Protein Alignment Mhcl and MYH3

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_002461.2
• Gene: MYH3 / 4621
• HGNCID: 7573
• Length: 1940
• Species: Homo sapiens
• Alignment Length: 1954
• Identity: 481/1954 - (24%)
• Similarity: 813/1954 - (41%)
• Gaps: 494/1954 - (25%)

  Fly   530 EENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKA 594
            ::.|:::....| ..|.|..:||...|.|..|.:||:..|.:|||.:||:.|:.||.|.:|:|.:
Human    56 QDGKVTVETEDN-RTLVVKPEDVYAMNPPKFDRIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYS 119

  Fly   595 GPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSG 659
            |...:.|||...|.:|:.:||..:||.|.::.|||::|::..||:.::..|.:||::..|.||:|
Human   120 GLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAG 184

  Fly   660 KSTSFKHALNYLALAAGA---------------YNNFINAEKVNALCTILEAFGNTKTCLNSNAT 709
            |:.:.|..:.|.|..|..               .:..|:|.      .:||||||.||..|.|::
Human   185 KTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISAN------PLLEAFGNAKTVRNDNSS 243

  Fly   710 RMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENIT 774
            |..:.:.:.|..||::|||.::..|.|:.|...:|..|.|:||..::|:.....|.:.|.:  .|
Human   244 RFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLI--TT 306

  Fly   775 SEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTG 839
            :...:||||..:.|......|.:.:.|..|.:.|....:...|::.:..|:.|.|     .:...
Human   307 NPYDYPFISQGEILVASIDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYG-----NMKFK 366

  Fly   840 STARTQFANP---TAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWEC 901
            ...|.:.|.|   ..|.|.:.|:|:|..||..|   |..|....|....:|..|.|..|    ..
Human   367 QKQREEQAEPDGTEVADKTAYLMGLNSSDLLKA---LCFPRVKVGNEYVTKGQTVDQVH----HA 424

  Fly   902 LEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRH 962
            :.||...:|.:....:|..||:|:.|.......|.::|..||:    |          :|..|..
Human   425 VNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYN----------SLEQLCI 479

  Fly   963 NYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQ 1022
            |:..|:||..|:|...|..::.|.:|     .::..||||: |     |.||:|.
Human   480 NFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAA-C-----IELIEKP---------- 528

  Fly  1023 RDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAGPRQ--FVLHHLQG 1084
                    .|:..:|:||.::|.:.|.:|..:|: .|.|...:....:...|..:  |.|.|..|
Human   529 --------MGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHFSLIHYAG 585

  Fly  1085 TNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQS 1149
            |  |.|:|.||:..::: |.....|.|.|.||...:..||              .:||..:....
Human   586 T--VDYSVSGWLEKNKD-PLNETVVGLYQKSSNRLLAHLY--------------ATFATADADSG 633

  Fly  1150 LRRVSSIR-RSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGS 1213
            .::|:..: .||.|       :....:..::.::..||.|..|||.|.:            .|.:
Human   634 KKKVAKKKGSSFQT-------VSALFRENLNKLMSNLRTTHPHFVRCII------------PNET 679

  Fly  1214 PSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL------AGD 1272
            .:..|.:.|         |:..|||.:.|||..|:.|.|||..:...:|.:|:.:|      .|.
Human   680 KTPGAMEHS---------LVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQ 735

  Fly  1273 LASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLAR 1337
            ...:|. :.|::||..::|...|:.|.:::.|::|:|..||..||..|:..|.:.||.|||:|.|
Human   736 FIDSKK-ACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDDRLAKLITRTQAVCRGFLMR 799

  Fly  1338 ---KKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLR 1399
               :||.|||.   ::.|||.|:::|:.|:.|||.:|..::.|||....||:::.|..||....:
Human   800 VEFQKMVQRRE---SIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTK 861

  Fly  1400 AKLEKIECDRSE------------------VKAENQ-----------------KLEAKLSELTVD 1429
            .:|.|.|..|.|                  |:||::                 :||||:.|:| :
Human   862 DELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVT-E 925

  Fly  1430 LAEERSTAHIATERLEAE-TAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDE 1493
            .||:.       |.:.|| ||::.|||.|..:....:.:|:.|..|:|.|....::.:..::|:
Human   926 RAEDE-------EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE- 982

