734 CDD:293879 3/10 (30%)
MYO10NP_036466.2 MYSc 58..739 CDD:214580 192/783 (25%)
MYSc_Myo10 77..727 CDD:276840 185/752 (25%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 619..641 5/23 (22%)
SAH. /evidence=ECO:0000250|UniProtKB:F8VQB6, ECO:0000250|UniProtKB:P79114 815..908 28/108 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 819..840 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 847..866 5/18 (28%)
Mediates antiparallel dimerization. /evidence=ECO:0000269|PubMed:23012428 883..933 17/75 (23%)
MYO10_CC 883..933 CDD:293340 17/75 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1090 19/134 (14%)
PH-like 1181..>1223 CDD:302622 8/44 (18%)
PH2_MyoX 1215..1316 CDD:270108 15/109 (14%)
PH 1215..1308 CDD:278594 15/98 (15%)
PH3_MyoX-like 1381..1506 CDD:270109 24/130 (18%)
PH 1396..1495 CDD:278594 20/104 (19%)
MyTH4 1549..1695 CDD:214535 17/87 (20%)
B41 1704..1958 CDD:214604
UBQ 1705..>1753 CDD:294102
FERM_M 1796..1958 CDD:278785
FERM_C_MyoX 1954..2042 CDD:270023
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.