DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and Patj

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster

Alignment Length:	890	Identity:	154/890 - (17%)
Similarity:	277/890 - (31%)	Gaps:	314/890 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 PSGITADYSADFFAALNADANGGSNGGAVGAADPEQDRGNEEIVASVMTHIESRASNGAGVSVNY 138
            ||.:..|:..|....|....|||                      .||...:.:.|
  Fly    70 PSMLPNDFDIDVAGNLVLSLNGG----------------------EVMYDFDEQRS--------- 103

  Fly   139 SEVTHSLLSGGLKNRFLPPIPPKPPKRGILKGSRSNMTNVHEEISFAGSAGGAGGTPEMLLRNTF 203
            |..:||             .|..|.|                       :||.|..|    |...
  Fly   104 SSHSHS-------------APGSPDK-----------------------SGGVGEEP----RPQS 128

  Fly   204 QNESLYEGAARGAGSIGSNSSQHGTSFTSVESLRSDGEQTG------GQQRAMTLPANARYGALP 262
            ||       ::|||.    :..:.|.:..::::....:.||      |.:.:..:......|.:.
  Fly   129 QN-------SKGAGV----ADLYATDYAQIQAIELVNDGTGLGFGIIGARNSGVIVKTILPGGVA 182

  Fly   263 QGNSQ---GSH--------LHVLTSPSPSADSLTDTTN----------SSFATPPFSLSP----- 301
            ..:.:   |.|        ||.:.|...:|......|:          .|..||.::|.|
  Fly   183 DKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLRQSGTHVRLVVARPVEQSVPTPQYALEPGTAVV 247

  Fly   302 -----------------------VGESQGI---------DRWARVHAFEDVELPLPPV---QLVK 331
                                   .|||...         ||:  |:..|...|..|.:   :|:.
  Fly   248 PTRVLVDPAELERYLISTGYPEIFGESSTASTPQTTTEDDRF--VYRGETSMLIDPNIDLEELLA 310

  Fly   332 LPPPRQLVIRRQKSPRQDFGFSLRKAICLDRTESLTSPIFRPVIFAEPGAGGGATG-LLPGDRLI 395
            ||...:|.:..:|. ....|.::...:|  ..|.|:....:.|   .||:....:| :...||:|
  Fly   311 LPETEKLQVELKKD-ANGLGITIAGYVC--EKEELSGIFVKSV---SPGSAADLSGRIRVNDRII 369

  Fly   396 KVNGTPVGELPREIIIEMIRNSGEAVTVEVQ---------------------------------- 426
            :|:|..:........:|:::.||:.|.:.::
  Fly   370 EVDGQSLQGYSNHQAVELLKKSGQVVNLRLERYLRGPKFEQLQQAIAANDKLPSSAPGTPSRAPM 434

  Fly   427 --PVAELVELSKRCMAPSTATVEEIDH--------------SITNGNCNTLRRSASKRFKRQSRH 475
              |||   ..|.....||.:...|::.              |:|.....||
  Fly   435 PTPVA---TTSSATTTPSRSITRELEEEALPAPEAFMTTPPSVTTMTTTTL-------------- 482

  Fly   476 ENGNGGGE---------EGGAKGVGHDLEADVADASQPERVWLVHRGGFTAAIRLPTASSGRDEE 531
             :..|.|:         :|..|.:..:: ..:||.::.:...::.|..:...   |..|.  |.|
  Fly   483 -SSFGAGKQLVAVRDSLDGSTKIIPTEV-VPLADKTEAKNSGVITRHKYYTD---PELSD--DAE 540

  Fly   532 NKLSLRLLHN--GEQLTVDEDDVEKQNSPALDL-VEDICELKYLNEASVLHCLRQRYASNLIHT- 592
            .:: :|....  |..:.|....::|.....|.: :|...:::...|....|.:|.......:..
  Fly   541 TEI-IRKWQKIVGSDVEVIVAQIKKFAVGGLGISLEGTVDVEGGREVRPHHYIRSILPDGPVGVN 604

  Fly   593 ---KAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLI-FM 653
               ::|..||.||....|.:...:||::.:     ::|..|        |.:....|:.||: |.
  Fly   605 GVLRSGDELLEVNGERLLGMNHLEVVAILK-----ELPLDV--------RMVCGRNRNSSLLPFS 656

  Fly   654 GRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTI-LEAFGNTKTCLNSNATRMTQLLSL 717
            ..:....|.:|::.|       .|.:..:.|:...:|.|. ..|.|::   :.:.|...::|.|.
  Fly   657 DDTLKKLSNNFENLL-------PATDRLVKAKSDGSLATAGSVADGDS---VAAAAASFSKLKSR 711

  Fly   718 DFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMT---------------------------R 755
            ..:....:|..|.|..:.|..:..|.||    |.|:.                           |
  Fly   712 SLEPLTGLAMWSSQPQIIELVKGDRGLG----FSILDYQDPLDPNDTLIVIRSLVPGGVAQLDGR 772

  Fly   756 LLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMR 800
            |:.|...|....::|||         .||.|.::....|:...:|
  Fly   773 LIPGDRLLFVNSINLEN---------ASLDQAVQALKGASKGVVR 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	18/87 (21%)
		MYSc	556..1317	CDD:214580	53/279 (19%)
		MYSc_Myo18	575..1305	CDD:276837	50/259 (19%)
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
Patj	NP_477342.1	L27	12..70	CDD:295425	154/890 (17%)
		PDZ_signaling	154..226	CDD:238492	11/71 (15%)
		PDZ_signaling	318..400	CDD:238492	18/87 (21%)
		PDZ_signaling	557..643	CDD:238492	18/98 (18%)
		PDZ_signaling	726..807	CDD:238492	17/93 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900