  Fly  1494 DAENEDGVGGGVYKLKYERVA-------------------RELEFTKRRLHTQHEHDLE------ 1533
                ..|:...:.||..|:.|                   ..|..||.:|..|.| |||
Human   983 ----LSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVE-DLESSLEQE 1042

  Fly  1534 -----QLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEK 1593
                 .|...|:.||..|..|.|.:::......|...:.:|...|...|:..:|::.......:|
Human  1043 KKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQK 1107

  Fly  1594 KQRKFDAECQSLQDAVRQERQAKER-------YGREKDVLQAEKFTLEQTLADTRLDLEFKEE-K 1650
            |.::..|..:.|::.:..||..:.:       |.||.:.| :|:......:..|:::|..|.| :
Human  1108 KIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEEL-SERLEEAGGVTSTQIELNKKREAE 1171

  Fly  1651 LASLQRELEEMTFG----------------GGTEEEFAQLRRSKNETERRAKEQEEELDEMAGQI 1699
            ...|:|:|||.|..                ....|:...|:|.|.:.|:...|.:.|:|:::..:
Human  1172 FLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSM 1236

  Fly  1700 QLLEQAKLRLE---MTLETMRKEARRESQQRDEELEEVRGNGYK--------------------- 1740
            :.:.::|..||   .|||....|||.::::....|.|:.....:
Human  1237 ESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQ 1301

  Fly  1741 ----------KIKALECQLETEHEERTL-------------LLRE--------KHELERRLSSME 1774
                      :.:.|:.|||.|::.:..             ||||        |.||:|.||...
Human  1302 LSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKAN 1366

  Fly  1775 ----------DRDRVDR----------------DAEE---------------------------- 1785
                      :.|.:.|                |:||
Human  1367 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMV 1431

  Fly  1786 ----------ALNQKLR---RDLRKYKALLKDAQTQLE-RLKADTPGKTLIRQLRNQLED----- 1831
                      ||::|.|   :.|.::|...:::|.:|| .||......|.:.:|:|..|:
Human  1432 DVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQL 1496

  Fly  1832 ---------------------AESARSL--AMKARQTAEAELTEVQAMFDESHRARNDAEERANA 1873
                                 ||:.:::  ..|:|:..|.|..::|...:|:..|....|.:...
Human  1497 ETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILR 1561

  Fly  1874 AHRD----RAELQAQIEENEEELGELMKKYSATVK----QLNTEQINVSEA-------EFKLNEM 1923
            ...:    ::|:..:|.|.:||:.:|.:.|..||:    .|:.|..:.:||       |..|||:
Human  1562 IQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEI 1626

  Fly  1924 EAERNNLKEQVAELQHRLDNVE--------NLGD---------PSMAMMSKRLELRTKELES-RL 1970
            |.:.::...|.||....|.:|:        :|.|         ..:|::.:|..|...|:|. |.
Human  1627 EIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRA 1691

  Fly  1971 ELEQATRAR----------------LEVQ---VNRHKEALE----KLQNEVTQSKMREMQAQDVI 2012
            .|||..|||                |..|   :...|:.||    :||:||..:......|::..
Human  1692 TLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKA 1756

  Fly  2013 KKSQKSLRDMREEFHAVSSREQES---LTR-RKDLEKKVEQM-----ESEGAAL---KNDLRLAL 2065
            ||:......|.||.    .:||::   |.| :|:||:.|:.:     |:|..||   |..::...
Human  1757 KKAITDAAMMAEEL----KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE 1817

  Fly  2066 QRIADLQQAMEEEGEE------------------ELS-ESDESLSSVGSISDLEDRLRPVHVKRS 2111
            .||.:|:  .|.|||:                  ||: :|:|...:|..:.||.|:|: |.||..
Human  1818 TRIRELE--FELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQ-VKVKSY 1879

  Fly  2112 SQQS 2115
            .:|:
Human  1880 KRQA 1883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	444/1814 (24%)
		MYSc_Myo18	575..1305	CDD:276837	200/766 (26%)
MYH3	NP_002461.2	Myosin_N	33..77	CDD:460670	4/21 (19%)
		MYSc_Myh3	100..767	CDD:276878	200/766 (26%)
		Actin-binding	656..678		7/33 (21%)
		Actin-binding	758..772		3/13 (23%)
		Myosin_tail_1	847..1924	CDD:460256	231/1059 (22%)