DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and MYH2

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_001093582.1 Gene:MYH2 / 4620 HGNCID:7572 Length:1941 Species:Homo sapiens


Alignment Length:2009 Identity:474/2009 - (23%)
Similarity:848/2009 - (42%) Gaps:504/2009 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   530 EENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKA 594
            |..|:::: ...|..|||.:|.|...|.|..|.:||:..:.:|:|.:||:.|::|||:.:|:|.:
Human    56 EGGKVTVK-TEGGATLTVKDDQVFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYS 119

  Fly   595 GPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSG 659
            |...:.|||...|.:|..:||:.:||.|.::.|||::|::..||:.::..|.:||::..|.||:|
Human   120 GLFCVTVNPYKWLPVYKPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAG 184

  Fly   660 KSTSFKHALNYLA------------LAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMT 712
            |:.:.|..:.|.|            :.:|.....:..:.::| ..:||||||.||..|.|::|..
Human   185 KTVNTKRVIQYFATIAVTGEKKKEEITSGKIQGTLEDQIISA-NPLLEAFGNAKTVRNDNSSRFG 248

  Fly   713 QLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSED 777
            :.:.:.|..||::|||.::..|.|:.|...:|..|.|:||..::.:.....|.:.|.:  .|:..
Human   249 KFIRIHFGTTGKLASADIETYLLEKSRVVFQLKAERSYHIFYQITSNKKPELIEMLLI--TTNPY 311

  Fly   778 SHPFISLSQ----KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGT 838
            .:||:|..:    .::|:    .:.|.|..|.:.|....:....|:.:..|:.|.|     .|..
Human   312 DYPFVSQGEISVASIDDQ----EELMATDSAIDILGFTNEEKVSIYKLTGAVMHYG-----NLKF 367

  Fly   839 GSTARTQFANP---TAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWE 900
            ....|.:.|.|   ..|.||:.|..:|..||..|   |..|....|....:|..|.    |....
Human   368 KQKQREEQAEPDGTEVADKAAYLQSLNSADLLKA---LCYPRVKVGNEYVTKGQTV----EQVSN 425

  Fly   901 CLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLR 961
            .:.||...:|.:....:||.||:|:.|.......|.::|..||:    |          :|..|.
Human   426 AVGALAKAVYEKMFLWMVARINQQLDTKQPRQYFIGVLDIAGFEIFDFN----------SLEQLC 480

  Fly   962 HNYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDLASECHPGPLISLIDKAPQNHVVRSS 1021
            .|:..|:||..|:|...|..::.|.:|     .::..||||: |     |.||:|.         
Human   481 INFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAA-C-----IELIEKP--------- 530

  Fly  1022 QRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAGPRQ--FVLHHLQ 1083
                     .|:..:|:||.::|.:.|.:|..:|: .|.|...:....:...|..:  |.|.|..
Human   531 ---------MGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAHFALIHYA 586

  Fly  1084 GTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLT-RGSGAMVFCGSFA---GL 1144
            |.  |.|.:.||:..::: |.....|.|.|.|:.:.:.:|:.|:.| .|.||    |..|   |.
Human   587 GV--VDYNITGWLEKNKD-PLNETVVGLYQKSAMKTLAQLFSGAQTAEGEGA----GGGAKKGGK 644

  Fly  1145 EGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYT 1209
            :...|.:.||::.|.                 .::.::..||.|..|||.|.:            
Human   645 KKGSSFQTVSALFRE-----------------NLNKLMTNLRSTHPHFVRCII------------ 680

  Fly  1210 ANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL----- 1269
                |:......:.|.|:|     ..|||.:.|||..|:.|.|||..:...:|.:|:.:|     
Human   681 ----PNETKTPGAMEHELV-----LHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAI 736

  Fly  1270 -AGDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRG 1333
             .|....:|..| |::||..::|...|:.|.:::.|::|:|..||..||..|:..|.:.||.|||
Human   737 PEGQFIDSKKAS-EKLLASIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQARCRG 800

  Fly  1334 YLAR---KKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEEL 1395
            :|||   ::|.:||.   |:.|||.|:::|:.|:.|||.:|..::.|||....||:::.|..||.
Human   801 FLARVEYQRMVERRE---AIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEF 862

  Fly  1396 LMLRAKLEKIECDRSE------------------VKAENQ-----------------KLEAKLSE 1425
            ..::.:|.|.|..|.|                  |:||.:                 :||||:.|
Human   863 QKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKE 927

  Fly  1426 LTVDLAEERSTAHIATERLEAE-TAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGI 1489
            :| :.||:.       |.:.|| ||::.|||.|..:....:.:|:.|..|:|.|....::.:..:
Human   928 VT-ERAEDE-------EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 984

  Fly  1490 SEDEDAENEDGVGGGVYKLKYERVA---------RELE--------FTKRRLHTQHEHD-----L 1532
            :|:     ..|:...:.||..|:.|         .:|:        .||.::..:.:.|     |
Human   985 TEE-----MAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL 1044

  Fly  1533 EQ-------LVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNL 1590
            ||       |...|:.||..|..|.|.:::......|...|.:|...|:::|:..:|::.|....
Human  1045 EQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQ 1109

  Fly  1591 LEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLAD----TRLDLEFKEEKL 1651
            |:||.::..|..:.|::.:..||.::.:..:::..|..|...:.:.|.:    |...:|..:::.
Human  1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE 1174

  Fly  1652 ASLQ---RELEEMTFG----------------GGTEEEFAQLRRSKNETERRAKEQEEELDEMAG 1697
            |..|   |:|||.|..                ....|:...|:|.|.:.|:...|.:.|:|::|.
Human  1175 AEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLAS 1239

  Fly  1698 QIQLLEQAKLRLE---MTLETMRKE--ARRESQQR-----------------------DE----- 1729
            .::.:.:||..||   .|||....|  ::.|.|||                       ||     
Human  1240 NVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALV 1304

  Fly  1730 ------------ELEEVRGNGYKKIKAL------------ECQL--------------------- 1749
                        ::||::....::|||.            :|.|                     
Human  1305 SQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSK 1369

  Fly  1750 ------------ETEHEERTLLLRE-KHELERRLSSMED---------------RDRVDRDAEE- 1785
                        ||:..:||..|.| |.:|.:||.:.|:               :.|:..:.|: 
Human  1370 ANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL 1434

  Fly  1786 ------------ALNQKLRR-------------------------------DLRKYKALLKDAQT 1807
                        ||::|.|.                               :|.|.|...:::..
Human  1435 MLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLD 1499

  Fly  1808 QLERLKADTPGKTLIRQLRNQLED-AESARSL--AMKARQTAEAELTEVQAMFDESHRARNDAEE 1869
            |||.||.:  .|.|.:::.:..|. ||..:.:  ..|.::..|.|..|:||..:|:..:....|.
Human  1500 QLETLKRE--NKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEG 1562

  Fly  1870 RANAAHRD----RAELQAQIEENEEELGELMKKYSATVKQLNT----------EQINV-SEAEFK 1919
            :......:    ::|:..:|.|.:||:.:|.:.:...|:.:.:          :.|.: .:.|..
Human  1563 KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGD 1627

  Fly  1920 LNEMEAERNNLKEQVAE------------------LQHRLDNVENLGDPSMAMMSKRLELRTKEL 1966
            |||||.:.|:.....||                  |...|.:.|:|.: .:||:.:|..|...|:
Human  1628 LNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKE-QLAMVERRANLLQAEI 1691

  Fly  1967 ES-RLELEQATRAR----------------LEVQVNRHKEALEKLQNEVT--QSKMREM--QAQD 2010
            |. |..|||..|:|                |..|........:||:.:::  |.:|.::  :|::
Human  1692 EELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARN 1756

  Fly  2011 VIKKSQKSLRD---MREEFHAVSSREQESLTRRKDLEKKVEQM---------ESEGAAL---KND 2060
            ..:|::|::.|   |.||.    .:||::....:.::|.:||.         |:|..||   |..
Human  1757 AEEKAKKAITDAAMMAEEL----KKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQ 1817

  Fly  2061 LRLALQRIADLQQAMEEEGE----------------EELS-ESDESLSSVGSISDLEDRL--RPV 2106
            ::....|:.:|:..:|.|.:                :||: :::|...::..:.||.|:|  :..
Human  1818 IQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVK 1882

  Fly  2107 HVKRSSQQSLNGSIGGGGGSVVSSTRTVVFEKDDNSPRITVTSPSSPHIHKLALAAKAI 2165
            ..||.::::...|     .:.::..|.:..|.::...|..:   :...::||.:.::.:
Human  1883 SYKRQAEEAEEQS-----NTNLAKFRKLQHELEEAEERADI---AESQVNKLRVKSREV 1933

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 213/801 (27%)
MYSc_Myo18 575..1305 CDD:276837 201/770 (26%)
GBP_C <1540..1750 CDD:303769 61/322 (19%)
COG1340 1565..1833 CDD:224259 83/441 (19%)
coiled coil 1723..1734 CDD:293879 7/50 (14%)
MYH2NP_001093582.1 Myosin_N 36..73 CDD:280832 5/17 (29%)
Myosin_head 88..772 CDD:278492 205/782 (26%)
MYSc_Myh2_mammals 100..772 CDD:276877 201/770 (26%)
Actin-binding. /evidence=ECO:0000250 661..683 8/37 (22%)
Actin-binding. /evidence=ECO:0000250 763..777 3/13 (23%)
Myosin_tail_1 852..1929 CDD:279860 223/1104 (20%)
RILP-like 967..1100 CDD:304877 28/137 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1128..1149 3/20 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1155..1174 3/18 (17%)
DUF342 <1672..1769 CDD:302792 23/97 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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